Most of us have asked ourselves… how did we (or a loved one) wind up struggling with a neurological disorder like Parkinsons, ALS or Alzheimer’s?
While there’s no clear single cause identified, we do know that environmental toxins, genetics and even diet play a role in the risk.
Could Nutrition Help Prevent and Reduce Severity?
Researchers who’ve studied Parkinson’s and ALS agree that nutrient deficiencies play a role. Much like how a car won’t run without gasoline, the body needs certain nutrients (mostly from food) to operate properly.
Some research suggests that people with Parkinson’s disease (for example) often have certain nutrient deficiencies, including deficiencies in iron, vitamin B1, vitamin C, zinc, and vitamin D.
These nutrients are important for various functions of the body and brain.
Eat Healthy Food? It’s Not Always Enough.
What’s frustrating is that as we age, we absorb and produce far less of the enzymes, nutrients, minerals and vitamins we desperately need! That puts anyone who’s already at risk of disease, or battling one in a tough spot.
Taking a multivitamin that contains these nutrients may help improve some of the symptoms of Parkinson’s disease or prevent them from getting worse.
What’s So Great About Nutrients & Vitamins?
They all serve a specific purpose that helps prevent, support or improve a function in the body! Here’s some great examples of nutrients, and what they do:
Vitamin B1 helps convert glucose into energy for the brain cells.
N-Acetylcysteine is an amino acid that helps the body detox
Vitamin B12 helps the body make red blood cells
Vitamin B6 is used to maintain the health of nerves
Vitamin B7 helps support adrenal function and maintain a healthy nervous system
Magnesium Lactate is a mineral that supports the nervous and digestive system
Vitamin E protects your cells from oxidative damage
α-Lipoic Acid restores vitamin levels such as vitamin E and vitamin C
Phosphatidylserine plays an important role in keeping your mind and memory sharp
Glutathione is capable of reducing cellular damage
L-Carnitine helps brain function and muscle movement
We know that’s a LOT of information to take in, but it also gives a lot of hope!
Just boosting the levels of any number of these daily – in concentrated natural supplements could definitely help!
However, not all multivitamins are equal. Many low quality products on the market use synthetic or low quality ingredients. Some simply don’t provide you with enough of each nutrient or vitamin to see any real benefit.
The National Institute of Health has established a list of nutrients that are strongly recommended for people with neurodegenerative and motor neuron concerns such as ALS, Parkinson’s, PLS, PMA, Kennedy’s Disease, Dystonia, and many others.
Total Health AM & PM Powder Blends are based on the NIH’s standards. They contain 20 different nutrients that are vital for neurological and cellular health.
The AM & PM Blends work by providing your body with essential vitamins, minerals, antioxidants, amino acids, and other compounds that support your brain and nervous system function. They also help protect your cells from oxidative stress and inflammation that can cause damage and disease.
They are easy to use and mix well with any beverage. They even taste good and no artificial flavors or colors!
Ever heard someone say “I’m too old for that” or “I wish I could borrow that young person’s energy”? Most of us have just automatically assumed that getting older means feeling tired and exhausted.
The great thing is… Modern science would disagree!
Most of us experience more fatigue and less energy with age.
That’s because of genetic alterations in cells that cause muscles to lose mass and strength. As a result? Strenuous activities are just more tiring.
Even the heart muscles weaken, reducing the flow of oxygen-rich blood to the rest of the body. While even the fittest will not have the energy they had as a child, you certainly can dramatically reduce the decline as we age.
Here’s Some Ways to Boost Energy
Stay Active Exercise raises your heart rate. Over time, it helps strengthen your heart muscle so it can pump more with less effort.
For some, this one’s as easy as taking the dog for a walk, doing some gardening or time in a pool. Even some basic stretches, water aerobics or chair yoga can help.
Stimulate Muscle Growth Supplements like AKG help increase muscle strength and endurance by preventing Muscle protein breakdown. Vitamin D is also helpful for strong bones.
Boost Your Metabolism Vitamin B3 (Niacin) helps the body naturally burn more fat. It helps process proteins and activates stored energy instead of storing it.
Surprisingly, the other thing known to help the metabolism as we get older is sleep! One thing you’ll read in some of the testimonials of those who see symptom reduction is sleep quality. It’s just one of the side benefits of fewer symptoms.
“The memory of the feeling at that moment is still so vivid,” Sean recalls. “It felt as if the life completely drained out of my right arm from the elbow down.” A month later, he began to notice reduced dexterity in his right hand. Sean initially attributed these feelings to natural causes.
Eventually though, Sean saw a doctor and diagnosed him with Parkinson’s. “As laid in bed, I thought… How did this happen? What did I do wrong? What caused this?”
Parkinson’s diagnosis is often confirmed by the loss of dopamine-producing neurons within the substantia nigra portion of the brain. This is mostly due to age, genetic factors and environmental toxins that cause oxidative stress.
That stress causes damage to neurons within the brain.
Our glutathione levels tend to decline with age. Some of that is due to chronic inflammation, stress or diet… but there’s lots of possible reasons for it.
Ultimately, reduced glutathione leads to far more cellular damage.
It’s one of the causes of problems such as memory loss, mood disorders, and neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Fortunately, there are ways to increase your glutathione levels and support your brain health. One of them is taking glutathione supplements, which can provide a direct source of this antioxidant to your cells.
Studies have shown that easily absorbed glutathione supplements can improve cognitive function, reduce oxidative stress markers, and enhance mitochondrial function in older adults.
As the warmer weather and sunlight approaches the biggest travel season (next to Christmas) begins. Lots of older people and those struggling with neurological issues wonder, should I still travel?
You absolutely should!
Anyone who still has the ability to get out of a bed should do so as often as possible and enjoy this beautiful world. It might take a little extra planning, special accommodations for wheelchairs, elevators and pre-planning shorter duration activities, but quality of life depends on it!
#1. Get plenty of rest
Lack of quality sleep is tied to a long list of illnesses. In fact, it’s one of the early signs of diseases like Parkinson’s.
Our bodies naturally produce a hormone that helps provide a better nights rest. The problem is, people with a neurological disease usually don’t produce enough. Regularly getting extra Gamma-aminobutyric acid (GABA) is important as part of a healthy lifestyle.
After arrival at your planned destination, try to keep a similar morning, breakfast, lunch, dinner and bedtime as you do at home. Take your supplements, medications and foods around similar timeframes.
It seems obvious, but it’s easy to slip out of routine and face lower energy levels, stress or constipation. Those contribute to making trips memorable for all the wrong reasons.
One big benefit of sunlight is that it makes people happier. The body naturally produces more dopamine and Vitamin D while in the sunlight. Vitamin D helps the immune system, strengthens bones and even relieves pain! It’s even known to help sleep quality.
Low Vitamin D is also common for those with neurological conditions, which is why 83% of your daily intake is included in our Optimax Multi-Vitamin.
No matter where you go, who you visit or what sights you see… try to enjoy them to the fullest!
It’s those precious memories that make life worth living.
Why This Spice is Controversial Among Some Researchers
There’s a lot of argument these days about the key ingredient in curry. It’s what gives the dish its yellow colour and many studies have shown its potential to reduce inflammation, help the immune system, fight free radicals and help slow disease.
Uncontrolled Inflammation is a big problem as we get older. Most modern doctors believe that low-level inflammation actually plays a key role in the progression of metabolic, heart (1), Alzheimer’s, and neurological diseases.
Yet not everyone agrees the spice deserves all its praise.
While it’s been in use for thousands of years in India, China, Taiwan and Indonesia, much of the benefits claimed by health experts over the years have been hard to prove.
Some studies saw incredible results in a short period of time, and others saw fewer results. Curious why some didn’t see a difference right away? There’s a really good reason.
That’s because on its own, it doesn’t absorb well in the body.
It helps to consume it with black pepper (like BioPerine) a natural substance shown to enhance its absorption by 2,000% (2) and take enough to see a difference.
The other challenge is, while it’s commonly found in many foods, you’d have to eat a lot of them to see benefits (3). Still, a trusted old spice like Tumeric is safe and convenient, when taken as a supplement.
Turmeric is actually part of the ginger root family, and ginger is also known to have long-term anti-inflammatory benefits.
That’s why when our team of scientists, doctors and care-givers discussed making a better Tumeric based supplement, we included these:
Turmeric Root Extract – a highly concentrated version of the active ingredient Curcumin.
BioPerine – to help boost the absorption of Tumeric itself
Ginger Root Extract – to help protect the brain, gut and support healthy inflammatory levels.
Together they help give the best possible natural anti-inflammatory mix for potency, quality and absorption.
Modern sports teams, arthritis sufferers and many others take it regularly. They trust that it’ll help provide all natural relief without as many side effects as you might expect from non-natural or chemical alternatives.
