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I Dr. Googled Why My Muscles Won’t Cooperate Anymore

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If you’ve ever known anyone with ALS, it’s heart-breaking to watch.

One day they’re walking, cooking, doing yard work, and living a normal life. 

Next day, you watch as they keep tripping over the edge of the carpet… 

…can hardly make it through a meal without coughing……and their fingers refuse to close around a mug handle for a simple sip of coffee.

Every 90 Minutes Someone Gets the News…

Some catch it early. 

Most, like Paul, catch it in their 60s. 

“My wrist hurts when I twirl it around. I get tremors. Body twitching.”

“What bothers me the most is my face. My tongue won’t cooperate anymore. And my words are so slurred, my wife can’t understand me half the time. It’s insanely frustrating!”

And he knows it will only get worse.

His family dreaded the day in the future when Paul would likely not be able to walk or even breathe.

152 years after its discovery, ALS continues to strike without warning [3]. Every year, ALS turns the lives of 6,000 Americans into a living nightmare. [2]

It’s Like the Body Stops Listening To the Brain’s Command

While scientists can’t yet pinpoint why some people get ALS, they know the downward spiral is caused by nerve damage… 

Damage that chips away at the lining of a special type of nerve; motor neurons.

Think of motor neurons like the wiring that connects lights in your living room to a switch. Normally, you flip the switch, and all the lights go on. 

The problem is… once ALS shows up on the scene, these wires start to erode and deteriorate. 

One day you walk into your living room and flip the switch, expecting brightness. 

This time, only half the lights illuminate. 

The other light bulbs are still there. 

But they remain dark. Those wires failed.

They never heard the command to turn on. 

A similar thing happens to the motor neurons connecting the brain to the spinal cord of an ALS patient.

Once ALS shows up on the scene, these wires (motor neurons) start to erode and deteriorate.

It’s a tidal wave that forces more neurons off the grid. They lose their ability to talk to muscles in the arms, legs, chest, throat and mouth.

It’s like the brain keeps talking in a language the muscles can no longer understand.  

If you or your loved one has ALS, this is when they need help dressing and showering. 

Others may notice one arm losing strength. 

The sad truth is… 4 out of 5 people with ALS are likely to suffer asymmetric limb weakness. [1]

One side of the body works. The other side grows frail and atrophies.And while scientists have yet to figure a clear-cut treatment… 

Here’s a Ray of Sunshine in a Dark Sky

In this special report, I’m going to show you a breakthrough protocol… that uses nutrients found naturally in the body… to help 7 out of every 10 people who try it. [8]

That’s not all…

…while you’d expect everybody to respond differently, more than half the people who follow this methodology report elevated energy levels and…73% report a reduction in muscle tremors. [8]

Uses nutrients found naturally in the body to supports energy levels and soothe away muscle weakness.

What makes this protocol work is, it takes a different approach:

Instead of focusing on the symptoms, it helps brain nerves survive the ALS toxic tsunami wave.

What’s the toxic tsunami wave?

Well, scientists have long known this is one of the first red flags that… flips the environment of surrounding brain nerves to go from livable to a living hell.

Case in point, it only takes 24 hours for this destructive cocktail to start deteriorating brain neurons. [6]

And this is important because, the deterioration (and death) of these neurons is the reason why ALS patients start feeling their muscles weaken and ultimately become paralyzed.

What Spanish Scientists Discovered While Saving Neurons of Stroke Survivors That May Help Those With ALS

A few years ago, a team of Spanish scientists set out to figure the best way to save the most brain nerves after someone had a stroke. [6]

This is especially challenging because, the worst hit area (the core zone) suffers an extreme drop in blood flow. As you’d expect, this leaves brain nerves without oxygen and glucose. 

In short, leaving brain nerves with no way to produce energy. 

The longer this goes on, the more brain neurons perish.

No energy, no life. Remember that.

The Spanish scientists witnessed another phenomenon that accelerates the death of neurons.

  • In a healthy brain, glutamate is a friend. This essential amino acid helps neurons talk to each other. It also helps us with memory and learning. 
  • When someone suffers a stroke, glutamate is a foe. It’s bad news because glutamate levels in the brain spike to 10 times normal levels, contributing to the deterioration of the brain… [6]

Triggering a Toxic Tsunami That Kills Brain Neurons

The rising glutamate is like an accelerating tidal wave:

Glutamate shoots up to levels the body can’t handle.

As you already know, this pushes motor neurons to deteriorate and die.

As these cells die, they burst, releasing more glutamate into the system.

This in turn, elevates glutamate levels even higher, affecting more neighboring cells.

You can probably guess what happens to those neighboring cells? They too die and burst, releasing more glutamate.

And so on and so on until the body is flooded with toxic levels of glutamate. It’s a vicious downward spiral.

When neurons die they burst releasing more glutamate into the system.

When there is a flood of glutamate in our brains, it’s almost as if the wiring stops connecting with the rest of the body, like in our light switch example.  

Just like with stroke victims, we believe the same phenomenon of unplugging the brain communicator cells from the rest of the body is at play when it comes to ALS.

So What Can You Do About It?

Many people suffer needlessly because they don’t know their options.

For example, you might think that the most effective approach is pressing the brakes on that glutamate ‘toxic tsunami.’

Afterall, that’s the approach used by one of the more popular solutions for ALS [1].

What kind of relief does it offer?

Only a median increased survival time of about two to three months.

What’s more, England’s National Health Service reports that patients who use it… ‘feel no different day-to-day.’ [10]

And while we always recommend consulting your physician on what would help you the most, we suspect you’re here for a reason…

…you want to leave no stone unturned because:

While we don’t know how many tomorrows we’ll have… 

We Can’t Sit and Watch as Our Loved Ones Fade Away

That’s why, back in 2014, we decided to take a different approach to helping ALS patients live a better life.

Remember how the Spanish scientists discovered one reason that triggers neurons to perish is… they are left with no way to produce energy?

No energy. No life.

So, what’s the battery that energizes our cells?

It’s the mitochondria. When you build up the strength of this powerhouse, it can withstand the onslaught of glutamate.

So, instead of trying to stop the glutamate ‘toxic tsunami’ wave by changing the cell’s environment (as other popular solutions do), we’re arming neurons to survive that brutal toxic wave war.

The result is Simplesa’s AAKG+ core protocol blend.

AAKG+ is an advanced, four-in-one nutritional solution that’s purposely designed to help alter the course of ALS.

And it does this by fueling the cellular energy cycle. This, in turn, kicks the mitochondria’s ‘energy production capacity’ into high gear.

New energy. New life.

This novel approach focuses on arming the mitochondria so it can withstand the onslaught of toxic glutamate.

With consistent use, Simplesa’s AAKG+ helps ease muscle twitching, relieve body weakness and support elevated energy levels.

And while everyone responds differently, it’s not uncommon to hear comments like this one from Jennifer:

“It gives me the energy to stay up all day, like from 7 am to midnight.”

In a moment, you’ll get to hear 100 more reviews to help you decide if AAKG+ is right for you or your loved one. 

First, let’s cover the 4 potent ingredients that make AAKG+ work. 

The 4 neuro-nutrients are meticulously sourced and scientifically formulated right here in the USA… to ensure the highest absorption rates and uncompromising quality.

