Category Archives: Blog

Woman with depression seen looking out a window

Reduce Depression & Symptoms Naturally

Studies Say 50% of Those With Parkinson’s Experience Depression. 

That statistic probably isn’t a huge surprise. Any neuro-health diagnosis is tough news to take.

What’s interesting is, those diagnosed often experience these symptoms long before any Parkinson’s symptoms show.

That’s because Parkinson’s (and diseases like it) affect chemicals in your brain. These changes may lead to mood disorders like depression, anxiety or lack of motivation.

Depression can also intensify other Parkinson’s symptoms.

Fortunately, there’s a natural supplement that may help. 

5-HTP (5-hydroxytryptophan) is a natural supplement that has been studied for its potential to help improve the symptoms of depression.

It is a natural derivative of the amino acid tryptophan and scientists believe it increases the level of serotonin, a neurotransmitter in the brain that plays a role in regulating mood. 

Not only is 5-HTP known to help those suffering with mood disorders, it’s also shown to help reduce the symptoms of Parkinson’s disease.

Studies have also suggested that 5-HTP can increase dopamine levels.

Research has found that 5-HTP may help improve motor function and reduce tremor associated with the neurological condition.

That’s why we carry a specially sourced high quality 5-HTP supplement in our store. 

It’s also available as part of our comprehensive neuro-health bundles on this page.

You’ll find it comes in easy to swallow capsules that have been scientifically formulated for potency and absorption.

Some Medications Deplete This Vitamin

Yet, this vitamin is also a core marker used by doctors to help diagnose neurodegenerative diseases.

It’s also known to be a contributor to depression, sleep problems, cognitive decline and even heart disease… Yet 20% of those over 65 experience some level of depleted Vitamin B9.

Many programs have been put in place to add extra folate and folic acid to foods, but not all of it is easily absorbed. That’s why a special type called Quatrefolic was created.

Did you know that a lack of folic acid is a core marker for neurodegenerative diseases?

Both Vitamin B12 (Cobalamin) and Vitamin B9 (Folic Acid) are incredibly important to the bodies homocysteine levels which help protect against circulation problems. 

People with low levels of these vitamins have more tingling in their hands, feet, arms and legs. They get more canker sores in their mouth, headaches and dizziness.

It’s also a big contributor to high blood pressure, higher cholesterol levels and poor blood sugar levels. 

Either way, the good news is… it’s not hard to add these important vitamins to your diet.

You probably already get enough Vitamin B12 by eating meat, fish or dairy products, but Vitamin B9 is a little tougher, since not all of it is readily available to the body.

That’s why our Opti-Max Multivitamin includes Quatrefolic®. It’s a specially designed folic acid (B9) that’s more effective than the types found in food. 

We feel it’s also more convenient to take alongside all the other well-researched vitamins known to help reduce the symptoms of aging and neurological disorders.

See More Information About It Here

Does this Indian spice combat inflammation?

Why This Spice is Controversial Among Some Researchers

There’s a lot of argument these days about the key ingredient in curry. It’s what gives the dish its yellow colour and many studies have shown its potential to reduce inflammation, help the immune system, fight free radicals and help slow disease.

Uncontrolled Inflammation is a big problem as we get older. Most modern doctors believe that low-level inflammation actually plays a key role in the progression of metabolic, heart (1), Alzheimer’s, and neurological diseases.

Yet not everyone agrees the spice deserves all its praise.

While it’s been in use for thousands of years in India, China, Taiwan and Indonesia, much of the benefits claimed by health experts over the years have been hard to prove. 

Some studies saw incredible results in a short period of time, and others saw fewer results. Curious why some didn’t see a difference right away? There’s a really good reason.

That’s because on its own, it doesn’t absorb well in the body. 

It helps to consume it with black pepper (like BioPerine) a natural substance shown to enhance its absorption by 2,000% (2) and take enough to see a difference.

The other challenge is, while it’s commonly found in many foods, you’d have to eat a lot of them to see benefits (3). Still, a trusted old spice like Tumeric is safe and convenient, when taken as a supplement.

Turmeric is actually part of the ginger root family, and ginger is also known to have long-term anti-inflammatory benefits. 

That’s why when our team of scientists, doctors and care-givers discussed making a better Tumeric based supplement, we included these:

  • Turmeric Root Extract – a highly concentrated version of the active ingredient Curcumin.
  • BioPerine – to help boost the absorption of Tumeric itself
  • Ginger Root Extract – to help protect the brain, gut and support healthy inflammatory levels.

Together they help give the best possible natural anti-inflammatory mix for potency, quality and absorption. 

You can see our unique Tumeric Blend here. 

Modern sports teams, arthritis sufferers and many others take it regularly. They trust that it’ll help provide all natural relief without as many side effects as you might expect from non-natural or chemical alternatives.

References:
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636482/

2 https://pubmed.ncbi.nlm.nih.gov/9619120/

3 https://pubmed.ncbi.nlm.nih.gov/26007179/

Neuro-Health Protocol: Why Some Don’t Get Results

Caring for someone who’s managing a neurological condition is a difficult road. Sometimes it can feel like you’re doing all the right things and still not seeing a change in their symptoms.

While everyone’s body, genetics and situation are different, we wanted to take a moment and cover some of the aspects of Neuro-Health Protocol.

#1. Consistency

Taking the protocol on a consistent schedule helps ensure a consistent supply of the amino acids, nutrients and minerals that help relieve symptoms. That’s why our system is broken up into a morning, afternoon and evening dosage plan.

#2. Dosage

The amount of each supplement needed is different for everyone. Some are only moderately deficient of the amino acids and nutrients and will need less. You can increase the dosage of AAKG daily by two grams per day every day to a maximum level of 18 grams.

Our protocol for following the recommended dose schedule is on this page.

#3. Activity

It’s a good idea to encourage exercise to help stimulate and maintain the muscles. It’s not a good idea for those on the protocol to overdo it though… Even light resistance exercises and stretches are beneficial.

#4. Diet

Some research shows a mediterranean diet can boost energy and help deal with symptoms of neuro-health disorders. The main thing is to avoid foods high in saturated fats, processed foods or those high in sugar. It’s also best to avoid large amounts of alcohol or foods that require a lot of chewing energy.

#5. Supplements

The National Institutes of Health (NIH) has put together a list of recommended nutritional supplements for Parkinson’s (and similar neuro-health diseases) for daily use. Most of these vitamins and minerals and in the appropriate dosages for healthy adults are available in Total Health AM

While none of these are a cure, they’re often enough to help slow the progression and put you back in control.

The best thing we can do is increase the number of amazing memories and moments with our loved ones and increase quality of life.

See Our Recommended Vitamin Supplement Here

Quality Sleep Is Important

One specific hormone makes a big difference.

Did you know an estimated 1 in 3 adults struggle with sleep? Studies show the average person is now getting two hours less than the previous generation did.

Lack of quality sleep is tied to a long list of illnesses. In fact, it’s one of the early signs of diseases like Parkinson’s.

While everyone’s different, there’s a few possible reasons why. 

It could be that a reduced dopamine level can significantly impact the body’s natural sleep-wake cycle. For others, it can be impacted by sleep apnea, restless legs or frequent nighttime urination. 

Our bodies naturally produce a hormone that helps calm the nervous system, relieve stress and help provide a better nights rest. The problem is, people diagnosed with a neurological disease usually don’t produce enough.

A lack of this hormone is also shown to be a contributing factor to headaches, heartburn, mood swings, digestive problems, high blood pressure and so much more.

That’s why it’s included in our AAKG+ Core Protocol

We feel regularly getting extra Gamma-aminobutyric acid (GABA) is important as part of a healthy lifestyle.

Normally, you’d be able to boost production of this hormone with fermented foods. The problem is, you’d have to eat a lot of it.

That’s why the Core Protocol is so convenient.

It’s just one scoop, three times a day.

See The Core Blend Here

Can This Flu Fighter Slow Memory Loss Too?

Do We Have Anything More Precious Than Our Memories?

It’s a deep thought, but if you think about it, the precious memories of some of the most emotionally impactful moments of our lives are probably the most valuable thing we have in this life.

Being able to remember your wedding day, or even the first date. Recalling when your children were little, or those special christmases when they’re young and impressionable. If you lose almost everything else, those are what really matters.

If you’ve ever had the gift of spending time with someone who’s starting to see some memory loss, know how incredibly tough that can be.