Caring for someone who’s managing a neurological condition is a difficult road. Sometimes it can feel like you’re doing all the right things and still not seeing a change in their symptoms.
While everyone’s body, genetics and situation are different, we wanted to take a moment and cover some of the aspects of Neuro-Health Protocol.
Taking the protocol on a consistent schedule helps ensure a consistent supply of the amino acids, nutrients and minerals that help relieve symptoms. That’s why our system is broken up into a morning, afternoon and evening dosage plan.
The amount of each supplement needed is different for everyone. Some are only moderately deficient of the amino acids and nutrients and will need less. You can increase the dosage of AAKG daily by two grams per day every day to a maximum level of 18 grams.
It’s a good idea to encourage exercise to help stimulate and maintain the muscles. It’s not a good idea for those on the protocol to overdo it though… Even light resistance exercises and stretches are beneficial.
Some research shows a mediterranean diet can boost energy and help deal with symptoms of neuro-health disorders. The main thing is to avoid foods high in saturated fats, processed foods or those high in sugar. It’s also best to avoid large amounts of alcohol or foods that require a lot of chewing energy.
The National Institutes of Health (NIH) has put together a list of recommended nutritional supplements for Parkinson’s (and similar neuro-health diseases) for daily use. Most of these vitamins and minerals and in the appropriate dosages for healthy adults are available in Total Health AM.
While none of these are a cure, they’re often enough to help slow the progression and put you back in control.
The best thing we can do is increase the number of amazing memories and moments with our loved ones and increase quality of life.
Did you know an estimated 1 in 3 adults struggle with sleep? Studies show the average person is now getting two hours less than the previous generation did.
Lack of quality sleep is tied to a long list of illnesses. In fact, it’s one of the early signs of diseases like Parkinson’s.
While everyone’s different, there’s a few possible reasons why.
It could be that a reduced dopamine level can significantly impact the body’s natural sleep-wake cycle. For others, it can be impacted by sleep apnea, restless legs or frequent nighttime urination.
Our bodies naturally produce a hormone that helps calm the nervous system, relieve stress and help provide a better nights rest. The problem is, people diagnosed with a neurological disease usually don’t produce enough.
A lack of this hormone is also shown to be a contributing factor to headaches, heartburn, mood swings, digestive problems, high blood pressure and so much more.
Do We Have Anything More Precious Than Our Memories?
It’s a deep thought, but if you think about it, the precious memories of some of the most emotionally impactful moments of our lives are probably the most valuable thing we have in this life.
Being able to remember your wedding day, or even the first date. Recalling when your children were little, or those special christmases when they’re young and impressionable. If you lose almost everything else, those are what really matters.
If you’ve ever had the gift of spending time with someone who’s starting to see some memory loss, know how incredibly tough that can be.
One of the supplements on our website (Black Elderberry) is well known in the science community as an immunity helper, inflammation fighter and even an antioxidant. Some studies in a clinical trial showed that taking it shaved four days off the average FLU virus in people over 50, for example.(1)
BUT… Studies also show it helps improve memory function!
Some with ALS, Parkinson’s and other neurological disorders often demonstrate symptoms similar to Alzheimer’s, dementia and other memory loss disorders later in life.
The cause of these neurological disorders is unknown but, one thing we do know is they’re all caused by the amyloid plaques that collect between neurons and disrupt cell function. (2)
Could This “Flu Fighter” Help?
What’s exciting is that Black Elderberry was tested in animals with amyloid plaque build up, and their memory improved despite having Alzheimer-like symptoms. (3)
That study is fairly recent (2022) but… we know that the flavonoids in elderberries and elderflowers include quercetin, and are recognized for their ability to protect cells.
So, whether you’re looking for something that helps boost the immune system or something that could help with cognitive function and support the brain naturally, Black Elderberry is a great option.
In the 17th century, Captains sailed from port to port trying to outrun Scurvy. The British Navy alone lost 133,000 sailors to it. It wasn’t until the 1960’s when clinical trials clearly demonstrated it was curable by access to fresh fruit or Vitamin C.
Modern antibiotics were available in ancient Egypt, but modern doctors didn’t discover and administer them until the 1950’s.
When you consider how fast scientific research is funded, conducted and released to the public, these supplements are a very recent discovery.
The unfortunate thing is… not every substance and application that deserves testing and study is actually funded each year.
The big question is… Should you trust that AKG could actually help?
Our bodies already produce high levels of Alpha-Ketoglutarate (AKG)… but after age 40, levels of AKG drop dramatically. Everyone’s body needs it, but it would be unrealistic to eat enough of the foods that could replace it.
AKG is responsible for at least 600 enzymatic reactions in our body. For instance, AKG is the primary enzyme group we use to make glutathione for our red blood cells.
New studies proving its benefits are released all the time.
Here’s just some of them:
Alpha-ketoglutarate increases life span, reduces frailty and reduces inflammation in middle-aged mice (1)
AKG has been shown to have a protective effect against osteoporosis (2)
Dietary AKG may improve protein metabolism and synthesis in older adults (3)
When combined with Vitamin B, AKG may be essential in long-term nerve strength, memory, and neurotransmission (4,5)
In mice, AKG inhibited liver disease progression (5)
AKG has been shown to improve kidney function in patients with chronic renal failure (5)
Topical AKG reduces skin wrinkle formation by increasing collagen production (6)
AKG prevents skeletal muscle degradation and muscle atrophy (7)
AKG can prevent the brain from oxidative damage by increasing neuronal concentrations of antioxidative enzymes (8)
There’s no doubt that Alpha-Ketoglutarate has a lot of potential benefits… but the real question is…
Does it matter where you buy it?
We think it does. You don’t always know where or how some brands source their ingredients. We’ve fought hard to find the most pure, easily absorbed and naturally sourced ingredients produced right here in the USA.
Potency is important. That’s why you may not need as much of our AKG supplement as other brands.
You’ll also notice our AAKG+ Core Blend includes Vitamin B (niacin) which helps nerve strength as mentioned above. It also includes an easily absorbed CoQ10 supplement for brain & muscle health.
If you or someone you love has been diagnosed with a brain, neurological or age-related condition, it’s worth trying a month’s supply (one container with 90 servings).
Most of us produce less Glutathione as we age. Studies show those with neurodegenerative diseases like Parkinson’s produce even less than the average person.
It’s one of the most effective antioxidants available.
Our cells naturally produce free radicals as part of their metabolic process, but that’s amplified when exposed to toxins like x-rays, cigarette smoke, and other pollutants.
Free radicals are the largest source of electron damage in nerve cells.
Here’s an interesting number… A healthy body creates over 32 sextillion free radicals per day! When we age, our bodies slow down the creation of enzymes that break down free radicals.
This daily build up of free radicals is one of several factors that lead to the neuron damage thought to play an important role in the progression of Parkinsons. (1)
Glutathione is one of the main antioxidants that slow down the process of cellular damage, although most won’t see benefit in taking it orally. That’s because the acid in our stomach would destroy most of it.
It’s Baffled Many Scientists… Some Clues Show Why These Folks Live So Long
It’s no secret that some places have lower rates of Parkinson’s, ALS, heart disease or any other illnesses we commonly associate with old age. The amazing thing is, one such place is the island of Ikaria in Greece.
It’s a place where 2.5 times as many people live past the age of 90 (compared to the USA). Not only do the people of Ikaria live longer, they also live higher quality lives with fewer incidences of dementia or other neurological disease.
According to a study conducted by the Medical School of the University of Athens, Icarians live at least until their 90th year of age.
Cardiology Research and Study
You might think it’s the simple low-stress lifestyle that helps them live so long, but most of it has to do with regular exercise and diet.
Here’s some lessons we can learn from the Ikarian people:
Lower intake of saturated fat from meats or dairy
Regular use of olive oil which helps lower cholesterol
Eating wild greens and other antioxidants
A mediterranean diet with plenty of fish, vegetables and fruit
An afternoon nap which has been shown to decrease stress
What’s interesting is… L-arginine – The amino acid found in food that is what allows the body to produce AKG naturally – is found in most of the foods of Ikaria!
Foods like fish, chicken, beans, whole grains, nuts and seeds are all good sources of L-arginine. The sad thing is, we produce less AKG from these foods as we age.
Countless studies have shown that AKG can help reduce symptoms associated with neurological diseases such as muscle spasms, but did you know it can also support healthy ageing?
It’s been used to speed up wound healing times, protection for patients undergoing heart surgery and increase natural energy levels in athletes.
Years ago, we discovered some of the supplements offering the same ingredient lacked the potency needed. We also felt there were a few other elements that would support neurological health as we age and support those struggling with some diseases.
We can’t all move to Greece, but we can definitely take some dietary, supplement and lifestyle changes to help live a better quality of life.
If you’ve ever known anyone with ALS, it’s heart-breaking to watch.