It starts with…

#1) The Key to Replenishing Our Cellular Battery

Alpha-Ketoglutarate (AKG) is a natural substance that’s concentrated in the cell’s mitochondria (the battery that energizes our cells) and the liquid gel which fills our cells. 

AKG isn’t just a potent antioxidant, that also increases collagen production [11], it also plays a much bigger role:

It regulates the speed of cellular energy production.

Case in point, draining the levels of AKG in our cells is like pressing the breaks on the cell’s ability to produce energy.

And this happens because AKG works as an ‘energy donor’ in the Krebs cycle.

You may remember the Krebs cycle from science or biology class. Without getting too technical, the Krebs cycle is an 8-step chain reaction happening inside our mitochondria. 

End result? Energy that powers all living cells.

Here’s where it gets interesting…

Scientists have long known that the cell’s energy production rate is linked to how fast we age. The lower our cellular energy is, the faster we age. [19]

So, researchers at the Buck Institute wanted to figure the impact of consuming AKG. [12, 13] 

Could it put the usual signs of cell aging on time-out?

In the study, researchers divided 182 aging mice (55 years in human years) into two groups. Only one group of mice was fed a diet containing AKG. 

Then, every 8 weeks the researchers would measure for signs of vitality and zest for life (such as eye health, tremors, grip strength, and curving of the spine among other signs of aging). This went on for 21 months, or for as long as mice were alive.

The result: the group that consumed AKG saw a 40% boost in healthspan.

What’s healthspan? 

It’s not merely surviving as the years go by. It’s enjoying blissful days, free of the usual alignments and disabilities that come with age.

Walking, breathing, living and having a zest for life. 

For those reasons, AKG is the key superstar ingredient we’ve included in Simplesa’s AAKG+. 

It also includes…

#2) COQ10 to Shield Against Neuron Damage

You may have heard of CoQ10 and how it’s among nature’s most powerful antioxidants.

But did you know it’s more effective than vitamin E when it comes to protecting against cell neuron damage. [14]

And, neuron damage is one of the main reasons the brain communicator cells lose their ability to talk to the rest of the body. 

In fact, studies show that CoQ10 might play a bigger role than we once thought when it comes to… helping turn around nerve damage (like ALS). [15] [16]

CoQ10 more effective than vitamin E when it comes to protecting against cell neuron damage.

But that’s only part of the CoQ10 story.

It’s no coincidence that CoQ10 lives in the cell’s mitochondria (our energy powerhouse). 

You see, CoQ10 isn’t just essential for helping the body patch up repair damaged cells, it’s also the spark your cells need to generate energy.

Just like AKG, it plays a crucial role in amplifying the cell’s energy production rate (the Krebs cycle).

Are you starting to see how CoQ10 plays two critical roles when it comes to ALS?

  • On one level, it helps protect the mitochondria from damage (the potent antioxidant effect). 
  • While, at the same time, it boosts the mitochondria’s ability to produce energy. Energy it needs to survive the glutamate ‘toxic tsunami.’

For those reasons, we’ve included the most bioavailable form of CoQ10 in Simplesa’s AAKG+. But that’s not all, AAKG+ has one more ingredient that…

#3) Helps Squash The Toxic Tidal Wave

GABA (Gamma Aminobutyric Acid) is a chemical messenger in the brain. It has a calming effect. 

Our body needs this to make it through stress and anxiety – without crushing our nervous system. 

Simply put, it shields our nerve cells from being over-stimulated (stressed out).

Why is this important when it comes to ALS?

In healthy adults there’s a balance between GABA and glutamate. 

The first calms our nerves, the second excites them. It’s like an on and off switch.

But what happens if the switch is always on?

Like a morning alarm clock that buzzes forever. No rest. 

We suspect that’s what’s happening to the brain cells of someone with ALS. In fact, studies show that GABA levels diminish and dip as glutamate levels spike. [17] 

Sounds familiar? This is the glutamate ‘toxic tsunami’ wave pushing neurons to the edge of existence. 

There’s two more reasons for including GABA in AAKG+. 

  • Firstly, we want to replenish the body’s GABA stores – because low levels of GABA contribute to muscle spasticity and stiffness.
  • And, secondly, GABA pushes back on the excessive glutamate levels… giving neurons a fighting chance against the toxic tidal wave. 

Knowing that, we did extensive research to identify the most effective approach to…

#4) Help Brain Neurons Survive and Regrow

Niacin is a water-soluble B vitamin. Once in the body, it’s converted into the second most important coenzyme in the body; NAD (nicotinamide adenine dinucleotide).

Why is it so important?

Because it’s one of only a few coenzymes that directly impact the body’s ability to create and utilize energy.

In fact, supplementing with NAD has been shown to bump up the mitochondria’s ‘energy production capacity.’ [18]

What’s more, mental agility is often a sign of sufficient NAD levels in nerve cells.  Why? Because it plays a key role in brain neuron development and survival.

Naturally, scientists wanted to put this to the test in the most extreme of conditions; stroke survivors.

The cell’s inability to regrow axons (wire like structures) hampers the ability to move and feel limbs.

You see, one of reasons a stroke (or spinal cord injury) cripples the person’s ability to move, or even feel their limbs is… the cell’s inability to regrow axons. [21]

What are axons? Simply put, it’s the thin ‘wire like’ structure of the neuron that helps it communicate with other neurons. 

So, here’s what scientists at Oakland University did: 

They simulated a stroke in lab rats by blocking blood flow to the brain for two hours. Then, they separated the rats into two groups. One group was fed a daily dose of niacin for 14 days. [20]

Scientists were amazed by the results: niacin plays a major role in supporting the nerve’s regeneration process (neurite outgrowth). 

Can you see how this is relevant to ALS?

Case in point, scientists believe this nerve regeneration (neurite outgrowth) process is a critical factor in restoring neuron function after it’s damaged. [22] 

By now, you can probably see why we’ve included Alpha-Ketoglutarate (AKG), GABA, Ubiquinol (CoQ10) and Niacin in Simplesa’s AAKG+ Core Powder.The 4 neuro-nutrients in AAKG+ aren’t just 100% natural, they’re also…

The Purest Form, Potent Compounds to Ensure the Highest Bioavailability and Purity

What this means is… we’ve gone to extreme lengths to source these 4 neuro-nutrients are in the purest, freshest and most effective form.

The same raw form supported by scientific research. (You can see the certificates of analysis right here.)

No fillers. No cutting corners because our client’s wellbeing depends on it. 

It’s been our pledge since starting back in 2014; quality first.

That’s why, Simplesa’s AAKG+ is scientifically formulated and manufactured in the USA in an FDA inspected facility.

What’s more, the 4 neuro-nutrients in AAKG+ aren’t just designed to work in synergy… where the combined effect is far greater than taking each nutrient on its own…  Simplesa’s AAKG+ is purposely designed to…

  • Soothe away muscle discomfort and weakness. Instead of watching muscles waste away this helps your body get stronger.
  • Increase mitochondrial energy output to help give you the energy you need to live life.
  • Reduce anxious feelings and negative moods (start feeling like your normal self again).
  • Sooth away muscle fatigue, leg cramps and muscle twitching that makes holding a cup of coffee near impossible.
  • The most bioavailable form of CoQ10 (Ubiquinol) helps give further protection against cell neuron damage.