One of the supplements on our website (Black Elderberry) is well known in the science community as an immunity helper, inflammation fighter and even an antioxidant. Some studies in a clinical trial showed that taking it shaved four days off the average FLU virus in people over 50, for example.(1)

BUT… Studies also show it helps improve memory function!

Some with ALS, Parkinson’s and other neurological disorders often demonstrate symptoms similar to Alzheimer’s, dementia and other memory loss disorders later in life.

The cause of these neurological disorders is unknown but, one thing we do know is they’re all caused by the amyloid plaques that collect between neurons and disrupt cell function. (2)

Could This “Flu Fighter” Help?

What’s exciting is that Black Elderberry was tested in animals with amyloid plaque build up, and their memory improved despite having Alzheimer-like symptoms. (3)

That study is fairly recent (2022) but… we know that the flavonoids in elderberries and elderflowers include quercetin, and are recognized for their ability to protect cells.

So, whether you’re looking for something that helps boost the immune system or something that could help with cognitive function and support the brain naturally, Black Elderberry is a great option.

See Our Concentrated Black Elderberry Here

References:
https://pubmed.ncbi.nlm.nih.gov/9395631/
https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease
https://journals.sbmu.ac.ir/Otolaryngology/article/view/39095

Why Many Doctors Are Still DiscoveringThe Incredible Benefits of AKG and AAKG

In the 17th century, Captains sailed from port to port trying to outrun Scurvy. The British Navy alone lost 133,000 sailors to it. It wasn’t until the 1960’s when clinical trials clearly demonstrated it was curable by access to fresh fruit or Vitamin C.

Modern antibiotics were available in ancient Egypt, but modern doctors didn’t discover and administer them until the 1950’s. 

L-arginine, AAKG and AKG like this one are still ‘new’

When you consider how fast scientific research is funded, conducted and released to the public, these supplements are a very recent discovery.

The unfortunate thing is… not every substance and application that deserves testing and study is actually funded each year. 

The big question is… Should you trust that AKG could actually help?

Our bodies already produce high levels of Alpha-Ketoglutarate (AKG)… but after age 40, levels of AKG drop dramatically. Everyone’s body needs it, but it would be unrealistic to eat enough of the foods that could replace it.

AKG is responsible for at least 600 enzymatic reactions in our body. For instance, AKG is the primary enzyme group we use to make glutathione for our red blood cells.

New studies proving its benefits are released all the time. 

Here’s just some of them:

  • Alpha-ketoglutarate increases life span, reduces frailty and reduces inflammation in middle-aged mice (1)
  • AKG has been shown to have a protective effect against osteoporosis (2)
  • Dietary AKG may improve protein metabolism and synthesis in older adults (3)
  • When combined with Vitamin B, AKG may be essential in long-term nerve strength, memory, and neurotransmission (4,5)
  • In mice, AKG inhibited liver disease progression (5)
  • AKG has been shown to improve kidney function in patients with chronic renal failure (5)
  • Topical AKG reduces skin wrinkle formation by increasing collagen production (6)
  • AKG prevents skeletal muscle degradation and muscle atrophy (7)
  • AKG can prevent the brain from oxidative damage by increasing neuronal concentrations of antioxidative enzymes (8)

There’s no doubt that Alpha-Ketoglutarate has a lot of potential benefits… but the real question is… 

Does it matter where you buy it?

We think it does. You don’t always know where or how some brands source their ingredients. We’ve fought hard to find the most pure, easily absorbed and naturally sourced ingredients produced right here in the USA. 

Potency is important. That’s why you may not need as much of our AKG supplement as other brands.

You’ll also notice our AAKG+ Core Blend includes Vitamin B (niacin) which helps nerve strength as mentioned above. It also includes an easily absorbed CoQ10 supplement for brain & muscle health. 

If you or someone you love has been diagnosed with a brain, neurological or age-related condition, it’s worth trying a month’s supply (one container with 90 servings).

See our high potency AAKG+ Core Blend on this page.

Our AAKG+ formula has helped hundreds of ALS patients get results since 2014.

It’s also received over 590, 4.5+ Star Reviews from our customers!

There’s no better investment than health and quality of life.

References:
 
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30417-4
https://pubmed.ncbi.nlm.nih.gov/17896582/
https://pubmed.ncbi.nlm.nih.gov/32877690/
https://pubmed.ncbi.nlm.nih.gov/22846967/
https://doi.org/10.1016/j.tem.2021.11.003
https://doi.org/10.1248/bpb.30.1395
https://pubmed.ncbi.nlm.nih.gov/28939592/
https://pubmed.ncbi.nlm.nih.gov/27491897/

Antioxidant Helps Reduce Parkinson’s Symptoms and Boost Tissue Repair

Most of us produce less Glutathione as we age. Studies show those with neurodegenerative diseases like Parkinson’s produce even less than the average person.

It’s one of the most effective antioxidants available.

Our cells naturally produce free radicals as part of their metabolic process, but that’s amplified when exposed to toxins like x-rays, cigarette smoke, and other pollutants.

Free radicals are the largest source of electron damage in nerve cells.

Here’s an interesting number… A healthy body creates over 32 sextillion free radicals per day! When we age, our bodies slow down the creation of enzymes that break down free radicals. 

This daily build up of free radicals is one of several factors that lead to the neuron damage thought to play an important role in the progression of Parkinsons. (1)

Glutathione is one of the main antioxidants that slow down the process of cellular damage, although most won’t see benefit in taking it orally. That’s because the acid in our stomach would destroy most of it.

That’s what makes Liposomal Glutathione unique.

The supplement packages the antioxidant in a fat-like molecule that allows it to absorb better and is far less invasive than the injections offered at some clinics.

All those with multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and those diagnosed with Parkinson’s had substantial glutathione deficits. (3)

That’s why taking a supplement that may help reduce nerve damage and improve mobility could be a simple way to improve quality of life.

See our unique Liposomal Glutathione on this page.

References:
1. https://link.springer.com/chapter/10.1007/978-3-0348-7337-6_28
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751460/
3. https://pubmed.ncbi.nlm.nih.gov/14502663/

Why some people live so much longer than others

The Island Where People Live Longer

It’s Baffled Many Scientists…
Some Clues Show Why These Folks Live So Long

It’s no secret that some places have lower rates of Parkinson’s, ALS, heart disease or any other illnesses we commonly associate with old age. The amazing thing is, one such place is the island of Ikaria in Greece.

It’s a place where 2.5 times as many people live past the age of 90 (compared to the USA). Not only do the people of Ikaria live longer, they also live higher quality lives with fewer incidences of dementia or other neurological disease.

According to a study conducted by the Medical School of the University of Athens, Icarians live at least until their 90th year of age.

Cardiology Research and Study

You might think it’s the simple low-stress lifestyle that helps them live so long, but most of it has to do with regular exercise and diet.

Here’s some lessons we can learn from the Ikarian people:

  • Lower intake of saturated fat from meats or dairy
  • Regular use of olive oil which helps lower cholesterol
  • Eating wild greens and other antioxidants
  • A mediterranean diet with plenty of fish, vegetables and fruit
  • An afternoon nap which has been shown to decrease stress

What’s interesting is… L-arginine – The amino acid found in food that is what allows the body to produce AKG naturally – is found in most of the foods of Ikaria!

Foods like fish, chicken, beans, whole grains, nuts and seeds are all good sources of L-arginine. The sad thing is, we produce less AKG from these foods as we age. 

Countless studies have shown that AKG can help reduce symptoms associated with neurological diseases such as muscle spasms, but did you know it can also support healthy ageing? 

It’s been used to speed up wound healing times, protection for patients undergoing heart surgery and increase natural energy levels in athletes.

That’s why it’s at the core of our Core+ Blend Supplement.

Years ago, we discovered some of the supplements offering the same ingredient lacked the potency needed. We also felt there were a few other elements that would support neurological health as we age and support those struggling with some diseases.

We can’t all move to Greece, but we can definitely take some dietary, supplement and lifestyle changes to help live a better quality of life.

Energy Expenditure in Nerve Cells continues to be a Trigger for ALS

blue neurons als treatment

Finding a cure for ALS continues to be a difficult and elusive endeavor. This is understandable since the body is a complex system. Moreover, the degree of difficulty of finding a cure goes up exponentially, when one talks about the body’s nervous system. Nevertheless, advances and findings are coming to light rather quickly and we may be one piece of the puzzle away from a major breakthrough.