One day they’re walking, cooking, doing yard work, and living a normal life.
Next day, you watch as they keep tripping over the edge of the carpet…
…can hardly make it through a meal without coughing……and their fingers refuse to close around a mug handle for a simple sip of coffee.
Every 90 Minutes Someone Gets the News…
Some catch it early.
Most, like Paul, catch it in their 60s.
“My wrist hurts when I twirl it around. I get tremors. Body twitching.”
“What bothers me the most is my face. My tongue won’t cooperate anymore. And my words are so slurred, my wife can’t understand me half the time. It’s insanely frustrating!”
And he knows it will only get worse.
His family dreaded the day in the future when Paul would likely not be able to walk or even breathe.
152 years after its discovery, ALS continues to strike without warning . Every year, ALS turns the lives of 6,000 Americans into a living nightmare. 
It’s Like the Body Stops Listening To the Brain’s Command
While scientists can’t yet pinpoint why some people get ALS, they know the downward spiral is caused by nerve damage…
Damage that chips away at the lining of a special type of nerve; motor neurons.
Think of motor neurons like the wiring that connects lights in your living room to a switch. Normally, you flip the switch, and all the lights go on.
The problem is… once ALS shows up on the scene, these wires start to erode and deteriorate.
One day you walk into your living room and flip the switch, expecting brightness.
This time, only half the lights illuminate.
The other light bulbs are still there.
But they remain dark. Those wires failed.
They never heard the command to turn on.
A similar thing happens to the motor neurons connecting the brain to the spinal cord of an ALS patient.
It’s a tidal wave that forces more neurons off the grid. They lose their ability to talk to muscles in the arms, legs, chest, throat and mouth.
It’s like the brain keeps talking in a language the muscles can no longer understand.
If you or your loved one has ALS, this is when they need help dressing and showering.
Others may notice one arm losing strength.
The sad truth is… 4 out of 5 people with ALS are likely to suffer asymmetric limb weakness. 
One side of the body works. The other side grows frail and atrophies.And while scientists have yet to figure a clear-cut treatment…
Here’s a Ray of Sunshine in a Dark Sky
In this special report, I’m going to show you a breakthrough protocol… that uses nutrients found naturally in the body… to help 7 out of every 10 people who try it. 
That’s not all…
…while you’d expect everybody to respond differently, more than half the people who follow this methodology report elevated energy levels and…73% report a reduction in muscle tremors. 
What makes this protocol work is, it takes a different approach:
Instead of focusing on the symptoms, it helps brain nerves survive the ALS toxic tsunami wave.
What’s the toxic tsunami wave?
Well, scientists have long known this is one of the first red flags that… flips the environment of surrounding brain nerves to go from livable to a living hell.
Case in point, it only takes 24 hours for this destructive cocktail to start deteriorating brain neurons. 
And this is important because, the deterioration (and death) of these neurons is the reason why ALS patients start feeling their muscles weaken and ultimately become paralyzed.
What Spanish Scientists Discovered While Saving Neurons of Stroke Survivors That May Help Those With ALS
A few years ago, a team of Spanish scientists set out to figure the best way to save the most brain nerves after someone had a stroke. 
This is especially challenging because, the worst hit area (the core zone) suffers an extreme drop in blood flow. As you’d expect, this leaves brain nerves without oxygen and glucose.
In short, leaving brain nerves with no way to produce energy.
The longer this goes on, the more brain neurons perish.
No energy, no life. Remember that.
The Spanish scientists witnessed another phenomenon that accelerates the death of neurons.
In a healthy brain, glutamate is a friend. This essential amino acid helps neurons talk to each other. It also helps us with memory and learning.
When someone suffers a stroke, glutamate is a foe. It’s bad news because glutamate levels in the brain spike to 10 times normal levels, contributing to the deterioration of the brain… 
Triggering a Toxic Tsunami That Kills Brain Neurons
The rising glutamate is like an accelerating tidal wave:
Glutamate shoots up to levels the body can’t handle.
As you already know, this pushes motor neurons to deteriorate and die.
As these cells die, they burst, releasing more glutamate into the system.
This in turn, elevates glutamate levels even higher, affecting more neighboring cells.
You can probably guess what happens to those neighboring cells? They too die and burst, releasing more glutamate.
And so on and so on until the body is flooded with toxic levels of glutamate. It’s a vicious downward spiral.
When there is a flood of glutamate in our brains, it’s almost as if the wiring stops connecting with the rest of the body, like in our light switch example.
Just like with stroke victims, we believe the same phenomenon of unplugging the brain communicator cells from the rest of the body is at play when it comes to ALS.
So What Can You Do About It?
Many people suffer needlessly because they don’t know their options.
For example, you might think that the most effective approach is pressing the brakes on that glutamate ‘toxic tsunami.’
Afterall, that’s the approach used by one of the more popular solutions for ALS .
What kind of relief does it offer?
Only a median increased survival time of about two to three months.
What’s more, England’s National Health Service reports that patients who use it… ‘feel no different day-to-day.’ 
And while we always recommend consulting your physician on what would help you the most, we suspect you’re here for a reason…
…you want to leave no stone unturned because:
While we don’t know how many tomorrows we’ll have…
We Can’t Sit and Watch as Our Loved Ones Fade Away
That’s why, back in 2014, we decided to take a different approach to helping ALS patients live a better life.
Remember how the Spanish scientists discovered one reason that triggers neurons to perish is… they are left with no way to produce energy?
No energy. No life.
So, what’s the battery that energizes our cells?
It’s the mitochondria. When you build up the strength of this powerhouse, it can withstand the onslaught of glutamate.
So, instead of trying to stop the glutamate ‘toxic tsunami’ wave by changing the cell’s environment (as other popular solutions do), we’re arming neurons to survive that brutal toxic wave war.
The result is Simplesa’s AAKG+ core protocol blend.
AAKG+ is an advanced, four-in-one nutritional solution that’s purposely designed to help alter the course of ALS.
And it does this by fueling the cellular energy cycle. This, in turn, kicks the mitochondria’s ‘energy production capacity’ into high gear.
New energy. New life.
With consistent use, Simplesa’s AAKG+ helps ease muscle twitching, relieve body weakness and support elevated energy levels.
And while everyone responds differently, it’s not uncommon to hear comments like this one from Jennifer:
“It gives me the energy to stay up all day, like from 7 am to midnight.”
In a moment, you’ll get to hear 100 more reviews to help you decide if AAKG+ is right for you or your loved one.
First, let’s cover the 4 potent ingredients that make AAKG+ work.
The 4 neuro-nutrients are meticulously sourced and scientifically formulated right here in the USA… to ensure the highest absorption rates and uncompromising quality.
It starts with…
#1) The Key to Replenishing Our Cellular Battery
Alpha-Ketoglutarate (AKG) is a natural substance that’s concentrated in the cell’s mitochondria (the battery that energizes our cells) and the liquid gel which fills our cells.
AKG isn’t just a potent antioxidant, that also increases collagen production , it also plays a much bigger role:
It regulates the speed of cellular energy production.
Case in point, draining the levels of AKG in our cells is like pressing the breaks on the cell’s ability to produce energy.
And this happens because AKG works as an ‘energy donor’ in the Krebs cycle.
You may remember the Krebs cycle from science or biology class. Without getting too technical, the Krebs cycle is an 8-step chain reaction happening inside our mitochondria.
End result? Energy that powers all living cells.
Here’s where it gets interesting…
Scientists have long known that the cell’s energy production rate is linked to how fast we age. The lower our cellular energy is, the faster we age. 
So, researchers at the Buck Institute wanted to figure the impact of consuming AKG. [12, 13]
Could it put the usual signs of cell aging on time-out?
In the study, researchers divided 182 aging mice (55 years in human years) into two groups. Only one group of mice was fed a diet containing AKG.
Then, every 8 weeks the researchers would measure for signs of vitality and zest for life (such as eye health, tremors, grip strength, and curving of the spine among other signs of aging). This went on for 21 months, or for as long as mice were alive.
The result: the group that consumed AKG saw a 40% boost in healthspan.
It’s not merely surviving as the years go by. It’s enjoying blissful days, free of the usual alignments and disabilities that come with age.
Walking, breathing, living and having a zest for life.
For those reasons, AKG is the key superstar ingredient we’ve included in Simplesa’s AAKG+.
It also includes…
#2) COQ10 to Shield Against Neuron Damage
You may have heard of CoQ10 and how it’s among nature’s most powerful antioxidants.
But did you know it’s more effective than vitamin E when it comes to protecting against cell neuron damage. 
And, neuron damage is one of the main reasons the brain communicator cells lose their ability to talk to the rest of the body.
In fact, studies show that CoQ10 might play a bigger role than we once thought when it comes to… helping turn around nerve damage (like ALS).  
But that’s only part of the CoQ10 story.