Thousands of men and women swear it helps slow down progression and improve their quality of life. And now, you can too.

How Much of a Difference Can AAKG+ Make?

Just ask Scot , Sarah, Ronnie and others…

And while I can’t promise a magic carpet ride (because everybody’s different), here’s how it’s been changing lives since 2014:

Real results from real ALS patients since 2014 (there are 100s more reviews to see here.

If you’ve read this far, I think you can see why…

You Too Can Benefit From AAKG+

We also made sure it’s not another stack of ‘hard to swallow’ pills. 

Instead. it’s super simple to use:

  1. Simply add 1 leveled scoop to any beverage or food with a consistency that permits easy mixing. 
  2. Stir until thoroughly mixed. (It tastes good and mixes well and easily with a shaker bottle.)
  3. Take three times daily or as directed by your health care practitioner.

As you’d expect, Simplesa’s AAKG+ has clearly spelled out ingredients (no mystery blend that leaves you wondering what’s in the mix):

Now, it’s perfectly normal to realize that… the only way to help you decide if AAKG+ is right for you or your loved one, is getting it into your hands (so you can start using it and noticing the difference it makes).

For that reason, we’ve done 3 things:

Firstly, you pay zero for shipping and handling.

Since AAKG+ isn’t available in health food stores, we’re eating the cost of shipping to get it into your hands as soon as possible (and let it start working for you or your loved one right away). 

Secondly, you risk nothing by trying AAKG+ today.

All we ask is that you use it for 30 days. If, at any point in the next 90 days, you’re not satisfied with for any reason (or no reason at all), then return the empty bottles for a full, courteous refund.

Thirdly, because the results have been so positive, we’re trying to get it into the hands of more people who need relief now.

That’s why, for a limited time, you can take advantage of this exclusive offer…

Try AAKG+ Risk-Free at the Lowest Price and Get a Free Gift

If you tried to purchase just 2 of the 4 neuro-nutrients in AAKG+ at your local health food store… getting a 30-day supply of CoQ10 (Ubiquinol) and high-dose  AKG… you could easily spend up to $318.5.

And you’d have no guarantee you’d get these neuro-nutrients in the most effective pure form compounds to ensure the highest bioavailability. 

But thanks to this special offer, you can get all 4 neuro-nutrients in one convenient, easy to use solution (instead of having to mix and match what might be ‘hard to swallow’ pills)… for as little as $4.99 per day.

That could save you as much as $168.51 per month.

Here’s the best part, if you decide to go for the 60-day supply today…

You’ll Get 2 Free AAKG Powder Tubs (Worth $51.98)

Here’s why this is the perfect companion to Simplesa’s AAKG+… 

As you already know, we’ve included Arginine Alpha-Ketoglutarate (AAKG), GABA, Ubiquinol (CoQ10) and Niacin in Simplesa’s AAKG+ Core Powder. 

3 of the neuro-nutrients (GABA, CoQ10 and Niacin) are in full dosages. The fourth neuro-nutrients (AAKG) is set at the minimum recommended dosage of 9 grams a day. 

Why is that important?

To allow you to increase your increase AAKG dosage up to the recommended 18 grams per day at your own pace (without having to increase GABA, CoQ10 and Niacin at the same time).

That’s where Simplesa’s AAKG Powder comes in.

  • It’s the same high-potency, pure form amino acid in AAKG+
  • Simplesa’s protocol calls for 3 main servings of AAKG+ per day and…
  • Smaller doses of AAKG throughout the day. 
  • This is intended to support energy production through the day

Normally, you’d have to buy AAKG separately. However, on this page only… you get two complementary AAKG tubs with your 60-day supply. Take advantage of this generous offer today because it won’t be available forever.

Choose Your Package

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.

[1] https://www.simplesanutrition.com/content/pdf/DP-White-Paper.pdf 

[2] https://www.simplesanutrition.com/blog/simplesa-aakg-core-powder-nutrients-support-parkinsons-disease/ 

[3] https://www.pharmaceutical-technology.com/analysis/history-of-als/ 

[4] https://als.ca/blogs/dr-richard-bedlacks-quest-als-discovery-truth/ 

[5] https://journals.sagepub.com/doi/10.1177/0271678X15606721 

References

[1] Deanna Protocol Program for ALS: Substantiation and Putative Mechanisms. 2016.

[2] “ALS Incidence and Prevalence Worldwide.” Alstreatment.com, alstreatment.com/amyotrophic-lateral-sclerosis-incidence/.

[3] “Unmet Needs: A Brief History of ALS and Its Sparse Pipeline.” Pharmaceutical Technology, 10 Sept. 2021, www.pharmaceutical-technology.com/analysis/history-of-als/.

[4] Morris, Tom. “Dr. Richard Bedlack’s Quest for ALS Discovery: The Truth Is out There.” ALS Society of Canada, 27 July 2017, als.ca/blogs/dr-richard-bedlacks-quest-als-discovery-truth/. Accessed 3 Jan. 2023.
 
[5] Castillo, José, et al. “A Novel Mechanism of Neuroprotection: Blood Glutamate Grabber.” Journal of Cerebral Blood Flow & Metabolism, vol. 36, no. 2, 2 Oct. 2015, pp. 292–301, 10.1177/0271678×15606721. Accessed 2 Dec. 2022.

[6] “A Novel Mechanism of Neuroprotection: Blood Glutamate Grabber.” Journal of Cerebral Blood Flow & Metabolism, vol. 36, no. 2, 2 Oct. 2015, pp. 292–301, 10.1177/0271678×15606721. Accessed 2 Dec. 2022.

[7] “Should I Take Riluzole? – Oxford MND Centre.” Www.ouh.nhs.uk, www.ouh.nhs.uk/services/departments/neurosciences/neurology/mnd/support/riluzole.aspx.

[8] “Neuro-Health Protocol : Simplesa : ALS.” Www.simplesanutrition.com, www.simplesanutrition.com/neuro-health/. Accessed 3 Jan. 2023.

[9] Asadi Shahmirzadi, Azar, et al. “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.” Cell Metabolism, vol. 32, no. 3, Sept. 2020, pp. 447-456.e6, www.ncbi.nlm.nih.gov/pmc/articles/PMC8508957/, 10.1016/j.cmet.2020.08.004. Accessed 3 Jan. 2023.

[10] “Should I Take Riluzole? – Oxford MND Centre.” Www.ouh.nhs.uk, www.ouh.nhs.uk/services/departments/neurosciences/neurology/mnd/support/riluzole.aspx.

[11] Son, Eui Dong, et al. “Alpha-Ketoglutarate Stimulates Procollagen Production in Cultured Human Dermal Fibroblasts, and Decreases UVB-Induced Wrinkle Formation Following Topical Application on the Dorsal Skin of Hairless Mice.” Biological and Pharmaceutical Bulletin, vol. 30, no. 8, 2007, pp. 1395–1399, 10.1248/bpb.30.1395. Accessed 1 Oct. 2021.

[12] “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.” Cell Metabolism, vol. 32, no. 3, Sept. 2020, pp. 447-456.e6, www.ncbi.nlm.nih.gov/pmc/articles/PMC8508957/, 10.1016/j.cmet.2020.08.004. 

[13] “Buck Institute Study: Bodybuilding Supplement Might Boost Health.” The Mercury News, 7 Sept. 2020, www.mercurynews.com/2020/09/07/buck-institute-study-bodybuilding-supplement-might-boost-health/. Accessed 3 Jan. 2023.