One cannot help but notice that within these new findings, certain similar themes that trigger ALS keep coming up. One such theme is the damage caused by the increase in energy expenditure by the nerve cells. A recent study called “Consideration of gravity as a possible etiological factor in Amyotrophic Lateral Sclerosis” that appeared in the journal Medical Hypotheses, suggests that nerve fibers that are disposed vertically (essentially oriented vertically) can accumulate too much cell waste. This cell waste accumulation can lead to damage to the nerve cell and even to cell death. The findings suggest that the uneven distribution of nerve cell loss in PALS, can have something to do with the fact that vertically oriented nerve cell bodies (axons) consume about 2% more energy than transverse running axons.

This may not seem like much but over a period of months and years this 2% excessive energy consumption, due to gravity, may cause the accumulation of waste in vertically running axons. This can deteriorate and weaken nerve cells and can lead to the onset of ALS. Other factors such as using your right hand more frequently (if you’re right handed), or excessive exercising, or your diet, or even your emotional wellbeing can all affect the progress of ALS.

Ok, so how do I counter the effects of excessive energy expenditure? I can’t stop my nerve cells from using energy! There’re a few strategies that we can recommend:

  1.  Avoid repetitive movements and try to change your body’s orientation throughout the day. There’s a recurring link between the deterioration of the nerve cells we use most and ALS. Making small adjustments throughout the day may help reduce the energy expenditure of the same nerve cells.
  2. Increase your intake of supplements that help your nerve cells produce energy. We recommend that you look at Simplesa AAKG+ or learn more about the Deanna Protocol.
  3. Increase the intake of supplements for ALS that help eliminate cell waste (such as excess Glutamate) and that help reduce oxidative damage. Try Oxaloacetate from Natural Dynamix Endure DX. Also try Liposomal Glutathione one of the most powerful anti-oxidants available.
  4. Engage in Moderate intensity exercise that is non-exhaustive and specifically designed for patients with ALS. Learn more here Exercise Program for ALS,
  5.  Do what you can to reduce stress and stay in reasonably good emotional balance. There are many natural remedies for ALS. Reduce coffee intake, practice Yoga and meditation, and develop a deeper spiritual life. You can also try natural Hemp Oil remedies. Proponents of Hemp Oil suggest that it may help with feelings of nervousness, anxiety, improved sleep and reduced pain.

The discoveries will continue to come. Each new finding will help our scientists complete this elusive puzzle and get us one step closer to a solution. The cure is out there. In the meantime, we can do what we can to reduce the rate of damage to our nerve cells. We can improve our exercise routine, our supplement intake, and our spiritual world. Choose to live your best life. Stay strong!

Source:
Pena, PhD., Ana. “Energy Demands to Counter Gravity in Vertical Neurons May Lie at Origin of ALS”, ALS NEWS TODAY, August 30th, 2019.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

The Benefits of Moderate-Intensity Exercise now Easier to Achieve than Ever for Patients with ALS (PALS)!

als exercise program

It’s been a controversial subject for years. Can exercise help or could it possibly hurt patients with ALS?

In a 2016 study, a group of patients suffering from ALS was evaluated on a structured home-based program. This structure home-based program, as the name implies, was conducted without the supervision of a physical therapist (Home-EX group) at home. The exercises consisted of muscle stretching, muscle training, and functional training for 6 months. At the end of the 6 months, the patients were evaluated by physical therapists based on ALSFRS-R (ALS Functional Rating Scale–Revised) scores. The Home-EX group was found to have a significantly higher respiratory function sub-score as well as a higher total score on the ALSFRS-R, when compared to the control group.(4)

These promising results and the findings of other similar studies have shown the importance of moderate-intensity exercise as a therapy to help prevent muscle weakness. Along with strengthening muscles, the studies found a variety of other benefits.

Benefits of Moderate-Intensity Exercise for Persons with ALS (1):

  • May facilitate healthy innervation (stimulation through nerves) of neurons and synaptic networks to slow degeneration of neurons, i.e. moderate-intensity exercise may slow progression of weakness in the body.
  • May promote a neuroprotective effect on the muscles.
  • May help to maintain cardiopulmonary efficiency, muscle strength, and endurance without overstressing the muscles or neurological system.
  • Using exercises matched to physical ability may help persons with ALS maintain a high level of function and independence.
  • People with ALS who have participated in an exercise program have experienced longer maintenance of strength, respiratory capacity, and function compared to those that did not participate in an exercise program.
  • No harm from participating in moderate intensity exercise programs have been reported.

Based on these findings and other compelling studies (please see References below), Simplesa Nutrition embarked on a journey to create an exercise program that was effective, easy to follow and readily available to everyone suffering from ALS or other Neurodegenerative diseases. It was clearly evident that many PALS face real challenges when it comes to affordability and accessibility to specialized physical therapists. Therefore, delivering the expertise of a Board Certified specialist in Neurologic physical therapy along with providing basic exercise equipment became an indispensable part of a successful program.

We partnered with Julie Talkington, a Board Certified Specialist in Neurologic Physical Therapy and together we developed a structured exercise program that was tailored for all stages of ALS, specifically; Early, Middle, and Advanced stages of the disease.

The result of our collaboration is the “Exercise Program for ALS”. The Exercise Program is designed as an at-home, step-by-step exercise guide for those suffering from ALS or other similar neurodegenerative diseases. Each exercise is clearly explained and is easy to follow and include illustrations for the beginning and ending movements. Each exercise is designed to target specific muscle groups in a systematic manner to maintain mobility and avoid overuse of these muscles.

The “Exercise Program for ALS” is a carefully vetted selection of 50+ exercises and stretches designed to strengthen and increase range of motion of specific muscles and muscle groups. The full Program is comprised of a 40 page Manual that comes complete with General Guidelines, easy to follow, step-by-step instructions and illustrations for each exercise, energy Conservation Techniques and even Breathing Techniques. The Program also includes a set of 3 Exercise Rubber bands, of different resistance levels and a small Exercise Ball for hand squeezing and other exercises.

It is our firm belief that PALS can benefit from this program as it provides an additional set of tools to help fight this disease. We invite you to try the program and if you’d like, provide us with welcome feedback. Please click here to learn more.

Resources:

  1. A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis
    Andrew J Lui, Nancy N Byl JNPT Vol 33, June 2009 p68-87
  2. Physical Therapy for a Patient Through Six Stages of Amyotropic Lateral Sclerosis
    Vanina Dal Bello-Haas, Anne D Kloos, and Hiroshi Mitsumoto. Phys Ther. 1998: 78; 1312-1324
  3. Effectiveness of Home-Based Exercises Without Supervision by Physical Therapists for Patients with Early-Stage Amyotrophic Lateral Sclerosis: A Pilot Study
    Kitano, Kosuke et al.
    Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 10, 2114-2117

The Nutritional Supplement approach to ALS!

A natural and cost-effective alternative.

supplements for als

It is widely understood by the ALS community that there are limited solutions for the treatment of this devastating disease. The widely varying progression from patient to patient makes it difficult to standardize the appropriate approach. Not enough information is known and not enough research has been done. Pharmaceutical drugs are costly, cumbersome, and the benefits are often marginal.

An alternative approach to pharmaceuticals (or even an additional approach to pharmaceuticals), is to ensure that the body has the essential supplements for ALS and nutrients that it needs to help protect against the progress of this disease and to also provide much needed energy to the cells. Often, the worst case scenario with supplementation is that nothing perceivable happens, or that there are very mild side-effects from taking these supplements, many of which already occur naturally in the body. The best case scenario, however, can be delayed disease progression, reduced severity of the symptoms, and an overall improved quality of life.

The Deanna Protocol (DP), created by Dr. Vincent Tedone, is one such approach. This Protocol was initially based on Dr. Tedone’s research with his daughter, Deanna, who was diagnosed with ALS nearly 10 years ago. According to Dr. Tedone, the DP works because it provides two primary mechanisms of action. The first, is that it provides the body with the nutritional supplementation it needs and that allows the body to properly metabolize and remove excess glutamate, the leading cause of nerve cell death. The second mechanism, is that the DP provides nerve cells (neurons) with additional energy that help keep the neurons healthy and functioning for longer.