It’s no coincidence that CoQ10 lives in the cell’s mitochondria (our energy powerhouse).
You see, CoQ10 isn’t just essential for helping the body patch up repair damaged cells, it’s also the spark your cells need to generate energy.
Just like AKG, it plays a crucial role in amplifying the cell’s energy production rate (the Krebs cycle).
Are you starting to see how CoQ10 plays two critical roles when it comes to ALS?
On one level, it helps protect the mitochondria from damage (the potent antioxidant effect).
While, at the same time, it boosts the mitochondria’s ability to produce energy. Energy it needs to survive the glutamate ‘toxic tsunami.’
For those reasons, we’ve included the most bioavailable form of CoQ10 in Simplesa’s AAKG+. But that’s not all, AAKG+ has one more ingredient that…
#3) Helps Squash The Toxic Tidal Wave
GABA (Gamma Aminobutyric Acid) is a chemical messenger in the brain. It has a calming effect.
Our body needs this to make it through stress and anxiety – without crushing our nervous system.
Simply put, it shields our nerve cells from being over-stimulated (stressed out).
Why is this important when it comes to ALS?
In healthy adults there’s a balance between GABA and glutamate.
The first calms our nerves, the second excites them. It’s like an on and off switch.
But what happens if the switch is always on?
Like a morning alarm clock that buzzes forever. No rest.
We suspect that’s what’s happening to the brain cells of someone with ALS. In fact, studies show that GABA levels diminish and dip as glutamate levels spike. 
Sounds familiar? This is the glutamate ‘toxic tsunami’ wave pushing neurons to the edge of existence.
There’s two more reasons for including GABA in AAKG+.
Firstly, we want to replenish the body’s GABA stores – because low levels of GABA contribute to muscle spasticity and stiffness.
And, secondly, GABA pushes back on the excessive glutamate levels… giving neurons a fighting chance against the toxic tidal wave.
Knowing that, we did extensive research to identify the most effective approach to…
#4) Help Brain Neurons Survive and Regrow
Niacin is a water-soluble B vitamin. Once in the body, it’s converted into the second most important coenzyme in the body; NAD (nicotinamide adenine dinucleotide).
Why is it so important?
Because it’s one of only a few coenzymes that directly impact the body’s ability to create and utilize energy.
In fact, supplementing with NAD has been shown to bump up the mitochondria’s ‘energy production capacity.’ 
What’s more, mental agility is often a sign of sufficient NAD levels in nerve cells. Why? Because it plays a key role in brain neuron development and survival.
Naturally, scientists wanted to put this to the test in the most extreme of conditions; stroke survivors.
You see, one of reasons a stroke (or spinal cord injury) cripples the person’s ability to move, or even feel their limbs is… the cell’s inability to regrow axons. 
What are axons? Simply put, it’s the thin ‘wire like’ structure of the neuron that helps it communicate with other neurons.
So, here’s what scientists at Oakland University did:
They simulated a stroke in lab rats by blocking blood flow to the brain for two hours. Then, they separated the rats into two groups. One group was fed a daily dose of niacin for 14 days. 
Scientists were amazed by the results: niacin plays a major role in supporting the nerve’s regeneration process (neurite outgrowth).
Can you see how this is relevant to ALS?
Case in point, scientists believe this nerve regeneration (neurite outgrowth) process is a critical factor in restoring neuron function after it’s damaged. 
By now, you can probably see why we’ve included Alpha-Ketoglutarate (AKG), GABA, Ubiquinol (CoQ10) and Niacin in Simplesa’s AAKG+ Core Powder.The 4 neuro-nutrients in AAKG+ aren’t just 100% natural, they’re also…
The Purest Form, Potent Compounds to Ensure the Highest Bioavailability and Purity
What this means is… we’ve gone to extreme lengths to source these 4 neuro-nutrients are in the purest, freshest and most effective form.
The same raw form supported by scientific research. (You can see the certificates of analysis right here.)
No fillers. No cutting corners because our client’s wellbeing depends on it.
It’s been our pledge since starting back in 2014; quality first.
That’s why, Simplesa’s AAKG+ is scientifically formulated and manufactured in the USA in an FDA inspected facility.
What’s more, the 4 neuro-nutrients in AAKG+ aren’t just designed to work in synergy… where the combined effect is far greater than taking each nutrient on its own… Simplesa’s AAKG+ is purposely designed to…
Soothe away muscle discomfort and weakness. Instead of watching muscles waste away this helps your body get stronger.
Increase mitochondrial energy output to help give you the energy you need to live life.
Reduce anxious feelings and negative moods (start feeling like your normal self again).
Sooth away muscle fatigue, leg cramps and muscle twitching that makes holding a cup of coffee near impossible.
The most bioavailable form of CoQ10 (Ubiquinol) helps give further protection against cell neuron damage.
Thousands of men and women swear it helps slow down progression and improve their quality of life. And now, you can too.
How Much of a Difference Can AAKG+ Make?
Just ask Scot , Sarah, Ronnie and others…
And while I can’t promise a magic carpet ride (because everybody’s different), here’s how it’s been changing lives since 2014:
If you’ve read this far, I think you can see why…
You Too Can Benefit From AAKG+
We also made sure it’s not another stack of ‘hard to swallow’ pills.
Instead. it’s super simple to use:
Simply add 1 leveled scoop to any beverage or food with a consistency that permits easy mixing.
Stir until thoroughly mixed. (It tastes good and mixes well and easily with a shaker bottle.)
Take three times daily or as directed by your health care practitioner.
As you’d expect, Simplesa’s AAKG+ has clearly spelled out ingredients (no mystery blend that leaves you wondering what’s in the mix):
Now, it’s perfectly normal to realize that… the only way to help you decide if AAKG+ is right for you or your loved one, is getting it into your hands (so you can start using it and noticing the difference it makes).
For that reason, we’ve done 3 things:
Firstly, you pay zero for shipping and handling.
Since AAKG+ isn’t available in health food stores, we’re eating the cost of shipping to get it into your hands as soon as possible (and let it start working for you or your loved one right away).
Secondly, you risk nothing by trying AAKG+ today.
All we ask is that you use it for 30 days. If, at any point in the next 90 days, you’re not satisfied with for any reason (or no reason at all), then return the empty bottles for a full, courteous refund.
Thirdly, because the results have been so positive, we’re trying to get it into the hands of more people who need relief now.
That’s why, for a limited time, you can take advantage of this exclusive offer…
Try AAKG+ Risk-Free at the Lowest Price and Get a Free Gift
If you tried to purchase just 2 of the 4 neuro-nutrients in AAKG+ at your local health food store… getting a 30-day supply of CoQ10 (Ubiquinol) and high-dose AKG… you could easily spend up to $318.5.
And you’d have no guarantee you’d get these neuro-nutrients in the most effective pure form compounds to ensure the highest bioavailability.
But thanks to this special offer, you can get all 4 neuro-nutrients in one convenient, easy to use solution (instead of having to mix and match what might be ‘hard to swallow’ pills)… for as little as $4.99 per day.
That could save you as much as $168.51 per month.
Here’s the best part, if you decide to go for the 60-day supply today…
You’ll Get 2 Free AAKG Powder Tubs (Worth $51.98)
Here’s why this is the perfect companion to Simplesa’s AAKG+…
As you already know, we’ve included Arginine Alpha-Ketoglutarate (AAKG), GABA, Ubiquinol (CoQ10) and Niacin in Simplesa’s AAKG+ Core Powder.
3 of the neuro-nutrients (GABA, CoQ10 and Niacin) are in full dosages. The fourth neuro-nutrients (AAKG) is set at the minimum recommended dosage of 9 grams a day.
Why is that important?
To allow you to increase your increase AAKG dosage up to the recommended 18 grams per day at your own pace (without having to increase GABA, CoQ10 and Niacin at the same time).
That’s where Simplesa’s AAKG Powder comes in.
It’s the same high-potency, pure form amino acid in AAKG+
Simplesa’s protocol calls for 3 main servings of AAKG+ per day and…
Smaller doses of AAKG throughout the day.
This is intended to support energy production through the day
Normally, you’d have to buy AAKG separately. However, on this page only… you get two complementary AAKG tubs with your 60-day supply. Take advantage of this generous offer today because it won’t be available forever.
Choose Your Package
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.
 Deanna Protocol Program for ALS: Substantiation and Putative Mechanisms. 2016.
 “ALS Incidence and Prevalence Worldwide.” Alstreatment.com, alstreatment.com/amyotrophic-lateral-sclerosis-incidence/.
 “Unmet Needs: A Brief History of ALS and Its Sparse Pipeline.” Pharmaceutical Technology, 10 Sept. 2021, www.pharmaceutical-technology.com/analysis/history-of-als/.