[14] Matthews, R. T., et al. “Coenzyme Q10 Administration Increases Brain Mitochondrial Concentrations and Exerts Neuroprotective Effects.” Proceedings of the National Academy of Sciences, vol. 95, no. 15, 21 July 1998, pp. 8892–8897, 10.1073/pnas.95.15.8892. Accessed 25 Aug. 2021.

[15] Shults, Clifford W., et al. “A Possible Role of Coenzyme Q10in the Etiology and Treatment of Parkinson’s Disease.” BioFactors, vol. 9, no. 2-4, 1999, pp. 267–272, 10.1002/biof.5520090223. Accessed 3 Jan. 2023.

[16] “A Possible Role of Coenzyme Q10in the Etiology and Treatment of Parkinson’s Disease.” BioFactors, vol. 9, no. 2-4, 1999, pp. 267–272, 10.1002/biof.5520090223. Accessed 3 Jan. 2023.

[17] “Brain Imaging Suggests Neurotransmitter Imbalance in ALS | ALZFORUM.” Www.alzforum.org, www.alzforum.org/news/research-news/brain-imaging-suggests-neurotransmitter-imbalance-als. Accessed 3 Jan. 2023.

[18] Jia, Haiqun, et al. “High Doses of Nicotinamide Prevent Oxidative Mitochondrial Dysfunction in a Cellular Model and Improve Motor Deficit in a Drosophila Model of Parkinson’s Disease.” Journal of Neuroscience Research, vol. 86, no. 9, 1 July 2008, pp. 2083–2090, pubmed.ncbi.nlm.nih.gov/18381761/, 10.1002/jnr.21650. Accessed 3 Jan. 2023.

[19] Sun, Nuo, et al. “The Mitochondrial Basis of Aging.” Molecular Cell, vol. 61, no. 5, Mar. 2016, pp. 654–666, 10.1016/j.molcel.2016.01.028.

[20] Cui, Xu, et al. “Niacin Treatment of Stroke Increases Synaptic Plasticity and Axon Growth in Rats.” Stroke, vol. 41, no. 9, Sept. 2010, pp. 2044–2049, 10.1161/strokeaha.110.589333. Accessed 21 May 2022.

[21] Walmsley AR, Mir AK. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. Curr Pharm Des. 2007; 13: 2470–2484.CrossrefMedlineGoogle Scholar

[22] “Neurite Outgrowth.” QPS Neuropharmacology, qpsneuro.com/in-vitro-services/neuronal-plasticity/neurite-outgrowth/. Accessed 3 Jan. 2023. 

Co-Therapies and Nutritional Supplements for Parkinson’s Disease

ALS, Deanna Protocol, Nutrition, Parkinson's, simplesa, Supplements
vitamins for parkinson's

This year alone, 50,000 Americans will be diagnosed with Parkinson’s disease (PD). The number of cases in the US suffering with PD will be close to 1.0 million patients by 2020. This neurological disorder is second in total number of patients only to Alzheimer’s disease. What’s concerning our physicians the most is that the number of cases seems to be increasing. A report from the Mayo Clinic in March 2019, showed that the incidence of PD has increased significantly in the 30 years between 1976 to 2005 (1).

Neurologists serve in the front lines of the fight against PD, ALS (Amyotrophic Lateral Sclerosis) and Alzheimer’s. Their work load is increasing and sadly, the number of qualified neurologists available to take care of us is not keeping up with the increasing number of cases of these diseases.

The reality of Parkinson’s disease is upon us and the trend tells the full story. We can do nothing… or we can begin to take action now. If you fall into the latter group (and we hope that you do) we’ve got some good news.

Patient education and self-help efforts are increasing. New treatments and local support groups are emerging that help disseminate valuable information to help fight PD. Taking responsibility for your health is THE smartest strategy. Expecting that our health care system will be there for us and take care of us during a chronic disease is not a bet one should take. Take responsibility for your PD.

In the event that you’ve been diagnosed or are currently suffering with PD, what do you do now? Here’re some therapies and co-therapies that will help you fight PD.

  1. Make sure that you’re being treated by your Doctor or Neurologist

     

    Step one is to make sure that you get yourself the best professional care you can get. You can find a neurologist near you on WebMD.

  2. L-dopa (Levodopa) Supplementation for PD

     

    This is the go to drug for PD. It helps increase dopamine levels that cause many of the symptoms associated with PD. Although it’s not a cure, it helps keep symptoms under control during the early stages. Remember that L-dopa cannot reduce every PD symptom. Talk to your physician about this therapy.

  3. Nutritional Supplements for Parkinson’s Disease

     

    The Parkinson’s Foundation lists certain Nutritional Supplements, such as anti-oxidants and vitamins, as possible Over the Counter (OTC) and Complementary Therapies (4). These nutritional supplements for Parkinson’s disease show improvements in the reduction of certain symptoms of the disease. Among the more promising natural remedies for PD are:

    1. Coenzyme Q10 (CoQ10): also known as Ubiquinone, seems to play an important role in Mitochondrial health, the power center of our cells. A more concentrated form of Ubiquinone is Ubiquinol. This powerful neural booster is present in the AAKG+ product from Simplesa Nutrition. This supplement is most helpful in reducing tremors and muscle rigidity.
    2. Vitamins E and C: can fight damage in the brain and neurons caused by free radicals and may even lower the risk of getting PD in the first place. These vitamins are most helpful in reducing damage to your neurons.
    3. Glutathione: is known as one of the most powerful antioxidants available. A better absorbing form of Glutathione is called Liposomal Glutathione. Few supplements have received the level of positive comments from the scientific community that Glutathione has received. This supplement is most helpful in reducing oxidative damage to your organs and nervous system.
    4. Vitamin B-12: also known as Methylcobalamine is an important vitamin in nerve and brain health and may have a significant effect in protecting our memory. Vegetarians often have an acute Vitamin B-12 deficiency. Look for sublingual Liposomal B-12 for best absorption. This supplement is most helpful in helping your higher brain functions and in protecting your memory.
    5. Multi-Vitamin supplements: The National Institutes of Health (NIH) has put together a list of recommended nutritional supplements for Parkinson’s for daily use. Most of these vitamins and minerals and in the appropriate dosages for healthy adults are available in Total Health AM. This multi-vitamin and multi-mineral is most helpful in providing the necessary building blocks for a healthy body to help fight disease and repair damage.
  4. Diet and Exercise

     

    We know we keep hearing about it but Diet (Mediterranean Diet) and Exercise keeps the body healthy, your immune system robust and your renal and endocrine (detoxing) systems humming along. Stay with this winning strategy!

  5. Embrace a Spiritual Life

     

    If you’re religious, great! If you’re more of a free spirit, that’s ok too. At the very least spend time on the inside. Meditate, pray, breathe deeply, be mindful and be thankful. These simple co-therapies will help you cope with your PD and with the everyday challenges of life. As someone once said, “Life is not measured by the number of breaths we take, but by the moments that take our breath away…”.

So there you have it. PD will probably change your life but it’s not necessarily a death sentence. If you take responsibility for your PD, the progression will be slower, you will be in control, live a quality life and you will most likely increase the number of moments… that take your breath away.