The Deanna Protocol consists primarily of the following naturally occurring supplements:

AAKG and AKG (Arganine Alpha Ketoglutarate)
AKG is the key supplement providing energy to the cells and is required by the body to keep cells alive. The Arganine in AAKG improves the palate of the AKG and makes it easier on the stomach. Arganine also produces the free radical, nitrous oxide (NO). The NO can increase blood flow, which possibly assists in the removal of excess glutamate in the blood stream. Excess glutamate is the cause of cellular death in ALS. Those with preexisting heart conditions should consult with their physician before consuming arginine.

Ubiquinol (CoQ10) helps the energy cycle in mitochondria and is known for its antioxidant properties. Oxidative stress and mitochondrial dysfunction have been implicated in the pathophysiology of ALS. CoQ10 also promotes energy and overall vitality and helps normalize circulation.

Niacin and 5-hydroxytryptophane are precursors to NADH, which is unable to be absorbed by the GI system. NADH is essential in several of the reactions of the energy cycle and is also important in transporting electrons.

GABA is an inhibitory neurotransmitter. In patients with ALS, excitatory and inhibitory neurotransmitters are out of balance, which necessitates the addition of GABA. This balance of neurotransmitters reduces anxiety and rigidity of the muscles.

Glutathione is critically important for detoxification. With its anti-inflammatory properties, it’s considered one of the most important antioxidants in the healthy functioning of cells. The body uses glutathione to protect against toxins. Cells deficient in glutathione have difficulty defending against toxins in food, pollution, radiation, carcinogens, heavy metals, and drugs.

These supplements for ALS, when combined in the appropriate doses and quantities as provided by Simplesa Nutrition, can detox the body and may improve mobility, reduce pain, increase energy, and a plethora of other health benefits. It’s often up to you, the patient with ALS, in association with your doctor, to determine the best treatment protocol or combination of protocols that works best for you. Consider nutritional supplements as an additional support in your fight against neurodegenerative diseases.

Sources:
1.    Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.
2.    ALS News Today: To ‘B’ or Not to ‘B’?. July 25, 2018 by Rick Jobus
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

Medication for Muscle Twitching, Spasticity and Fasciculation Received a Setback

Phase 2 Trial of FLX-787 has stopped, but there is still hope for those suffering from muscle cramps!

About a year ago, the U.S. Food and Drug Administration granted fast track status to Flex Pharma’s treatment for severe muscle cramps in ALS, FLX-787. Flex Pharma has just announced the cease of research and clinical trials of FLX-787.

The Phase 2 trial in the US was evaluating the effectiveness of FLX-787 administered at 30mg three times a day in comparison to placebo. The desired result is an overall reduction in muscle cramps.

Although there were some promising results, there were tolerability issues with the formulation and dosage. Now Flex Pharma is restructuring to lower costs and cutting its workforce by nearly 60 percent. The future is on hold and uncertain with FLX-787.

Other solutions exist. There is still hope to diminish or eliminate some of the musculature symptoms that accompany ALS. The Deanna Protocol by Dr. Vincent Tedone has demonstrated numerous cases of anecdotal evidence that decreases the overall symptoms of spasticity and fasciculation. Not only does it help motor neurons function properly, but has shown promising results in helping the body delay the advancement of the disease by reducing cell death.

In addition, existing ALS clients adhering to the Deanna Protocol, as formulated by Simplesa Nutrition, have reported very good tolerability of the supplements with little to no discomfort or side effects. It would seem that the strategy to help your body heal itself (or at least help it fight a better fight) by providing it with the necessary nutritional supplements is still a worthwhile option.

The moral of the story is to stay in the fight and seek alternative treatments. There are existing and continuously evolving solutions out there to help improve the quality of life of those suffering from ALS and other neurodegenerative diseases.

Sources:
1. ALS News Today: Flex Pharma Stops Phase 2 Trial of FLX-787 to Ease Muscle Cramps in ALS Patients. June 15, 2018 by Jose Marques Lopes, PHD
2. ALS News Today: FLX-787, Which Treats ALS-Associated Muscle Cramps, Wins FDA Fast Track Status. July 26, 2017 by Carolina Henriques
3. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.

The Pros and Cons of the new “Right to Try” Law

On May 30th 2018, the President signed the recently passed Right to Try (RTT) legislation into law. This new law allows patients to receive unapproved medications without FDA notification for up to one year. It also removes the FDA from prohibiting access to an experimental therapy and removes the FDA from advising on dosing, schedule, method of administration or other important safety measures. In short, you’re able to side step the FDA and go directly to the drug manufacturer. You’re basically on your own without the oversight of the FDA. So, Caveat Emptor (buyer beware) and proceed with caution.

Nevertheless, this opens up the door to new possibilities that were simply not available before.

Here’re some of the Pros and Cons as we see them.

PRO’s:

  • Finally, some options. The RTT provides a level of freedom…and hope, that would otherwise be denied patients of terminal diseases.
  • Some of the therapies may prove beneficial and/or point the investigators and drug companies in a better direction.
  • It’s the right of every individual to choose their own destiny.
  • Side stepping Governmental bureaucracy and perhaps accelerating therapies that show promise.
  • Patients can try other drugs, supplements and therapies and report their results to their physicians and drug companies. Now information can flow in more directions.
  • The ALS Association both welcomed and voiced reservations about RTT. The association is aware of and is tracking this new law and will communicate with the ALS community.
  • Since the drugs are experimental and not FDA approved, this MIGHT lower treatment costs, as pharmaceutical companies cannot make a profit on these drugs until they’re FDA approved.
  • Possible access to other treatments and drugs, available outside the US, that have shown promise in other countries.

CON’s:

  • Some medications may not be safe, although they must have passed Phase 1 of clinical trials before patients of RTT can try the drugs.
  • Patients must look out for “bad actors” stepping in now to take advantage of patients vulnerabilities. Check history and reliability of manufacturer.
  • Pharmaceutical companies have very little incentive to provide access or broadly distribute their meds since they cannot make money until the drugs are FDA approved.
  • The RTT law could weaken current patient protection laws enforced by the FDA.
  • The reality is that many experimental drugs have limited access and availability anyway.
  • The RTT law may work as a pressure release valve and may reduce pressure on the FDA to speed up approval of Phase 1, 2 and 3 drugs in the pipeline.
  • Patient has little to no legal safeguards in case therapy produces more harm than good.

All in all, we think that the net effect of the new RTT law will be a positive one. This law opens up the conversation about the FDA’s unjustifiably slow and expensive process and provides the patient with some control over their destiny. That being said, patients need to be careful not to make a bad situation worse and should continue to consult with their physicians before venturing into unexplored territories.

Sources:

Cannabinoids to Treat ALS?

And OTHER Neurodegenerative Conditions

Let’s be honest, when you hear or read the word Cannabis, Hemp, CBD, Marijuana, what comes to mind? Some people giggle, others cringe, some get offended. Now, there’s an increasing group of ex-sceptics, including reputable researchers, who contemplate and study the POSSIBILITIES.

Understanding how marijuana and the brain’s own natural cannabinoid system works is helping researchers design new medicines.

Cannabinoid expert Daniele Piomelli, PhD, of the University of California in Irvine. Says, “It’s believed that the controlled therapies that come out of this research might provide select benefits to patients while avoiding some of the unwanted effects seen with the drug.”

Research from California Pacific Medical Center in San Francisco points to the promise of marijuana-like treatments for those with the fatal brain disorder ALS, also known as Lou Gehrig’s disease.

We all know new treatments for ALS are desperately needed.

ALS wreaks its havoc by harming nerve cells and patients experience progressive muscle weakness that can hinder movement, speech, even swallowing and breathing. The only FDA approved drug for ALS, Riluzole (marketed as Rilutek), extends life on average by about two months,” says Abood. “Evidence from our study suggests that a marijuana-based therapy could create a much greater effect, perhaps extending life by three years or more.”

ALSO SEE: Simplesa’s Hemp Oils (700mg + MCT, 900mg, and Full Spectrum)

In the study, ALS mouse models were given either the marijuana compound THC, the marijuana compound cannabidiol, cannabidiol plus THC, or a placebo daily following the onset of disease signs. The researchers measured disease progression by testing how long the mice could stand on a slowly rotating rod. The more severe their nerve cell degeneration, the less time the mice can balance on the rod. In addition, two conditions of ALS, the loss of movement ability and survival time, were analyzed using a mathematical model.