 Morris, Tom. “Dr. Richard Bedlack’s Quest for ALS Discovery: The Truth Is out There.” ALS Society of Canada, 27 July 2017, als.ca/blogs/dr-richard-bedlacks-quest-als-discovery-truth/. Accessed 3 Jan. 2023.
 Castillo, José, et al. “A Novel Mechanism of Neuroprotection: Blood Glutamate Grabber.” Journal of Cerebral Blood Flow & Metabolism, vol. 36, no. 2, 2 Oct. 2015, pp. 292–301, 10.1177/0271678×15606721. Accessed 2 Dec. 2022.
 “A Novel Mechanism of Neuroprotection: Blood Glutamate Grabber.” Journal of Cerebral Blood Flow & Metabolism, vol. 36, no. 2, 2 Oct. 2015, pp. 292–301, 10.1177/0271678×15606721. Accessed 2 Dec. 2022.
 “Should I Take Riluzole? – Oxford MND Centre.” Www.ouh.nhs.uk, www.ouh.nhs.uk/services/departments/neurosciences/neurology/mnd/support/riluzole.aspx.
 Asadi Shahmirzadi, Azar, et al. “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.” Cell Metabolism, vol. 32, no. 3, Sept. 2020, pp. 447-456.e6, www.ncbi.nlm.nih.gov/pmc/articles/PMC8508957/, 10.1016/j.cmet.2020.08.004. Accessed 3 Jan. 2023.
 “Should I Take Riluzole? – Oxford MND Centre.” Www.ouh.nhs.uk, www.ouh.nhs.uk/services/departments/neurosciences/neurology/mnd/support/riluzole.aspx.
 Son, Eui Dong, et al. “Alpha-Ketoglutarate Stimulates Procollagen Production in Cultured Human Dermal Fibroblasts, and Decreases UVB-Induced Wrinkle Formation Following Topical Application on the Dorsal Skin of Hairless Mice.” Biological and Pharmaceutical Bulletin, vol. 30, no. 8, 2007, pp. 1395–1399, 10.1248/bpb.30.1395. Accessed 1 Oct. 2021.
 “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.” Cell Metabolism, vol. 32, no. 3, Sept. 2020, pp. 447-456.e6, www.ncbi.nlm.nih.gov/pmc/articles/PMC8508957/, 10.1016/j.cmet.2020.08.004.
 “Buck Institute Study: Bodybuilding Supplement Might Boost Health.” The Mercury News, 7 Sept. 2020, www.mercurynews.com/2020/09/07/buck-institute-study-bodybuilding-supplement-might-boost-health/. Accessed 3 Jan. 2023.
 Matthews, R. T., et al. “Coenzyme Q10 Administration Increases Brain Mitochondrial Concentrations and Exerts Neuroprotective Effects.” Proceedings of the National Academy of Sciences, vol. 95, no. 15, 21 July 1998, pp. 8892–8897, 10.1073/pnas.95.15.8892. Accessed 25 Aug. 2021.
 Shults, Clifford W., et al. “A Possible Role of Coenzyme Q10in the Etiology and Treatment of Parkinson’s Disease.” BioFactors, vol. 9, no. 2-4, 1999, pp. 267–272, 10.1002/biof.5520090223. Accessed 3 Jan. 2023.
 “A Possible Role of Coenzyme Q10in the Etiology and Treatment of Parkinson’s Disease.” BioFactors, vol. 9, no. 2-4, 1999, pp. 267–272, 10.1002/biof.5520090223. Accessed 3 Jan. 2023.
 “Brain Imaging Suggests Neurotransmitter Imbalance in ALS | ALZFORUM.” Www.alzforum.org, www.alzforum.org/news/research-news/brain-imaging-suggests-neurotransmitter-imbalance-als. Accessed 3 Jan. 2023.
 Jia, Haiqun, et al. “High Doses of Nicotinamide Prevent Oxidative Mitochondrial Dysfunction in a Cellular Model and Improve Motor Deficit in a Drosophila Model of Parkinson’s Disease.” Journal of Neuroscience Research, vol. 86, no. 9, 1 July 2008, pp. 2083–2090, pubmed.ncbi.nlm.nih.gov/18381761/, 10.1002/jnr.21650. Accessed 3 Jan. 2023.
 Sun, Nuo, et al. “The Mitochondrial Basis of Aging.” Molecular Cell, vol. 61, no. 5, Mar. 2016, pp. 654–666, 10.1016/j.molcel.2016.01.028.
 Cui, Xu, et al. “Niacin Treatment of Stroke Increases Synaptic Plasticity and Axon Growth in Rats.” Stroke, vol. 41, no. 9, Sept. 2010, pp. 2044–2049, 10.1161/strokeaha.110.589333. Accessed 21 May 2022.
 Walmsley AR, Mir AK. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. Curr Pharm Des. 2007; 13: 2470–2484.CrossrefMedlineGoogle Scholar
This year alone, 50,000 Americans will be diagnosed with Parkinson’s disease (PD). The number of cases in the US suffering with PD will be close to 1.0 million patients by 2020. This neurological disorder is second in total number of patients only to Alzheimer’s disease. What’s concerning our physicians the most is that the number of cases seems to be increasing. A report from the Mayo Clinic in March 2019, showed that the incidence of PD has increased significantly in the 30 years between 1976 to 2005 (1).
Neurologists serve in the front lines of the fight against PD, ALS (Amyotrophic Lateral Sclerosis) and Alzheimer’s. Their work load is increasing and sadly, the number of qualified neurologists available to take care of us is not keeping up with the increasing number of cases of these diseases.
The reality of Parkinson’s disease is upon us and the trend tells the full story. We can do nothing… or we can begin to take action now. If you fall into the latter group (and we hope that you do) we’ve got some good news.
Patient education and self-help efforts are increasing. New treatments and local support groups are emerging that help disseminate valuable information to help fight PD. Taking responsibility for your health is THE smartest strategy. Expecting that our health care system will be there for us and take care of us during a chronic disease is not a bet one should take. Take responsibility for your PD.
In the event that you’ve been diagnosed or are currently suffering with PD, what do you do now? Here’re some therapies and co-therapies that will help you fight PD.
Make sure that you’re being treated by your Doctor or Neurologist
Step one is to make sure that you get yourself the best professional care you can get. You can find a neurologist near you on WebMD.
L-dopa (Levodopa) Supplementation for PD
This is the go to drug for PD. It helps increase dopamine levels that cause many of the symptoms associated with PD. Although it’s not a cure, it helps keep symptoms under control during the early stages. Remember that L-dopa cannot reduce every PD symptom. Talk to your physician about this therapy.
Nutritional Supplements for Parkinson’s Disease
The Parkinson’s Foundation lists certain Nutritional Supplements, such as anti-oxidants and vitamins, as possible Over the Counter (OTC) and Complementary Therapies (4). These nutritional supplements for Parkinson’s disease show improvements in the reduction of certain symptoms of the disease. Among the more promising natural remedies for PD are:
Coenzyme Q10 (CoQ10): also known as Ubiquinone, seems to play an important role in Mitochondrial health, the power center of our cells. A more concentrated form of Ubiquinone is Ubiquinol. This powerful neural booster is present in the AAKG+ product from Simplesa Nutrition. This supplement is most helpful in reducing tremors and muscle rigidity.
Vitamins E and C: can fight damage in the brain and neurons caused by free radicals and may even lower the risk of getting PD in the first place. These vitamins are most helpful in reducing damage to your neurons.
Glutathione: is known as one of the most powerful antioxidants available. A better absorbing form of Glutathione is called Liposomal Glutathione. Few supplements have received the level of positive comments from the scientific community that Glutathione has received. This supplement is most helpful in reducing oxidative damage to your organs and nervous system.
Vitamin B-12: also known as Methylcobalamine is an important vitamin in nerve and brain health and may have a significant effect in protecting our memory. Vegetarians often have an acute Vitamin B-12 deficiency. Look for sublingual Liposomal B-12 for best absorption. This supplement is most helpful in helping your higher brain functions and in protecting your memory.
Multi-Vitamin supplements: The National Institutes of Health (NIH) has put together a list of recommended nutritional supplements for Parkinson’s for daily use. Most of these vitamins and minerals and in the appropriate dosages for healthy adults are available in Total Health AM. This multi-vitamin and multi-mineral is most helpful in providing the necessary building blocks for a healthy body to help fight disease and repair damage.
Diet and Exercise
We know we keep hearing about it but Diet (Mediterranean Diet) and Exercise keeps the body healthy, your immune system robust and your renal and endocrine (detoxing) systems humming along. Stay with this winning strategy!
Embrace a Spiritual Life
If you’re religious, great! If you’re more of a free spirit, that’s ok too. At the very least spend time on the inside. Meditate, pray, breathe deeply, be mindful and be thankful. These simple co-therapies will help you cope with your PD and with the everyday challenges of life. As someone once said, “Life is not measured by the number of breaths we take, but by the moments that take our breath away…”.