Stay Strong!

Source:
1. Thelen, Gil. “A Parkinson’s ‘pandemic’ is coming and there aren’t enough doctors to deal with it.”, THE MIAMI HERALD, March 25th, 2019.
2. Parkinson’s Foundation, “New Study Shows 1.2 Million People in the United States Estimated to be Living with Parkinson’s Disease by 2030”, PARKINSON.ORG, July 10th 2018.
3. Mayo Clinic. “Parkinson’s disease”, MAYOCLINIC.ORG.
4. Parkinson’s Foundation, “Over the Counter and Complementary Therapies”, PARKINSON.ORG

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

Energy Expenditure in Nerve Cells continues to be a Trigger for ALS

ALS, Blog, Supplements, ,

blue neurons als treatment

Finding a cure for ALS continues to be a difficult and elusive endeavor. This is understandable since the body is a complex system. Moreover, the degree of difficulty of finding a cure goes up exponentially, when one talks about the body’s nervous system. Nevertheless, advances and findings are coming to light rather quickly and we may be one piece of the puzzle away from a major breakthrough.

One cannot help but notice that within these new findings, certain similar themes that trigger ALS keep coming up. One such theme is the damage caused by the increase in energy expenditure by the nerve cells. A recent study called “Consideration of gravity as a possible etiological factor in Amyotrophic Lateral Sclerosis” that appeared in the journal Medical Hypotheses, suggests that nerve fibers that are disposed vertically (essentially oriented vertically) can accumulate too much cell waste. This cell waste accumulation can lead to damage to the nerve cell and even to cell death. The findings suggest that the uneven distribution of nerve cell loss in PALS, can have something to do with the fact that vertically oriented nerve cell bodies (axons) consume about 2% more energy than transverse running axons.

This may not seem like much but over a period of months and years this 2% excessive energy consumption, due to gravity, may cause the accumulation of waste in vertically running axons. This can deteriorate and weaken nerve cells and can lead to the onset of ALS. Other factors such as using your right hand more frequently (if you’re right handed), or excessive exercising, or your diet, or even your emotional wellbeing can all affect the progress of ALS.

Ok, so how do I counter the effects of excessive energy expenditure? I can’t stop my nerve cells from using energy! There’re a few strategies that we can recommend:

  1.  Avoid repetitive movements and try to change your body’s orientation throughout the day. There’s a recurring link between the deterioration of the nerve cells we use most and ALS. Making small adjustments throughout the day may help reduce the energy expenditure of the same nerve cells.
  2. Increase your intake of supplements that help your nerve cells produce energy. We recommend that you look at Simplesa AAKG+ or learn more about the Deanna Protocol.
  3. Increase the intake of supplements for ALS that help eliminate cell waste (such as excess Glutamate) and that help reduce oxidative damage. Try Oxaloacetate from Natural Dynamix Endure DX. Also try Liposomal Glutathione one of the most powerful anti-oxidants available.
  4. Engage in Moderate intensity exercise that is non-exhaustive and specifically designed for patients with ALS. Learn more here Exercise Program for ALS,
  5.  Do what you can to reduce stress and stay in reasonably good emotional balance. There are many natural remedies for ALS. Reduce coffee intake, practice Yoga and meditation, and develop a deeper spiritual life. You can also try natural Hemp Oil remedies. Proponents of Hemp Oil suggest that it may help with feelings of nervousness, anxiety, improved sleep and reduced pain.

The discoveries will continue to come. Each new finding will help our scientists complete this elusive puzzle and get us one step closer to a solution. The cure is out there. In the meantime, we can do what we can to reduce the rate of damage to our nerve cells. We can improve our exercise routine, our supplement intake, and our spiritual world. Choose to live your best life. Stay strong!

Source:
Pena, PhD., Ana. “Energy Demands to Counter Gravity in Vertical Neurons May Lie at Origin of ALS”, ALS NEWS TODAY, August 30th, 2019.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

The Benefits of Moderate-Intensity Exercise now Easier to Achieve than Ever for Patients with ALS (PALS)!

ALS, Blog, ,

als exercise program

It’s been a controversial subject for years. Can exercise help or could it possibly hurt patients with ALS?

In a 2016 study, a group of patients suffering from ALS was evaluated on a structured home-based program. This structure home-based program, as the name implies, was conducted without the supervision of a physical therapist (Home-EX group) at home. The exercises consisted of muscle stretching, muscle training, and functional training for 6 months. At the end of the 6 months, the patients were evaluated by physical therapists based on ALSFRS-R (ALS Functional Rating Scale–Revised) scores. The Home-EX group was found to have a significantly higher respiratory function sub-score as well as a higher total score on the ALSFRS-R, when compared to the control group.(4)

These promising results and the findings of other similar studies have shown the importance of moderate-intensity exercise as a therapy to help prevent muscle weakness. Along with strengthening muscles, the studies found a variety of other benefits.

Benefits of Moderate-Intensity Exercise for Persons with ALS (1):

  • May facilitate healthy innervation (stimulation through nerves) of neurons and synaptic networks to slow degeneration of neurons, i.e. moderate-intensity exercise may slow progression of weakness in the body.
  • May promote a neuroprotective effect on the muscles.
  • May help to maintain cardiopulmonary efficiency, muscle strength, and endurance without overstressing the muscles or neurological system.
  • Using exercises matched to physical ability may help persons with ALS maintain a high level of function and independence.
  • People with ALS who have participated in an exercise program have experienced longer maintenance of strength, respiratory capacity, and function compared to those that did not participate in an exercise program.
  • No harm from participating in moderate intensity exercise programs have been reported.

Based on these findings and other compelling studies (please see References below), Simplesa Nutrition embarked on a journey to create an exercise program that was effective, easy to follow and readily available to everyone suffering from ALS or other Neurodegenerative diseases. It was clearly evident that many PALS face real challenges when it comes to affordability and accessibility to specialized physical therapists. Therefore, delivering the expertise of a Board Certified specialist in Neurologic physical therapy along with providing basic exercise equipment became an indispensable part of a successful program.

We partnered with Julie Talkington, a Board Certified Specialist in Neurologic Physical Therapy and together we developed a structured exercise program that was tailored for all stages of ALS, specifically; Early, Middle, and Advanced stages of the disease.

The result of our collaboration is the “Exercise Program for ALS”. The Exercise Program is designed as an at-home, step-by-step exercise guide for those suffering from ALS or other similar neurodegenerative diseases. Each exercise is clearly explained and is easy to follow and include illustrations for the beginning and ending movements. Each exercise is designed to target specific muscle groups in a systematic manner to maintain mobility and avoid overuse of these muscles.

The “Exercise Program for ALS” is a carefully vetted selection of 50+ exercises and stretches designed to strengthen and increase range of motion of specific muscles and muscle groups. The full Program is comprised of a 40 page Manual that comes complete with General Guidelines, easy to follow, step-by-step instructions and illustrations for each exercise, energy Conservation Techniques and even Breathing Techniques. The Program also includes a set of 3 Exercise Rubber bands, of different resistance levels and a small Exercise Ball for hand squeezing and other exercises.

It is our firm belief that PALS can benefit from this program as it provides an additional set of tools to help fight this disease. We invite you to try the program and if you’d like, provide us with welcome feedback. Please click here to learn more.