“We found that treatment with THC delayed disease progression by seven days and extended survival by six days in the mouse model,” says Abood. “This corresponds to three years in human terms.”

Another part of the study determined that the marijuana compounds create their benefits by reducing two molecular processes, known as oxidative stress and glutamate excitotoxicity. These processes have been implicated in ALS and are thought to harm nerve cells.

Other Neurodegenerative conditions

Another animal study also indicates that a marijuana-like compound can protect brain cells from the damage produced by the disorder Parkinson’s disease.

“For the first time, our research shows the neuroprotective value of marijuana-like compounds in a well-established animal model of Parkinson’s disease,” says study author Andrea Giuffrida, PhD, of the University of Texas Health Science Center in San Antonio.

As a next step, the researchers are testing whether the marijuana-like compounds have neuroprotective value when brain cell damage is already present and whether they can prevent the progression of brain cell loss. “Learning more about the mechanisms by which marijuana-like compounds may slow down or prevent neurodegeneration in Parkinson’s disease may translate into new pharmacological treatments that could fight this disorder in its earliest stages,” adds Giuffrida.

If you or a loved one could have a better quality of life through your ALS ordeal, would you say yes to Cannabis?

Sources: Science Daily, ALS News Today, Leafly

20 things to know regarding Pharmaceutical vs. Nutraceutical protocols for ALS!

Radicava® vs Deanna Protocol®

To understand what the differences between Pharmaceutical and Nutraceutical are, we should begin with their definitions:

phar·ma·ceu·ti·cal

Adjective

  1. Relating to medicinal drugs, or their preparation, use, or sale.

Noun

  1. a compound manufactured for use as a medicinal drug.

nu·tra·ceu·ti·cal

Noun

Plural noun: nutraceuticals 

a food containing health-giving additives and having medicinal benefit.

Now, let’s compare the new drug approved by the FDA Radicava® vs The Natural alternative for a better quality of life, the Deanna Protocol®.

  • 10 Things to Know About the New ALS Drug Radicava®
  1. It is a Pharmaceutical drug.
  2. The drug underwent a phase 3 clinical trial in Japan and South Korea where 137 ALS patients were given either Radicava® or a placebo. The group given Radicava® experienced a 33 percent reduction in the decline of their physical abilities compared to the placebo group.
  3. Radicava® works by reducing the oxidative stress in the body. People with ALS have high levels of oxidative stress.
  4. Radicava® is administered via intravenous infusions. Initially, patients have a daily infusion for two weeks and then have two weeks’ rest. After that, they need to have 10 consecutive daily infusions followed by two weeks of rest.
  5. Each infusion takes around an hour to complete.
  6. The dosage of each infusion is 60 mg.
  7. The cost of each Radicava® infusion is about $1,000 and it’s reported that the treatment costs about $146,000 annually.
  8. Radicava® should be available to ALS patients in the U.S. by August.
  9. The most common side effects associated with the drug are headaches, bruising and gait problems.
  10. Radicava® infusion contains sodium bisulfite which is known to cause both mild and severe allergic reactions in some people (particularly those with asthma).
  • 10 Things to Know About the Deanna Protocol®
  1. It is a naturally derived Nutraceutical program.
  2. Developed by Doctor Vincent Tedone, a retired physician (Orthopedic Surgeon), for his daughter Deanna who was diagnosed with ALS at the age of 30 in 2007.
  3. The Deanna Protocol® has undergone double blind clinical trials at the University of South Florida in mice models. The Deanna Protocol® has over 1,500 anecdotal case studies from patients with ALS.
  4. The Deanna Protocol® is a blend of nutritional powders and liquids that contain powerful antioxidants and amino acids essential to assist your body in its natural efforts to fight neurodegenerative damage. People suffering from other neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, have also reported improvements.
  5. It is taken in the morning, in the afternoon and at night as part of your regular, at home, breakfast, lunch and dinner routine. No need to go to the clinic.
  6. The Protocol is the same for everyone but the dosages might vary, depending on the person and what their specific needs are. The most common side effect is an upset stomach usually reported during the initial days as the body adjusts to the protocol.
  7. The cost of the Deanna Protocol® starts at $219.99 for the Core Bundle #1. The next most inclusive package is the Plus Bundle #1 at $249.99. And our most inclusive bundle is the Comprehensive Bundle #1 at $349.99. Above prices are for a 1 month supply and include easy-to-follow, step-by-step instructions and an actual human to answer your questions and provide you with the support you need.
  8. Not sure? At Simplesa’s website there’re 330+ reviews with 4.5 stars from verified and satisfied buyers at simplesanutrition.com or call 1-888-578-5528.
  9. Deanna Protocol® has been in the market for almost 4 years. The popularity of the protocol and the positive reports from the clients, speak for themselves.
  10. The freshness of the products used in the Deanna Protocol is guaranteed, these products are naturally derived and are manufactured in a facility that follows strict Current Good Manufacturing Practice (cGMP) (Enforced by the FDA) and is UL (Underwriters Laboratories) certified.

 This Blog is for educational purposes. We hope that the above information helps you make the right decisions to address your neuro-degenerative concerns. And as always consult your physician.

 If you liked this article, please share with others
that could benefit from this information.
Remember Sharing is Caring!

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.

Sources:
alsnewstoday.com
winningthefight.org
simplesanutrition.com/deanna-protocol/

 

B12 the Powerhouse Energy Vitamin – Try Simplesa Liposomal

Simplesa B12Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.[1]

What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.

Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.[2]

Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.[3]

Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions.  An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.

As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.[4]

Do I have a B12 deficiency?
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:

·         strange sensations, numbness, or tingling in the hands, legs, or feet

·         difficulty walking (staggering, balance problems)

·         anemia

·         a swollen, inflamed tongue

·         yellowed skin (jaundice)

·         difficulty thinking and reasoning (cognitive difficulties), or memory loss

·         paranoia or hallucinations

·         weakness

·         fatigue

While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.[5]

How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin.  Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.

Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain.  Simplesa Liposomal Vitamin B12   does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.

Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it. [6] Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.

Some of the many benefits of Simplesa Liposomal Vitamin B12:

·         Contributes to normal red blood cell formation

·         Supports the nervous system and mental functions

·         Contributes to a normal, healthy metabolism

·         Is essential for a healthy heart

Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil.  It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.

For more information or to try our new Simplesa Liposomal Vitamin B12 click here.

[1] https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
[2] http://www.health.com/health/gallery/0,,20924065,00.html
[3] http://www.medicalnewstoday.com/articles/219822.php
[4]  http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[5] http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[6] http://www.livestrong.com/article/289321-sublingual-vitamin-b12-vs-injectable-b12/

Lunasin and Its Benefits

Lunasin has been getting a lot of press, research and attention for benefiting a variety of health conditions. It is important to understand the science behind Lunasin, and how it can help your body.

Lunasin is natural, and found in soy, barley, and rye.  It is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus.

Proteins and peptides are fundamental components of cells that carry out important biological functions. Proteins give cells their shape, for example, and they respond to signals transmitted from the extracellular environment. Certain types of peptides play key roles in regulating the activities of other molecules. Structurally, proteins and peptides are very similar, being made up of chains of amino acids that are held together by peptide bonds (also called amide bonds).

So, what distinguishes a peptide from a protein?

The basic distinguishing factors are size and structure. Peptides are smaller than proteins. Traditionally, peptides are defined as molecules that consist of between 2 and 50 amino acids, whereas proteins are made up of 50 or more amino acids. In addition, peptides tend to be less well defined in structure than proteins, which can adopt complex conformations known as secondary, tertiary, and quaternary structures. [1]

Lunasin is a “bioactive” peptide which means it is a compound that influences living things and their core elements – like tissue and cells. Bioactive compounds have been shown via research and studies to have an influence on health. Areas of Lunasin research have focused on cancer, cholesterol, cardiovascular, inflammation, skin health and anti-aging.  Let’s examine these studies and how the science supports the benefits of Lunasin on your health and well-being.