So there you have it. PD will probably change your life but it’s not necessarily a death sentence. If you take responsibility for your PD, the progression will be slower, you will be in control, live a quality life and you will most likely increase the number of moments… that take your breath away.
Source: 1. Thelen, Gil. “A Parkinson’s ‘pandemic’ is coming and there aren’t enough doctors to deal with it.”, THE MIAMI HERALD, March 25th, 2019. 2. Parkinson’s Foundation, “New Study Shows 1.2 Million People in the United States Estimated to be Living with Parkinson’s Disease by 2030”, PARKINSON.ORG, July 10th 2018. 3. Mayo Clinic. “Parkinson’s disease”, MAYOCLINIC.ORG. 4. Parkinson’s Foundation, “Over the Counter and Complementary Therapies”, PARKINSON.ORG
*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
Finding a cure for ALS continues to be a difficult and elusive endeavor. This is understandable since the body is a complex system. Moreover, the degree of difficulty of finding a cure goes up exponentially, when one talks about the body’s nervous system. Nevertheless, advances and findings are coming to light rather quickly and we may be one piece of the puzzle away from a major breakthrough.
One cannot help but notice that within these new findings, certain similar themes that trigger ALS keep coming up. One such theme is the damage caused by the increase in energy expenditure by the nerve cells. A recent study called “Consideration of gravity as a possible etiological factor in Amyotrophic Lateral Sclerosis” that appeared in the journal Medical Hypotheses, suggests that nerve fibers that are disposed vertically (essentially oriented vertically) can accumulate too much cell waste. This cell waste accumulation can lead to damage to the nerve cell and even to cell death. The findings suggest that the uneven distribution of nerve cell loss in PALS, can have something to do with the fact that vertically oriented nerve cell bodies (axons) consume about 2% more energy than transverse running axons.
This may not seem like much but over a period of months and years this 2% excessive energy consumption, due to gravity, may cause the accumulation of waste in vertically running axons. This can deteriorate and weaken nerve cells and can lead to the onset of ALS. Other factors such as using your right hand more frequently (if you’re right handed), or excessive exercising, or your diet, or even your emotional wellbeing can all affect the progress of ALS.
Ok, so how do I counter the effects of excessive energy expenditure? I can’t stop my nerve cells from using energy! There’re a few strategies that we can recommend:
Avoid repetitive movements and try to change your body’s orientation throughout the day. There’s a recurring link between the deterioration of the nerve cells we use most and ALS. Making small adjustments throughout the day may help reduce the energy expenditure of the same nerve cells.
Increase your intake of supplements that help your nerve cells produce energy. We recommend that you look at Simplesa AAKG+ or learn more about the Deanna Protocol.
Increase the intake of supplements for ALS that help eliminate cell waste (such as excess Glutamate) and that help reduce oxidative damage. Try Oxaloacetate from Natural Dynamix Endure DX. Also try Liposomal Glutathione one of the most powerful anti-oxidants available.
Engage in Moderate intensity exercise that is non-exhaustive and specifically designed for patients with ALS. Learn more here Exercise Program for ALS,
Do what you can to reduce stress and stay in reasonably good emotional balance. There are many natural remedies for ALS. Reduce coffee intake, practice Yoga and meditation, and develop a deeper spiritual life. You can also try natural Hemp Oil remedies. Proponents of Hemp Oil suggest that it may help with feelings of nervousness, anxiety, improved sleep and reduced pain.
The discoveries will continue to come. Each new finding will help our scientists complete this elusive puzzle and get us one step closer to a solution. The cure is out there. In the meantime, we can do what we can to reduce the rate of damage to our nerve cells. We can improve our exercise routine, our supplement intake, and our spiritual world. Choose to live your best life. Stay strong!
Pena, PhD., Ana. “Energy Demands to Counter Gravity in Vertical Neurons May Lie at Origin of ALS”, ALS NEWS TODAY, August 30th, 2019.
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
It’s been a controversial subject for years. Can exercise help or could it possibly hurt patients with ALS?
In a 2016 study, a group of patients suffering from ALS was evaluated on a structured home-based program. This structure home-based program, as the name implies, was conducted without the supervision of a physical therapist (Home-EX group) at home. The exercises consisted of muscle stretching, muscle training, and functional training for 6 months. At the end of the 6 months, the patients were evaluated by physical therapists based on ALSFRS-R (ALS Functional Rating Scale–Revised) scores. The Home-EX group was found to have a significantly higher respiratory function sub-score as well as a higher total score on the ALSFRS-R, when compared to the control group.(4)
These promising results and the findings of other similar studies have shown the importance of moderate-intensity exercise as a therapy to help prevent muscle weakness. Along with strengthening muscles, the studies found a variety of other benefits.
Benefits of Moderate-Intensity Exercise for Persons with ALS (1):
May facilitate healthy innervation (stimulation through nerves) of neurons and synaptic networks to slow degeneration of neurons, i.e. moderate-intensity exercise may slow progression of weakness in the body.
May help to maintain cardiopulmonary efficiency, muscle strength, and endurance without overstressing the muscles or neurological system.
Using exercises matched to physical ability may help persons with ALS maintain a high level of function and independence.
People with ALS who have participated in an exercise program have experienced longer maintenance of strength, respiratory capacity, and function compared to those that did not participate in an exercise program.
No harm from participating in moderate intensity exercise programs have been reported.
Based on these findings and other compelling studies (please see References below), Simplesa Nutrition embarked on a journey to create an exercise program that was effective, easy to follow and readily available to everyone suffering from ALS or other Neurodegenerative diseases. It was clearly evident that many PALS face real challenges when it comes to affordability and accessibility to specialized physical therapists. Therefore, delivering the expertise of a Board Certified specialist in Neurologic physical therapy along with providing basic exercise equipment became an indispensable part of a successful program.
We partnered with Julie Talkington, a Board Certified Specialist in Neurologic Physical Therapy and together we developed a structured exercise program that was tailored for all stages of ALS, specifically; Early, Middle, and Advanced stages of the disease.
The result of our collaboration is the “Exercise Program for ALS”. The Exercise Program is designed as an at-home, step-by-step exercise guide for those suffering from ALS or other similar neurodegenerative diseases. Each exercise is clearly explained and is easy to follow and include illustrations for the beginning and ending movements. Each exercise is designed to target specific muscle groups in a systematic manner to maintain mobility and avoid overuse of these muscles.
The “Exercise Program for ALS” is a carefully vetted selection of 50+ exercises and stretches designed to strengthen and increase range of motion of specific muscles and muscle groups. The full Program is comprised of a 40 page Manual that comes complete with General Guidelines, easy to follow, step-by-step instructions and illustrations for each exercise, energy Conservation Techniques and even Breathing Techniques. The Program also includes a set of 3 Exercise Rubber bands, of different resistance levels and a small Exercise Ball for hand squeezing and other exercises.
It is our firm belief that PALS can benefit from this program as it provides an additional set of tools to help fight this disease. We invite you to try the program and if you’d like, provide us with welcome feedback. Please click here to learn more.
A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis
Andrew J Lui, Nancy N Byl JNPT Vol 33, June 2009 p68-87
Physical Therapy for a Patient Through Six Stages of Amyotropic Lateral Sclerosis
Vanina Dal Bello-Haas, Anne D Kloos, and Hiroshi Mitsumoto. Phys Ther. 1998: 78; 1312-1324
Effectiveness of Home-Based Exercises Without Supervision by Physical Therapists for Patients with Early-Stage Amyotrophic Lateral Sclerosis: A Pilot Study
Kitano, Kosuke et al.
Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 10, 2114-2117
Those living with ALS experience a vast and varying degree of complications that accompany the disease. Although there have been extensive advancements with remedies, treatments, and devices, resources are limited and complex. Daily living proves difficult in even the simplest tasks. Yet, not everything must be so difficult. Here’s a list of simple and natural ways to help you with your symptoms and overall wellbeing.
Eat a Nutritional Diet – The most important part of a nutritional diet for PALS is to remove toxins and eliminate the risk of damaging motor neurons by free radicals. Remove all sugars and processed foods1. Next you will need to introduce nutrient-dense and whole foods filled with antioxidants, vitamins, and minerals. Organic foods like free range chicken, grass-fed beef, healthy fats, and fruits and vegetables are examples of quality nutritional foods.
Exercise – To help prevent atrophy, improve mobility, and strengthen muscles, non-exhaustive exercise has shown to be beneficial in patients with ALS. Typical exercise regiments should consist of aerobic exercise, breathing exercises, stretching, and light resistance movements. Also, for those in more advanced stages of ALS, caregiver assisted stretching is beneficial to prevent pressure point sores and contractures. Overall, exercise for ALS may slow progression of motor neuron degradation, help patients maintain a high level of function, and improve respiratory capacity3. It is advised to seek a professionally developed program designed by a licensed physical therapist.