Resources:

  1. A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis
    Andrew J Lui, Nancy N Byl JNPT Vol 33, June 2009 p68-87
  2. Physical Therapy for a Patient Through Six Stages of Amyotropic Lateral Sclerosis
    Vanina Dal Bello-Haas, Anne D Kloos, and Hiroshi Mitsumoto. Phys Ther. 1998: 78; 1312-1324
  3. Effectiveness of Home-Based Exercises Without Supervision by Physical Therapists for Patients with Early-Stage Amyotrophic Lateral Sclerosis: A Pilot Study
    Kitano, Kosuke et al.
    Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 10, 2114-2117

6 Ways to Help You Manage Your ALS Symptoms

ALS, Supplements, Uncategorized, ,

natural remedies for als

Those living with ALS experience a vast and varying degree of complications that accompany the disease. Although there have been extensive advancements with remedies, treatments, and devices, resources are limited and complex. Daily living proves difficult in even the simplest tasks. Yet, not everything must be so difficult. Here’s a list of simple and natural ways to help you with your symptoms and overall wellbeing.

  1. Eat a Nutritional Diet – The most important part of a nutritional diet for PALS is to remove toxins and eliminate the risk of damaging motor neurons by free radicals. Remove all sugars and processed foods1. Next you will need to introduce nutrient-dense and whole foods filled with antioxidants, vitamins, and minerals. Organic foods like free range chicken, grass-fed beef, healthy fats, and fruits and vegetables are examples of quality nutritional foods.
  2. Exercise – To help prevent atrophy, improve mobility, and strengthen muscles, non-exhaustive exercise has shown to be beneficial in patients with ALS. Typical exercise regiments should consist of aerobic exercise, breathing exercises, stretching, and light resistance movements. Also, for those in more advanced stages of ALS, caregiver assisted stretching is beneficial to prevent pressure point sores and contractures. Overall, exercise for ALS may slow progression of motor neuron degradation, help patients maintain a high level of function, and improve respiratory capacity3. It is advised to seek a professionally developed program designed by a licensed physical therapist.
  3. Occupational Therapy – This type of therapy provides rehabilitative care for activities required in daily living to patients recuperating from a physical or mental illness. Difficulties that occur for patients with ALS such as bathing, dressing, swallowing, and walking are fundamentally improved through programs of occupational therapy. Assisted devices, tools, and clothing, which can facilitate mobility and daily activities, are easily accessible. Studies show that people with ALS involved in multidisciplinary programs have longer life spans, due to social involvement and better mental health4.
  4. Supplements – A great way to ensure ALS patients are getting the appropriate vitamins, minerals and nutrients is through supplements for ALS. Avoiding malnutrition and ensuring an adequate dietary intake is a key factor in preventing atrophy, infection, and a weakened immune system5. Antioxidants and detoxifiers are equally important for preventing damage from oxidation and free radicals. Although there are various supplements that are recommended for patients with ALS, some of the more notable ones are Vitamin E and C, Vitamin B-complex, AAKG, GABA, Ubiquinol, Niacin, Vitamin D, CoQ10, Calcium, Magnesium, Selenium, Zinc, and fish oil1. The best supplements for ALS provide several benefits such as: energy production, detoxification, maintaining bone and muscle mass, improving cellular and mitochondrial function, and more1. You can find many of these supplements at simplesanutrition.com.
  5. Emotional Support – The burdens of ALS do not only affect the body, but places a heavy toll on mental and emotional health. The stress of coping with a debilitating disease is difficult to manage. Support from family and caregivers is essential to emotional well-being. For help with managing stress, depression or anxiety it can be very helpful to work with a therapist trained in cognitive behavioral therapy, which emphasizes the importance of underlying thoughts in determining how we feel and act6. There are also various support groups and forums where you can speak to others in similar circumstances.
  6. Sleep and Rest – One of the various struggles in managing ALS is constant exhaustion compounded by the inability to get restful sleep. The lack of sleep can cause another layer of complications to add to the already difficult effects of ALS. To prevent this restless cycle, there are some tips to help you secure better sleep. Some of these activities are: being active during the day, aromatherapy, eating foods that increase serotonin and melatonin, taking magnesium, adhering to a sleep schedule, drinking tea, taking a warm bath, exercise, meditation, reading, and taking soothing natural herbs. Other remedies for trouble sleeping due to pain include muscle rubs using lavender and peppermint oils, massage therapy and acupuncture, Epsom salt baths, and foam roller exercises, with the approval of a physical therapist. New remedies such as Hemp-Oil show promise in soothing and calming patients and getting them in a more restful mindset.

This is not an all-encompassing or complex list of suggestions for help with your ALS systems, but rather a simplified and natural way to tweak your daily routine. Make changes and introduce new habits at a rate that is comfortable for you. These tips can be implemented easily and may have significant improvements on living with ALS. Stay strong!

References:

  1. Levy, Jillian. “Lou Gehrig’s Disease (+ 6 Ways to Help Manage ALS Symptoms).” Dr. Axe Food is Medicine, 1 Feb. 2018, https://draxe.com/lou-gehrigs-disease/.
  2. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.
  3. Andrew J Lui, Nancy N Byl. A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis. JNPT Vol 33, June 2009 p68-87.
  4. Arbesman, Marian; Sheard, Kendra. “Systematic Review of the Effectiveness of Occupational Therapy–Related Interventions for People With Amyotrophic Lateral Sclerosis.” AJOT, Jan. 2014, https://ajot.aota.org/article.aspx?articleid=1863110/.
  5. Rosenfeld, Jeffrey, and Amy Ellis. “Nutrition and Dietary Supplements in Motor Neuron Disease.” Physical medicine and rehabilitation clinics of North America 19.3 (2008): 573–x. PMC. Web. 4 Oct. 2018.
  6. Levy, Jillian. Cognitive Behavioral Therapy Benefits & Techniques. Dr. Axe Food is Medicine, 30 Apr. 2018, https://draxe.com/cognitive-behavioral-therapy/.

The Nutritional Supplement approach to ALS!

ALS, Blog, ,

A natural and cost-effective alternative.

supplements for als

It is widely understood by the ALS community that there are limited solutions for the treatment of this devastating disease. The widely varying progression from patient to patient makes it difficult to standardize the appropriate approach. Not enough information is known and not enough research has been done. Pharmaceutical drugs are costly, cumbersome, and the benefits are often marginal.

An alternative approach to pharmaceuticals (or even an additional approach to pharmaceuticals), is to ensure that the body has the essential supplements for ALS and nutrients that it needs to help protect against the progress of this disease and to also provide much needed energy to the cells. Often, the worst case scenario with supplementation is that nothing perceivable happens, or that there are very mild side-effects from taking these supplements, many of which already occur naturally in the body. The best case scenario, however, can be delayed disease progression, reduced severity of the symptoms, and an overall improved quality of life.

The Deanna Protocol (DP), created by Dr. Vincent Tedone, is one such approach. This Protocol was initially based on Dr. Tedone’s research with his daughter, Deanna, who was diagnosed with ALS nearly 10 years ago. According to Dr. Tedone, the DP works because it provides two primary mechanisms of action. The first, is that it provides the body with the nutritional supplementation it needs and that allows the body to properly metabolize and remove excess glutamate, the leading cause of nerve cell death. The second mechanism, is that the DP provides nerve cells (neurons) with additional energy that help keep the neurons healthy and functioning for longer.