Cancer

For over a decade research has shown “Lunasin as a cancer-preventive soy peptide.”[2] Memorial Sloan Kettering Cancer Center indicated that:

Studies in animals suggest that soy can prevent or reduce bone loss. In laboratory studies, iso- flavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. Animal studies showed that genistein, one of the isoflavones, may interfere with tamoxifen that is used for breast cancer. But a new study showed that soy foods can benefit women with breast cancer. Patients should consult their physicians about use of soy supplements.[3]

Skin Health

In 2017 a study stated that “The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells” and concluded that “Our studies suggest that Lunasin represents a unique anticancer agent that could be developed to help prevent metastasis and patient relapse by reducing the activity of CICs which are known to be resistant to current chemotherapies.”[4]

Cholesterol & Cardiovascular Health

The 2016 study “Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease” published by American Heart Association, Inc. found that:

Soy protein has an approved FDA health claim for reducing LDL cholesterol and CVD risk but the active component and mechanism of action are unknown. They tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol.

Using a lunasin bioactivity assay, we were able to produce a lunasin-enriched soy extract (LSE) containing 100-200-fold more bioactive lunasin than soy protein isolates. To test the in vivo efficacy of LSE, we conducted a food supplementation experiment on five pigs that have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE every day for eight weeks. Blood draws and lipid panel testing were done at -2w (before casein diet), 0w (2 weeks casein), 4w (4w casein + 250 mg LES) and 8w (8w casein + 250 mg LES). Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in case in diet reduced LDL cholesterol by 8.6% and 6.4% after 4 and 8 weeks of treatment, respectively. These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.[5]

Inflammation

Inflammation has an impact on all areas of health and well-being.

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic diseases such as cancer. Lunasin is a novel peptide that demonstrates potential anticancer activity against mammalian cancer cell lines and may play a role in inflammation. In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced.[6]

Although inflammation is linked in the public mind with chronic health problems such as heart disease, diabetes, and rheumatoid arthritis, de Mejia said it also plays a role in the development of cancer. “We know that chronic inflammation is associated with an increased risk of malignancies, that it’s a critical factor in tumor progression,” she said. “And we can see that daily consumption of lunasin-rich soy protein may help to reduce chronic inflammation.[7]

Obesity

A study in 2017 examined the relationship between inflammation and obesity. The study was called “Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production”.

This study indicated that lunasin is not only effective against inflammatory response of RAW264.7 macrophages, but also highlights this suppressive property on 3T3-L1 adipocytes, and disrupts the crosstalk between macrophages and adipocytes, particularly by inhibiting secretion of pro-inflammatory mediators, might benefit to ameliorate obesity-induced inflammatory diseases.[8]

Anti-Aging

Lunasin has been shown to help with anti-aging. Epigenetics shows the relationship of Lunasin to aging. Epigenetics is the study of long-term changes in chromosomes that don’t involve alterations in the genetic code.

But perhaps the most exciting area of aging epigenetics is the recent notion of an epigenetic clock, called Horvath’s clock, after its discoverer. The gist of it is that there is a strong association between the amount of genome-wide methylation and mortality. A lot of the genome is methylated when we are young but methylation is reduced in a constant clock-like way as we age. Methylation, recall, tends to silence genes. With age, it appears, an increasing number of genes that should be silenced are not, rendering us more susceptible to all manner of ailments. From reading the amount of methylation in the epigenome, scientists can predict an individual’s age with impressive accuracy.[9]

If you can utilize Lunasin to regulate or reset epigenetic implications of aging, then some studies believe we can reverse it.  One such study, examined this aspect of utilizing Lunasin for anti-aging. “Histone Modifications and Epigenetic Regulation Could Hold the Key to Reversing Aging” found that:

Results from a recent study conducted by researchers at the University of Pennsylvania show that yeast could help advance our progress in extending life in human cells. The team of researchers included Shelley Berger, PhD, professor in Cell & Developmental Biology and Biology & Genetics departments at the Perelman School of Medicine, Weiwei Dang, PhD, assistant professor at Baylor College of Medicine and former postdoc fellow at Penn, and Payel Sen, PhD, a current postdoc fellow in Berger’s lab. The study was published in Genes & Development and focused on how a certain epigenetic histone modification could extend yeast’s lifespan.

“Researchers have just started to appreciate how these epigenetic histone modifications may be playing essential roles in determining lifespan,” said Berger. She has conducted studies on epigenetic marks for more than 20 years and was one of the first to identify histone modifications that are altered during aging and directly impact longevity.

Dang explained that their study pinpointed a type of abnormal transcription that is significantly increased in older cells and, if reduced, can lengthen lifespan in yeast. He started the research when he was working in Berger’s lab.

He explained that “this longevity effect is mediated through an evolutionarily conserved chemical modification on histones [and] this is the first demonstration that such a mechanism exists to regulate aging.”

Although measuring aging in yeast is quite different from measuring human aging, Sen noted that using a budding yeast single-cell organism model turned out to be surprisingly powerful in their study of aging and epigenetic regulation.[10]

The research, science and benefits of Lunasin are clearly seen in these and many other scientific studies.

lunacell

 

 

Simplesa LunaCell™ is the most advanced Lunasin supplement on the market today. LunaCell has more than twice the concentration of bioavailable Lunasin than any other product available.  If you understand the science, then the choice is clear – choose LunaCell™!!

 

 

 

[1] https://www.britannica.com/demystified/what-is-the-difference-between-a-peptide-and-a-protein

[2] https://www.ncbi.nlm.nih.gov/pubmed/15730231

[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/soy

[4] https://www.ncbi.nlm.nih.gov/pubmed/28424421

[5] http://circ.ahajournals.org/content/126/Suppl_21/A10693

[6] http://www.sciencedirect.com/science/article/pii/S0196978109003416

[7] https://www.sciencedaily.com/releases/2009/12/091202153946.htm

[8] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171969

[9] http://goop.com/understanding-epigenetics-and-what-it-means-for-aging-cancer-and-obesity/

[10] https://www.whatisepigenetics.com/histone-modifications-and-epigenetic-regulation-could-hold-the-key-to-reversing-aging/

In Support of Parkland, Florida

As you may be aware, Simplesa is located in Coral Springs, Florida, the city adjacent to Parkland where the horrific school shooting took place earlier this week. Our thoughts and prayers go out to all those affected by the recent events. In support of our local community, Simplesa will be donating a portion of its proceeds for the rest of February to the victims and support efforts for those tragically affected. We invite you to join us in this cause.

simplesaparkland
In Support of Parkland, FL
For those customers looking to stock up on products before the end of the month, we are offering the following discounts:

Spend $200 during the rest of February and
get $15.00 OFF
use coupon code:
HEARTS4PARKLAND15

Spend $300 during the rest of February and
get $30.00 OFF
use coupon code:
HEARTS4PARKLAND30

Spend $500 during the rest of February and
get $65.00 OFF
use coupon code:
HEARTS4PARKLAND65

Spend $700 during the rest of February and
get $100.00 OFF
use coupon code:
HEARTS4PARKLAND100

parklandpromo

INTRODUCING OUR 2018 LOYALTY PROGRAM

We are pleased to launch our new 2018 Simplesa Loyalty Program. This program will enable you to earn rewards on your Simplesa purchases that can be used for discounts on future orders. Importantly, there is no expiration date on the points you earn. Get points for all your orders, and sometimes we’ll offer special opportunities to earn bonus points. You can keep track of your points by logging into your Simplesa account. Thank you for being a valued customer.

 

Simplesa Rewards Overview

SimplesaLoyalty

175 Points = $5 Voucher


330 Points = $10 Voucher


600 Points = $15 Voucher


900 Points = $25 Voucher


1,100 Points = $35 Voucher


1,500 Points = $50 Voucher


2,100 Points = $75 Voucher



2,600 Points = $100 Voucher


3,750 Points = $150 Voucher


4,000 Points = $200 Voucher


 

Start Earning Points

FREQUENTLY ASKED QUESTIONS
How do I enroll?
To enroll, you just have to create an account at SimplesaNutrition.com
Do I have to enroll if I am already a Customer?
We have already enrolled everyone with an active account and even rewarded you with 50 points to start the New Year.
When does the program begin?
The program begins January 1st, 2018

 

 

 

 

 

 

simplesafooteremail

Complementary Regimes of Lunasin and Deanna Protocol® for Veterans

VeteVrans Day is an important time to raise awareness of the ongoing health, physical and mental issues encountered by veterans during and after service. Recent studies show that veterans have a 60 percent higher risk of getting ALS than the general population.

“We don’t know what about service could lead to increased risk of the disease in veterans,” said Patrick Wildman, vice president of public policy for the ALS Association. “It could be a variety of factors from head trauma and excessive physical activity to exposures. It also could be a combination of a genetic predisposition with an environmental trigger.” The Mayo Clinic surmises that reasons for the connection “may include exposure to certain metals or chemicals, traumatic injuries, viral infections and intense exertion” but says that “exactly what about military service may trigger the development of ALS is uncertain.”[1]

These statistics are so staggering and alarming that Veterans Affairs has made ALS automatically service connected.