Occupational Therapy – This type of therapy provides rehabilitative care for activities required in daily living to patients recuperating from a physical or mental illness. Difficulties that occur for patients with ALS such as bathing, dressing, swallowing, and walking are fundamentally improved through programs of occupational therapy. Assisted devices, tools, and clothing, which can facilitate mobility and daily activities, are easily accessible. Studies show that people with ALS involved in multidisciplinary programs have longer life spans, due to social involvement and better mental health4.
Supplements – A great way to ensure ALS patients are getting the appropriate vitamins, minerals and nutrients is through supplements for ALS. Avoiding malnutrition and ensuring an adequate dietary intake is a key factor in preventing atrophy, infection, and a weakened immune system5. Antioxidants and detoxifiers are equally important for preventing damage from oxidation and free radicals. Although there are various supplements that are recommended for patients with ALS, some of the more notable ones are Vitamin E and C, Vitamin B-complex, AAKG, GABA, Ubiquinol, Niacin, Vitamin D, CoQ10, Calcium, Magnesium, Selenium, Zinc, and fish oil1. The best supplements for ALS provide several benefits such as: energy production, detoxification, maintaining bone and muscle mass, improving cellular and mitochondrial function, and more1. You can find many of these supplements at simplesanutrition.com.
Emotional Support – The burdens of ALS do not only affect the body, but places a heavy toll on mental and emotional health. The stress of coping with a debilitating disease is difficult to manage. Support from family and caregivers is essential to emotional well-being. For help with managing stress, depression or anxiety it can be very helpful to work with a therapist trained in cognitive behavioral therapy, which emphasizes the importance of underlying thoughts in determining how we feel and act6. There are also various support groups and forums where you can speak to others in similar circumstances.
Sleep and Rest – One of the various struggles in managing ALS is constant exhaustion compounded by the inability to get restful sleep. The lack of sleep can cause another layer of complications to add to the already difficult effects of ALS. To prevent this restless cycle, there are some tips to help you secure better sleep. Some of these activities are: being active during the day, aromatherapy, eating foods that increase serotonin and melatonin, taking magnesium, adhering to a sleep schedule, drinking tea, taking a warm bath, exercise, meditation, reading, and taking soothing natural herbs. Other remedies for trouble sleeping due to pain include muscle rubs using lavender and peppermint oils, massage therapy and acupuncture, Epsom salt baths, and foam roller exercises, with the approval of a physical therapist. New remedies such as Hemp-Oil show promise in soothing and calming patients and getting them in a more restful mindset.
This is not an all-encompassing or complex list of suggestions for help with your ALS systems, but rather a simplified and natural way to tweak your daily routine. Make changes and introduce new habits at a rate that is comfortable for you. These tips can be implemented easily and may have significant improvements on living with ALS. Stay strong!
It is widely understood by the ALS community that there are limited solutions for the treatment of this devastating disease. The widely varying progression from patient to patient makes it difficult to standardize the appropriate approach. Not enough information is known and not enough research has been done. Pharmaceutical drugs are costly, cumbersome, and the benefits are often marginal.
An alternative approach to pharmaceuticals (or even an additional approach to pharmaceuticals), is to ensure that the body has the essential supplements for ALS and nutrients that it needs to help protect against the progress of this disease and to also provide much needed energy to the cells. Often, the worst case scenario with supplementation is that nothing perceivable happens, or that there are very mild side-effects from taking these supplements, many of which already occur naturally in the body. The best case scenario, however, can be delayed disease progression, reduced severity of the symptoms, and an overall improved quality of life.
The Deanna Protocol (DP), created by Dr. Vincent Tedone, is one such approach. This Protocol was initially based on Dr. Tedone’s research with his daughter, Deanna, who was diagnosed with ALS nearly 10 years ago. According to Dr. Tedone, the DP works because it provides two primary mechanisms of action. The first, is that it provides the body with the nutritional supplementation it needs and that allows the body to properly metabolize and remove excess glutamate, the leading cause of nerve cell death. The second mechanism, is that the DP provides nerve cells (neurons) with additional energy that help keep the neurons healthy and functioning for longer.
The Deanna Protocol consists primarily of the following naturally occurring supplements:
AAKG and AKG (Arganine Alpha Ketoglutarate) AKG is the key supplement providing energy to the cells and is required by the body to keep cells alive. The Arganine in AAKG improves the palate of the AKG and makes it easier on the stomach. Arganine also produces the free radical, nitrous oxide (NO). The NO can increase blood flow, which possibly assists in the removal of excess glutamate in the blood stream. Excess glutamate is the cause of cellular death in ALS. Those with preexisting heart conditions should consult with their physician before consuming arginine.
Ubiquinol (CoQ10) helps the energy cycle in mitochondria and is known for its antioxidant properties. Oxidative stress and mitochondrial dysfunction have been implicated in the pathophysiology of ALS. CoQ10 also promotes energy and overall vitality and helps normalize circulation.
Niacin and 5-hydroxytryptophane are precursors to NADH, which is unable to be absorbed by the GI system. NADH is essential in several of the reactions of the energy cycle and is also important in transporting electrons.
GABA is an inhibitory neurotransmitter. In patients with ALS, excitatory and inhibitory neurotransmitters are out of balance, which necessitates the addition of GABA. This balance of neurotransmitters reduces anxiety and rigidity of the muscles.
Glutathione is critically important for detoxification. With its anti-inflammatory properties, it’s considered one of the most important antioxidants in the healthy functioning of cells. The body uses glutathione to protect against toxins. Cells deficient in glutathione have difficulty defending against toxins in food, pollution, radiation, carcinogens, heavy metals, and drugs.
These supplements for ALS, when combined in the appropriate doses and quantities as provided by Simplesa Nutrition, can detox the body and may improve mobility, reduce pain, increase energy, and a plethora of other health benefits. It’s often up to you, the patient with ALS, in association with your doctor, to determine the best treatment protocol or combination of protocols that works best for you. Consider nutritional supplements as an additional support in your fight against neurodegenerative diseases.
1. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.
2. ALS News Today: To ‘B’ or Not to ‘B’?. July 25, 2018 by Rick Jobus
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
Phase 2 Trial of FLX-787 has stopped, but there is still hope for those suffering from muscle cramps!
About a year ago, the U.S. Food and Drug Administration granted fast track status to Flex Pharma’s treatment for severe muscle cramps in ALS, FLX-787. Flex Pharma has just announced the cease of research and clinical trials of FLX-787.
The Phase 2 trial in the US was evaluating the effectiveness of FLX-787 administered at 30mg three times a day in comparison to placebo. The desired result is an overall reduction in muscle cramps.
Although there were some promising results, there were tolerability issues with the formulation and dosage. Now Flex Pharma is restructuring to lower costs and cutting its workforce by nearly 60 percent. The future is on hold and uncertain with FLX-787.
Other solutions exist. There is still hope to diminish or eliminate some of the musculature symptoms that accompany ALS. The Deanna Protocol by Dr. Vincent Tedone has demonstrated numerous cases of anecdotal evidence that decreases the overall symptoms of spasticity and fasciculation. Not only does it help motor neurons function properly, but has shown promising results in helping the body delay the advancement of the disease by reducing cell death.
In addition, existing ALS clients adhering to the Deanna Protocol, as formulated by Simplesa Nutrition, have reported very good tolerability of the supplements with little to no discomfort or side effects. It would seem that the strategy to help your body heal itself (or at least help it fight a better fight) by providing it with the necessary nutritional supplements is still a worthwhile option.
The moral of the story is to stay in the fight and seek alternative treatments. There are existing and continuously evolving solutions out there to help improve the quality of life of those suffering from ALS and other neurodegenerative diseases.
1. ALS News Today: Flex Pharma Stops Phase 2 Trial of FLX-787 to Ease Muscle Cramps in ALS Patients. June 15, 2018 by Jose Marques Lopes, PHD
2. ALS News Today: FLX-787, Which Treats ALS-Associated Muscle Cramps, Wins FDA Fast Track Status. July 26, 2017 by Carolina Henriques
3. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.
On May 30th 2018, the President signed the recently passed Right to Try (RTT) legislation into law. This new law allows patients to receive unapproved medications without FDA notification for up to one year. It also removes the FDA from prohibiting access to an experimental therapy and removes the FDA from advising on dosing, schedule, method of administration or other important safety measures. In short, you’re able to side step the FDA and go directly to the drug manufacturer. You’re basically on your own without the oversight of the FDA. So, Caveat Emptor (buyer beware) and proceed with caution.
Nevertheless, this opens up the door to new possibilities that were simply not available before.
Here’re some of the Pros and Cons as we see them.
Finally, some options. The RTT provides a level of freedom…and hope, that would otherwise be denied patients of terminal diseases.