The Deanna Protocol consists primarily of the following naturally occurring supplements:

AAKG and AKG (Arganine Alpha Ketoglutarate)
AKG is the key supplement providing energy to the cells and is required by the body to keep cells alive. The Arganine in AAKG improves the palate of the AKG and makes it easier on the stomach. Arganine also produces the free radical, nitrous oxide (NO). The NO can increase blood flow, which possibly assists in the removal of excess glutamate in the blood stream. Excess glutamate is the cause of cellular death in ALS. Those with preexisting heart conditions should consult with their physician before consuming arginine.

Ubiquinol (CoQ10) helps the energy cycle in mitochondria and is known for its antioxidant properties. Oxidative stress and mitochondrial dysfunction have been implicated in the pathophysiology of ALS. CoQ10 also promotes energy and overall vitality and helps normalize circulation.

Niacin and 5-hydroxytryptophane are precursors to NADH, which is unable to be absorbed by the GI system. NADH is essential in several of the reactions of the energy cycle and is also important in transporting electrons.

GABA is an inhibitory neurotransmitter. In patients with ALS, excitatory and inhibitory neurotransmitters are out of balance, which necessitates the addition of GABA. This balance of neurotransmitters reduces anxiety and rigidity of the muscles.

Glutathione is critically important for detoxification. With its anti-inflammatory properties, it’s considered one of the most important antioxidants in the healthy functioning of cells. The body uses glutathione to protect against toxins. Cells deficient in glutathione have difficulty defending against toxins in food, pollution, radiation, carcinogens, heavy metals, and drugs.

These supplements for ALS, when combined in the appropriate doses and quantities as provided by Simplesa Nutrition, can detox the body and may improve mobility, reduce pain, increase energy, and a plethora of other health benefits. It’s often up to you, the patient with ALS, in association with your doctor, to determine the best treatment protocol or combination of protocols that works best for you. Consider nutritional supplements as an additional support in your fight against neurodegenerative diseases.

Sources:
1.    Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.
2.    ALS News Today: To ‘B’ or Not to ‘B’?. July 25, 2018 by Rick Jobus
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

Medication for Muscle Twitching, Spasticity and Fasciculation Received a Setback

ALS, Blog

Phase 2 Trial of FLX-787 has stopped, but there is still hope for those suffering from muscle cramps!

About a year ago, the U.S. Food and Drug Administration granted fast track status to Flex Pharma’s treatment for severe muscle cramps in ALS, FLX-787. Flex Pharma has just announced the cease of research and clinical trials of FLX-787.

The Phase 2 trial in the US was evaluating the effectiveness of FLX-787 administered at 30mg three times a day in comparison to placebo. The desired result is an overall reduction in muscle cramps.

Although there were some promising results, there were tolerability issues with the formulation and dosage. Now Flex Pharma is restructuring to lower costs and cutting its workforce by nearly 60 percent. The future is on hold and uncertain with FLX-787.

Other solutions exist. There is still hope to diminish or eliminate some of the musculature symptoms that accompany ALS. The Deanna Protocol by Dr. Vincent Tedone has demonstrated numerous cases of anecdotal evidence that decreases the overall symptoms of spasticity and fasciculation. Not only does it help motor neurons function properly, but has shown promising results in helping the body delay the advancement of the disease by reducing cell death.

In addition, existing ALS clients adhering to the Deanna Protocol, as formulated by Simplesa Nutrition, have reported very good tolerability of the supplements with little to no discomfort or side effects. It would seem that the strategy to help your body heal itself (or at least help it fight a better fight) by providing it with the necessary nutritional supplements is still a worthwhile option.

The moral of the story is to stay in the fight and seek alternative treatments. There are existing and continuously evolving solutions out there to help improve the quality of life of those suffering from ALS and other neurodegenerative diseases.

Sources:
1. ALS News Today: Flex Pharma Stops Phase 2 Trial of FLX-787 to Ease Muscle Cramps in ALS Patients. June 15, 2018 by Jose Marques Lopes, PHD
2. ALS News Today: FLX-787, Which Treats ALS-Associated Muscle Cramps, Wins FDA Fast Track Status. July 26, 2017 by Carolina Henriques
3. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.

The Pros and Cons of the new “Right to Try” Law

ALS, Blog, Resources, , , ,

On May 30th 2018, the President signed the recently passed Right to Try (RTT) legislation into law. This new law allows patients to receive unapproved medications without FDA notification for up to one year. It also removes the FDA from prohibiting access to an experimental therapy and removes the FDA from advising on dosing, schedule, method of administration or other important safety measures. In short, you’re able to side step the FDA and go directly to the drug manufacturer. You’re basically on your own without the oversight of the FDA. So, Caveat Emptor (buyer beware) and proceed with caution.

Nevertheless, this opens up the door to new possibilities that were simply not available before.

Here’re some of the Pros and Cons as we see them.

PRO’s:

  • Finally, some options. The RTT provides a level of freedom…and hope, that would otherwise be denied patients of terminal diseases.
  • Some of the therapies may prove beneficial and/or point the investigators and drug companies in a better direction.
  • It’s the right of every individual to choose their own destiny.
  • Side stepping Governmental bureaucracy and perhaps accelerating therapies that show promise.
  • Patients can try other drugs, supplements and therapies and report their results to their physicians and drug companies. Now information can flow in more directions.
  • The ALS Association both welcomed and voiced reservations about RTT. The association is aware of and is tracking this new law and will communicate with the ALS community.
  • Since the drugs are experimental and not FDA approved, this MIGHT lower treatment costs, as pharmaceutical companies cannot make a profit on these drugs until they’re FDA approved.
  • Possible access to other treatments and drugs, available outside the US, that have shown promise in other countries.

CON’s:

  • Some medications may not be safe, although they must have passed Phase 1 of clinical trials before patients of RTT can try the drugs.
  • Patients must look out for “bad actors” stepping in now to take advantage of patients vulnerabilities. Check history and reliability of manufacturer.
  • Pharmaceutical companies have very little incentive to provide access or broadly distribute their meds since they cannot make money until the drugs are FDA approved.
  • The RTT law could weaken current patient protection laws enforced by the FDA.
  • The reality is that many experimental drugs have limited access and availability anyway.
  • The RTT law may work as a pressure release valve and may reduce pressure on the FDA to speed up approval of Phase 1, 2 and 3 drugs in the pipeline.
  • Patient has little to no legal safeguards in case therapy produces more harm than good.

All in all, we think that the net effect of the new RTT law will be a positive one. This law opens up the conversation about the FDA’s unjustifiably slow and expensive process and provides the patient with some control over their destiny. That being said, patients need to be careful not to make a bad situation worse and should continue to consult with their physicians before venturing into unexplored territories.

Sources:

Cannabinoids to Treat ALS?

ALS, Blog, Resources, Support

And OTHER Neurodegenerative Conditions

Let’s be honest, when you hear or read the word Cannabis, Hemp, CBD, Marijuana, what comes to mind? Some people giggle, others cringe, some get offended. Now, there’s an increasing group of ex-sceptics, including reputable researchers, who contemplate and study the POSSIBILITIES.

Understanding how marijuana and the brain’s own natural cannabinoid system works is helping researchers design new medicines.