It doesn’t matter in which era the veterans served. From World War II through the Gulf War and even in peacetime, multiple studies show that the rate at which vets develop the condition is still twice as high as non-vets. In fact, the evidence is so convincing the Department of Veterans Affairs has assumed since 2008 that a veteran’s ALS is automatically service-connected.[2]

Finding ways to combat the onset or slow the progression of ALS is critical for patients with ALS (PALS) until a cure is found. Improving the quality of life for all those with ALS is a focus for Simplesa®.  The Deanna Protocol® (DP) is an all-natural metabolic program that works to support mitochondria dysfunction with energy production and counteracting oxidative stress. DP helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[3] Lunasin was the first dietary compound with an identified epigenetic mechanism of action. PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals. Research indicates that veterans with ALS and/or similar neurological issues have damage that is receptive to epigenetic therapies like Lunasin.

Dr. Richard Bedlack, Professor and Director of the ALS Clinic at Duke University, is conducting a study on Lunasin in 50 ALS patients. The study is a first of a kind clinical study that is investigating the efficacy of Lunasin in the support of ALS. It’s the fastest enrollment study ever conducted in their history. The clinical trial is based on Mike McDuff, an ALS patient who showed a remarkable reversal after taking bioactive Lunasin. He gained back his weight, went off his feeding tube and could talk again. Not all people will have the same results, but it greatly improved Mike’s quality of life.[4]

 

lunacell

Simplesa® is committed to helping veterans. They have a dedicated customer support staff of veterans to assist with questions about Simplesa’s Lunasin product called LunaCell™ and the Deanna Protocol®.

Simplesa® has always been steadfast to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. These two complementary regimes provide additional choices for PALS to help improve their quality of life.

For additional information on available veteran resources contact: http://www.pva.org

Sources:

[1] http://www.cnn.com/2015/11/11/health/als-and-military-veterans/index.html

[2] www.wearethemighty.com/veterans/military-veterans-are-twice-as-likely-to-get-als-and-no-one-knows-why

[3] www.mndassociation.org/wp-content/uploads/FINAL-WIP-booklet-Dublin-081116.docx

[4] lunasin.com/studies

 

Related Links

Deanna Protocol® Program for ALS

LunaCell

Related Video

http://www.youtube.com/watch?v=tOKoesaCh7M

Simplesa® is now offering the Deanna Protocol® and Lunasin to ALS Patients

Simplesa, a nutrition company established in 2013 after the amyotrophic lateral sclerosis (ALS) community showed its support for a metabolic supplement treatment called the Deanna Protocol (DP), has expanded its products for the Deanna Protocol with the addition of LunaCell™ for consumers.

Patients with ALS (PALS) have been following the Deanna Protocol (DP) since it was first released in 2011. The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone, a retired physician whose daughter, Deanna, was diagnosed with ALS. The Deanna Protocol works to support mitochondria dysfunction with energy production and the counteracting oxidative stress. The Deanna Protocol (DP) helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

lunacellLunasin first caught the attention of physicians and the ALS community when Mike McDuff, who was diagnosed with ALS, took the nutrient in 2012 and had a remarkable recovery. Therefore, Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[1] Lunasin was the first dietary compound with an identified epigenetic mechanism of action.  PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals.    Since that time, Lunasin has caught the attention of many trying to cure and/or treat ALS.  Among those interested in Lunasin and ALS is Dr. Richard Bedlack, Director of the ALS Clinic at Duke University. He started the first of its kind study on Lunasin with reporting conducted through a patient network and real-time research platform called Patients Like Me.

As with the Deanna Protocol, Simplesa saw the potential to help PALS with Lunasin.  Simplesa® recently released its Lunasin product, LunaCell™, which consists of a superior bioavailable form of Lunasin and is priced relatively lower than other Lunasin products. This formulation allows patients to take less capsules and quickly absorb more Lunasin into their system.

Feedback from verified consumers of the products has been very positive:

It seems impossible but after two days my dad muscle movement on leg that is useless for more than a year. – Andrej

 

I only take half of the capsules and it costs half as much as other Lunasin I took. Thank you. – Pedro O.

Simplesa® has always been committed to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. This new program is opening doors for additional choices for PALS to try both complimentary regimes and improve their quality of life.

Sources:

  1. Oxidative Stress and Radivcava: 

https://alsnewstoday.com/2017/08/03/nine-things-to-know-about-the-new-als-drug-radicava/

  1. Oxidative Stress and Lunasin:

https://core.ac.uk/download/pdf/3616328.pdf

  1. Oxidative Stress and Deanna protocol: 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103526

https://www.researchgate.net/publication/272828777_ALS_Untangled_No_20_the_Deanna_protocol

[1]www.mndassociation.org%2Fwp-content%2Fuploads%2FFINAL-WIP-booklet-Dublin-081116.docx&usg=AOvVaw0QgHpgvjCAB2Dae8-77Ins

Lyme Disease and ALS – Summer 2017

There is a lot of controversy regarding the connection between Lyme disease and ALS.

To understand the debate, let’s discuss some basics of both diseases as described by the experts.

lymediseaseimage

What is Lyme Disease:

Most people know that you get Lyme Disease from an infected tick, but many people don’t understand or realize the damage caused by Lyme Disease. If left untreated, the disease can lead to severe and life threatening medical issues.

“Lyme disease, the most common vector-borne illness in the United States, is a multi-system illness usually caused by infection with the spirochete Borrelia burgdorferi and the body’s immune response to the infection.[1] The disease is transmitted to humans via tick bites, from infected ticks of the genus Ixodes.”[1]

What is Amyotrophic Lateral Sclerosis (ALS)?

ALS is a progressive neurodegenerative disorder for which there is no cure.  Life expectancy following a diagnosis is two to five years.

“Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig’s disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) that are responsible for controlling voluntary muscles (muscle action we are able to control, such as those in the arms, legs, and face). This disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons.”[2]

How are these two diseases different?

ALS is currently an incurable disease. Lyme disease can be treated when discovered in a timely manner by antibiotics. If left untreated, Lyme disease can result in devastating medical problems and death. Lyme disease is known to mimic many of the symptoms of other diseases causing issues on diagnosis and subsequent treatment.

Because ALS and Lyme disease can exhibit similar symptoms, incidents of misdiagnosis of Lyme Disease as ALS have been reported.  This very recent case reported by NBC highlights a misdiagnosis of ALS when the patient actually had Lyme disease. The patient’s doctor insisted he had ALS, and they accepted the reality of this diagnosis.

“Matt remembered.”He said, “Enough’s enough. The reality is, you have ALS, and you know, you really need to embrace what I am telling you.” Matt’s family was told to help him come to terms with his death.

But inside their home, the Slatner family was doing their own research on Lyme symptoms and everything kept pointing to those tick bites.

“Every single thing is a Lyme symptom,” Stephanie said, remembering the long days and nights of research, three busy kids, and a husband who was slowly fading away. “No one would listen. I mean, they made us both feel like we were crazy.”[3]

Does everyone with ALS have Lyme?

“Lyme disease does not cause ALS, and generally in a diagnostic workup, a neurologist can easily separate ALS from Lyme infections, either clinically or with testing.”[4]

Despite the current belief that Lyme disease does not cause ALS, some studies have shown that many PALS do test positively for Lyme. This has caused a lot of disagreement between physicians and patients citing high statistical evidence of Lyme in many patients with ALS as more than just a coincidence.

Lyme Disease mimics other diseases

ALSLYME

( Image Ref: http://lymediseaseguide.org/wp-content/uploads/2011/07/lyme-disease-treatment-diagnosis.gif)

Does Lyme cause ALS? 

Many ALS patients have tested positively for Lyme disease, but not all Lyme patients develop ALS.  Currently, there is no definitive proof that Lyme disease causes ALS. Although often mistaken for ALS with similar symptoms, Lyme can be treated with antibiotics and other protocols dependent on the severity and progression. A cure for ALS still has not been found, but the Deanna Protocol has been shown to help with quality of life.

This topic continues to be a source of debate among physicians and PALS, with controversy evident on the internet and social media. If you are bitten by a tick, please seek medical attention immediately.