Some of the therapies may prove beneficial and/or point the investigators and drug companies in a better direction.
It’s the right of every individual to choose their own destiny.
Side stepping Governmental bureaucracy and perhaps accelerating therapies that show promise.
Patients can try other drugs, supplements and therapies and report their results to their physicians and drug companies. Now information can flow in more directions.
The ALS Association both welcomed and voiced reservations about RTT. The association is aware of and is tracking this new law and will communicate with the ALS community.
Since the drugs are experimental and not FDA approved, this MIGHT lower treatment costs, as pharmaceutical companies cannot make a profit on these drugs until they’re FDA approved.
Possible access to other treatments and drugs, available outside the US, that have shown promise in other countries.
Some medications may not be safe, although they must have passed Phase 1 of clinical trials before patients of RTT can try the drugs.
Patients must look out for “bad actors” stepping in now to take advantage of patients vulnerabilities. Check history and reliability of manufacturer.
Pharmaceutical companies have very little incentive to provide access or broadly distribute their meds since they cannot make money until the drugs are FDA approved.
The RTT law could weaken current patient protection laws enforced by the FDA.
The reality is that many experimental drugs have limited access and availability anyway.
The RTT law may work as a pressure release valve and may reduce pressure on the FDA to speed up approval of Phase 1, 2 and 3 drugs in the pipeline.
Patient has little to no legal safeguards in case therapy produces more harm than good.
All in all, we think that the net effect of the new RTT law will be a positive one. This law opens up the conversation about the FDA’s unjustifiably slow and expensive process and provides the patient with some control over their destiny. That being said, patients need to be careful not to make a bad situation worse and should continue to consult with their physicians before venturing into unexplored territories.
ALS News Today: US “Right to Try” Law meets with mix of Praise and Criticism, Including Among Those with Rare Diseases.” June 4th, 2018 by Larry Luxner
Let’s be honest, when you hear or read the word Cannabis, Hemp, CBD, Marijuana, what comes to mind? Some people giggle, others cringe, some get offended. Now, there’s an increasing group of ex-sceptics, including reputable researchers, who contemplate and study the POSSIBILITIES.
Understanding how marijuana and the brain’s own natural cannabinoid system works is helping researchers design new medicines.
Cannabinoid expert Daniele Piomelli, PhD, of the University of California in Irvine. Says, “It’s believed that the controlled therapies that come out of this research might provide select benefits to patients while avoiding some of the unwanted effects seen with the drug.”
Research from California Pacific Medical Center in San Francisco points to the promise of marijuana-like treatments for those with the fatal brain disorder ALS, also known as Lou Gehrig’s disease.
We all know new treatments for ALS are desperately needed.
ALS wreaks its havoc by harming nerve cells and patients experience progressive muscle weakness that can hinder movement, speech, even swallowing and breathing. The only FDA approved drug for ALS, Riluzole (marketed as Rilutek), extends life on average by about two months,” says Abood. “Evidence from our study suggests that a marijuana-based therapy could create a much greater effect, perhaps extending life by three years or more.”
In the study, ALS mouse models were given either the marijuana compound THC, the marijuana compound cannabidiol, cannabidiol plus THC, or a placebo daily following the onset of disease signs. The researchers measured disease progression by testing how long the mice could stand on a slowly rotating rod. The more severe their nerve cell degeneration, the less time the mice can balance on the rod. In addition, two conditions of ALS, the loss of movement ability and survival time, were analyzed using a mathematical model.
“We found that treatment with THC delayed disease progression by seven days and extended survival by six days in the mouse model,” says Abood. “This corresponds to three years in human terms.”
Another part of the study determined that the marijuana compounds create their benefits by reducing two molecular processes, known as oxidative stress and glutamate excitotoxicity. These processes have been implicated in ALS and are thought to harm nerve cells.
Other Neurodegenerative conditions
Another animal study also indicates that a marijuana-like compound can protect brain cells from the damage produced by the disorder Parkinson’s disease.
“For the first time, our research shows the neuroprotective value of marijuana-like compounds in a well-established animal model of Parkinson’s disease,” says study author Andrea Giuffrida, PhD, of the University of Texas Health Science Center in San Antonio.
As a next step, the researchers are testing whether the marijuana-like compounds have neuroprotective value when brain cell damage is already present and whether they can prevent the progression of brain cell loss. “Learning more about the mechanisms by which marijuana-like compounds may slow down or prevent neurodegeneration in Parkinson’s disease may translate into new pharmacological treatments that could fight this disorder in its earliest stages,” adds Giuffrida.
If you or a loved one could have a better quality of life through your ALS ordeal, would you say yes to Cannabis?
To understand what the differences between Pharmaceutical and Nutraceutical are, we should begin with their definitions:
Relating to medicinal drugs, or their preparation, use, or sale.
a compound manufactured for use as a medicinal drug.
Plural noun: nutraceuticals
a food containing health-giving additives and having medicinal benefit.
Now, let’s compare the new drug approved by the FDA Radicava® vs The Natural alternative for a better quality of life, the Deanna Protocol®.
10 Things to Know About the New ALS Drug Radicava®
It is a Pharmaceutical drug.
The drug underwent a phase 3 clinical trial in Japan and South Korea where 137 ALS patients were given either Radicava® or a placebo. The group given Radicava® experienced a 33 percent reduction in the decline of their physical abilities compared to the placebo group.
Radicava® works by reducing the oxidative stress in the body. People with ALS have high levels of oxidative stress.
Radicava® is administered via intravenous infusions. Initially, patients have a daily infusion for two weeks and then have two weeks’ rest. After that, they need to have 10 consecutive daily infusions followed by two weeks of rest.
Each infusion takes around an hour to complete.
The dosage of each infusion is 60 mg.
The cost of each Radicava® infusion is about $1,000 and it’s reported that the treatment costs about $146,000 annually.
Radicava® should be available to ALS patients in the U.S. by August.
The most common side effects associated with the drug are headaches, bruising and gait problems.
Radicava® infusion contains sodium bisulfite which is known to cause both mild and severe allergic reactions in some people (particularly those with asthma).
10 Things to Know About the Deanna Protocol®
It is a naturally derived Nutraceutical program.
Developed by Doctor Vincent Tedone, a retired physician (Orthopedic Surgeon), for his daughter Deanna who was diagnosed with ALS at the age of 30 in 2007.
The Deanna Protocol® has undergone double blind clinical trials at the University of South Florida in mice models. The Deanna Protocol® has over 1,500 anecdotal case studies from patients with ALS.
The Deanna Protocol® is a blend of nutritional powders and liquids that contain powerful antioxidants and amino acids essential to assist your body in its natural efforts to fight neurodegenerative damage. People suffering from other neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, have also reported improvements.
It is taken in the morning, in the afternoon and at night as part of your regular, at home, breakfast, lunch and dinner routine. No need to go to the clinic.
The Protocol is the same for everyone but the dosages might vary, depending on the person and what their specific needs are. The most common side effect is an upset stomach usually reported during the initial days as the body adjusts to the protocol.
The cost of the Deanna Protocol® starts at $219.99 for the Core Bundle #1. The next most inclusive package is the Plus Bundle #1 at $249.99. And our most inclusive bundle is the Comprehensive Bundle #1 at $349.99. Above prices are for a 1 month supply and include easy-to-follow, step-by-step instructions and an actual human to answer your questions and provide you with the support you need.
Not sure? At Simplesa’s website there’re 330+ reviews with 4.5 stars from verified and satisfied buyers at simplesanutrition.com or call 1-888-578-5528.
Deanna Protocol® has been in the market for almost 4 years. The popularity of the protocol and the positive reports from the clients, speak for themselves.
The freshness of the products used in the Deanna Protocol is guaranteed, these products are naturally derived and are manufactured in a facility that follows strict Current Good Manufacturing Practice (cGMP) (Enforced by the FDA) and is UL (Underwriters Laboratories) certified.
This Blog is for educational purposes. We hope that the above information helps you make the right decisions to address your neuro-degenerative concerns. And as always consult your physician.
If you liked this article, please share with others
that could benefit from this information.
Remember Sharing is Caring!
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.
Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.
What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.
Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.
Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.
Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions. An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.
As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.
Do I have a B12 deficiency? Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:
· strange sensations, numbness, or tingling in the hands, legs, or feet
· difficulty thinking and reasoning (cognitive difficulties), or memory loss
· paranoia or hallucinations
While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.
How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin. Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.
Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain. Simplesa Liposomal Vitamin B12 does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.
Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it.  Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.
Some of the many benefits of Simplesa Liposomal Vitamin B12:
· Contributes to normal red blood cell formation
· Supports the nervous system and mental functions
· Contributes to a normal, healthy metabolism
· Is essential for a healthy heart
Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil. It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.
For more information or to try our new Simplesa Liposomal Vitamin B12 click here.