For more information on Lyme Disease: visit http://www.cdc.gov/lyme/

For more information on ALS: http://www.alsa.org/about-als/ 

[1] Ref: http://emedicine.medscape.com/article/330178-overview

[2] Ref: http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm

[3] http://m.nbc12.com/nbc12/db/345738/content/i7HSWfXF/gallery

[4] https://www.washingtonpost.com/opinions/five-myths-about-als/2014/08/22/70007ef2-2842-11e4-86ca-6f03cbd15c1a_story.html

Getting PALS the Help They Need FASTER!

ALS is an incurable disease at this time. When a patient and family is dealing with ALS, the last thing they should have to do is wait for financial and medical assistance. Currently, Social Security Disability Insurance (SSDI) has a typical 5-month waiting period for patients with ALS (PALS).

On Thursday, Feb. 16, Congressmen Seth Moulton (D-MA) and Peter King (R-NY) re-introduced The ALS Disability Insurance Access Act, bipartisan legislation they spearheaded to ensure that amyotrophic lateral sclerosis (ALS) patients are provided vital support and benefits in a timelier manner. The legislation would waive the Social Security Disability Insurance (SSDI) five-month waiting period for people living with ALS, commonly referred to as Lou Gehrig’s Disease.[1]

Many PALS are often diagnosed after they experience significant health deterioration and symptoms.  After dealing with the shock of this devastating diagnosis, PALS have to then apply for SSDI, which can be a lengthy and timely process. The ALS Association reports that fifty percent of all PALS succumb to their illness within 16 months of diagnosis.  The waiver of this 5-month waiting period to get sorely needed resources in an expedient and timely manner is critical.  “This legislation is especially important for people with ALS, for whom five months can mean the difference between life and death,” said Barbara Newhouse, President and CEO of The ALS Association.

The waiver implications go beyond just financial support. Medicare coverage is tied to the onset of the approval and start of SSDI.  The waiting period not only stalls much needed financial assistance to PALS and their families but also medical coverage for very costly care and potential medications.

We need your help to get this very important legislation quickly passed. You can send an e-mail to your members of Congress and personalize it with your story. Please urge your members of Congress to co-sponsor H.R. 1171/S. 379!  You can click here to send your support via the ALS Association website.

To track and monitor the status of this very important legislation you can visit the bill status on this website:   https://www.congress.gov/bill/115th-congress/house-bill/1171

Please see an excerpt of the bill here:

Bill History in the Congressional Record

Page numbers for legislative actions on this bill link to the Congressional Record. Learn more about the History of Bills and Resolutions.

From the Congressional Record, Volume 163 (2017)

——————————————————H.R. 1171–A bill to amend title II of the Social Security Act to     eliminate the five month waiting period for disability insurance     benefits for individuals with amyotrophic lateral sclerosis (ALS);     to the Committee on Ways and Means.  By Mr. MOULTON (for himself, Mr. King of New York, Mr. Bilirakis, Mr. Blumenauer, Mr. Cicilline, Ms. Clark of Massachusetts, Mr. Cohen, Mr. Conyers, Mr. DeFazio, Ms. DelBene, Mr. Engel, Mr. Garamendi, Mr. Heck, Mr. Jones, Mr. Keating, Mr. Kilmer, Ms. Michelle Lujan Grisham of New Mexico, Mr. MacArthur, Mr. McGovern, Mr. Peters, Ms. Pingree, Mr. Pocan, Miss Rice of New York, Mr. Richmond, Mr. Ruppersberger, Mr. Ryan of Ohio, Mr. Schiff, Mr. Sessions, Mr. Tonko, Mr. Walz, and Mr. Swalwell of California), H1300 [16FE]

If you need additional information on the bill or getting help read the original article form the ALS Association here:  http://www.alsa.org/news/media/press-releases/als-disability-insurance-access-act-021617.html

Please get involved today to CURE ALS and help PALS and their families improve their quality of lives.

[1] http://beverly.wickedlocal.com/news/20170220/moulton-king-continue-fight-for-als-patients

The Deanna Protocol® Continues to Impress ALS Patients

The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone which is continuing to improve the quality of life for people with ALS.

It was just a few years ago that the Ice Bucket Challenge caught everyone’s eye and raised awareness for ALS, or Lou Gehrig ’s disease.  At the time the Deanna Protocol® was relatively new but it was already helping many ALS patient’s lives.  According to a study by Winning the Fight, which researches “The Deanna Protocol,” a metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in an amyotrophic lateral sclerosis (ALS) mouse model.[1] The benefits of the Deanna Protocol to patients with ALS (PALS) is evident in the anecdotal feedback in recent years.

The Deanna Protocol® Metabolic Plan (also known as the DP™Plan) is a natural, drug-free, and inexpensive metabolic program developed for ALS. Scientific studies have proven that the DP™ Plan significantly slows the progression of ALS and extends life span. The DP™Plan is not an ALS treatment drug like Rilutek/Riluzole. It is a list of substances (AAKG, AKG, GABA, CoQ10, Niacin, and 5HTP) that are already found in the body. However, the amounts found in the body are not nearly enough for those who have ALS, so the DP™Plan provides the body and nerve cells with more of these substances to compensate for what they lack.  It is determined that the substances in the DP™ Plan provide energy to cells that are dying and in doing so keeps them alive.  This is very important because when nerve cells die, they release glutamate which kills the contiguous cells.[2]

In 2014 CBN News wrote that ‘Deanna Protocol’ Makes a Splash in ALS Research’. The study found “mice on The Deanna Protocol had improved neurological scores, increased motor function and most importantly, survived longer than the mice who weren’t on it.”[3]  Since this initial article, the Deanna Protocol has evolved in several major ways, in conjunction with assistance from Simplesa’s commitment to the ALS Community.  Simplesa® was founded in 2013 because it saw a need and had a solution.  ALS patients were having success following the Deanna Protocol, but it was too complex and expensive the way it was distributed. Simplesa® formulated products specifically for these ALS patients to simplify their regimen and lower the cost of the metabolic protocol.

Now all of the products needed to follow the protocol are offered in easy to follow combinations. Due to the improved ease of following the Deanna Protocol with the Simplesa products, the number of people following the protocol has increased. As the number of PALS following the Deanna Protocol has increased, Simplesa has also been able to reduce the cost of the protocol.  Additionally, to add further savings and flexibility to PALS, Simplesa® and Winning the Fight® teamed up to break the Deanna Protocol down into three bundled and more personalized options: Deanna Protocol Core, Plus, and Comprehensive Bundles.

The Deanna Protocol Core Bundle focuses on six essential nutrients of the Deanna Protocol. These nutrients primary support providing energy production to the body through the mitochondria of the cells.  The Plus Bundle builds on the Core Bundle by adding in Liposomal Glutathione, which helps the body push out toxins. It is considered the best antioxidant for the nervous system.  The Comprehensive Bundle builds on the Plus Bundle by adding in the AM & PM Blends. These blends come in two powders, one for the morning and one for the evening, and they contain an additional 20 amino acids that support muscle and nerve health. These combinations are based on the research publication by the NIH on nutrients that should be consumed by people who have ALS.

The affirmative feedback and reports from PALS to Simplesa® on the Deanna Protocol® have been very positive in the years since its inception.  PALS have continued to report improvement in quality of life:

“This product has worked wonders helping to reduce my pain, improve energy, lessen the severity muscle spasms, as well as improve balance and vertigo. I notice a day and night difference within taking my morning dose. I recommend taking the AKG throughout the day, not in lump 3 times a day to improve energy life.”

“My husband has been on the Deanna Protocol Products for two months now. He feels he has more energy and strength. We Would recommend these products!”

For more personal accounts on how the Deanna Protocol is helping PALS please click here.

The Deanna Protocol is not a cure for ALS, but it is a natural metabolic protocol that can help PALS improve their quality of life. To find out more about the Deanna Protocol® please contact Simplesa’s support team for information to see how it can help you or someone you know impacted by ALS.

References

*http://www.medicalnewstoday.com/articles/313919.php

[1] https://www.ncbi.nlm.nih.gov/pubmed/25061944
[2] https://www.winningthefight.org/deanna-protocolreg-metabolic-plan-for-als.html
[3] http://www1.cbn.com/cbnnews/healthscience/2014/August/Deanna-Protocol-Gains-Ground-in-ALS-Research