Cannabinoid expert Daniele Piomelli, PhD, of the University of California in Irvine. Says, “It’s believed that the controlled therapies that come out of this research might provide select benefits to patients while avoiding some of the unwanted effects seen with the drug.”

Research from California Pacific Medical Center in San Francisco points to the promise of marijuana-like treatments for those with the fatal brain disorder ALS, also known as Lou Gehrig’s disease.

We all know new treatments for ALS are desperately needed.

ALS wreaks its havoc by harming nerve cells and patients experience progressive muscle weakness that can hinder movement, speech, even swallowing and breathing. The only FDA approved drug for ALS, Riluzole (marketed as Rilutek), extends life on average by about two months,” says Abood. “Evidence from our study suggests that a marijuana-based therapy could create a much greater effect, perhaps extending life by three years or more.”

ALSO SEE: Simplesa’s Hemp Oils (700mg + MCT, 900mg, and Full Spectrum)

In the study, ALS mouse models were given either the marijuana compound THC, the marijuana compound cannabidiol, cannabidiol plus THC, or a placebo daily following the onset of disease signs. The researchers measured disease progression by testing how long the mice could stand on a slowly rotating rod. The more severe their nerve cell degeneration, the less time the mice can balance on the rod. In addition, two conditions of ALS, the loss of movement ability and survival time, were analyzed using a mathematical model.

“We found that treatment with THC delayed disease progression by seven days and extended survival by six days in the mouse model,” says Abood. “This corresponds to three years in human terms.”

Another part of the study determined that the marijuana compounds create their benefits by reducing two molecular processes, known as oxidative stress and glutamate excitotoxicity. These processes have been implicated in ALS and are thought to harm nerve cells.

Other Neurodegenerative conditions

Another animal study also indicates that a marijuana-like compound can protect brain cells from the damage produced by the disorder Parkinson’s disease.

“For the first time, our research shows the neuroprotective value of marijuana-like compounds in a well-established animal model of Parkinson’s disease,” says study author Andrea Giuffrida, PhD, of the University of Texas Health Science Center in San Antonio.

As a next step, the researchers are testing whether the marijuana-like compounds have neuroprotective value when brain cell damage is already present and whether they can prevent the progression of brain cell loss. “Learning more about the mechanisms by which marijuana-like compounds may slow down or prevent neurodegeneration in Parkinson’s disease may translate into new pharmacological treatments that could fight this disorder in its earliest stages,” adds Giuffrida.

If you or a loved one could have a better quality of life through your ALS ordeal, would you say yes to Cannabis?

Sources: Science Daily, ALS News Today, Leafly

20 things to know regarding Pharmaceutical vs. Nutraceutical protocols for ALS!

ALS, Blog, Deanna Protocol, disability, Resources, simplesa, Supplements, , , , , , , ,

Radicava® vs Deanna Protocol®

To understand what the differences between Pharmaceutical and Nutraceutical are, we should begin with their definitions:

phar·ma·ceu·ti·cal

Adjective

  1. Relating to medicinal drugs, or their preparation, use, or sale.

Noun

  1. a compound manufactured for use as a medicinal drug.

nu·tra·ceu·ti·cal

Noun

Plural noun: nutraceuticals 

a food containing health-giving additives and having medicinal benefit.

Now, let’s compare the new drug approved by the FDA Radicava® vs The Natural alternative for a better quality of life, the Deanna Protocol®.

  • 10 Things to Know About the New ALS Drug Radicava®
  1. It is a Pharmaceutical drug.
  2. The drug underwent a phase 3 clinical trial in Japan and South Korea where 137 ALS patients were given either Radicava® or a placebo. The group given Radicava® experienced a 33 percent reduction in the decline of their physical abilities compared to the placebo group.
  3. Radicava® works by reducing the oxidative stress in the body. People with ALS have high levels of oxidative stress.
  4. Radicava® is administered via intravenous infusions. Initially, patients have a daily infusion for two weeks and then have two weeks’ rest. After that, they need to have 10 consecutive daily infusions followed by two weeks of rest.
  5. Each infusion takes around an hour to complete.
  6. The dosage of each infusion is 60 mg.
  7. The cost of each Radicava® infusion is about $1,000 and it’s reported that the treatment costs about $146,000 annually.
  8. Radicava® should be available to ALS patients in the U.S. by August.
  9. The most common side effects associated with the drug are headaches, bruising and gait problems.
  10. Radicava® infusion contains sodium bisulfite which is known to cause both mild and severe allergic reactions in some people (particularly those with asthma).
  • 10 Things to Know About the Deanna Protocol®
  1. It is a naturally derived Nutraceutical program.
  2. Developed by Doctor Vincent Tedone, a retired physician (Orthopedic Surgeon), for his daughter Deanna who was diagnosed with ALS at the age of 30 in 2007.
  3. The Deanna Protocol® has undergone double blind clinical trials at the University of South Florida in mice models. The Deanna Protocol® has over 1,500 anecdotal case studies from patients with ALS.
  4. The Deanna Protocol® is a blend of nutritional powders and liquids that contain powerful antioxidants and amino acids essential to assist your body in its natural efforts to fight neurodegenerative damage. People suffering from other neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, have also reported improvements.
  5. It is taken in the morning, in the afternoon and at night as part of your regular, at home, breakfast, lunch and dinner routine. No need to go to the clinic.
  6. The Protocol is the same for everyone but the dosages might vary, depending on the person and what their specific needs are. The most common side effect is an upset stomach usually reported during the initial days as the body adjusts to the protocol.
  7. The cost of the Deanna Protocol® starts at $219.99 for the Core Bundle #1. The next most inclusive package is the Plus Bundle #1 at $249.99. And our most inclusive bundle is the Comprehensive Bundle #1 at $349.99. Above prices are for a 1 month supply and include easy-to-follow, step-by-step instructions and an actual human to answer your questions and provide you with the support you need.
  8. Not sure? At Simplesa’s website there’re 330+ reviews with 4.5 stars from verified and satisfied buyers at simplesanutrition.com or call 1-888-578-5528.
  9. Deanna Protocol® has been in the market for almost 4 years. The popularity of the protocol and the positive reports from the clients, speak for themselves.
  10. The freshness of the products used in the Deanna Protocol is guaranteed, these products are naturally derived and are manufactured in a facility that follows strict Current Good Manufacturing Practice (cGMP) (Enforced by the FDA) and is UL (Underwriters Laboratories) certified.

 This Blog is for educational purposes. We hope that the above information helps you make the right decisions to address your neuro-degenerative concerns. And as always consult your physician.

 If you liked this article, please share with others
that could benefit from this information.
Remember Sharing is Caring!

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.

Sources:
alsnewstoday.com
winningthefight.org
simplesanutrition.com/deanna-protocol/

 

B12 the Powerhouse Energy Vitamin – Try Simplesa Liposomal

Blog, Nutrition, Resources, , , , , , , , ,

Simplesa B12Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.[1]

What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.

Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.[2]

Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.[3]

Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions.  An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.

As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.[4]

Do I have a B12 deficiency?
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:

·         strange sensations, numbness, or tingling in the hands, legs, or feet

·         difficulty walking (staggering, balance problems)

·         anemia

·         a swollen, inflamed tongue

·         yellowed skin (jaundice)

·         difficulty thinking and reasoning (cognitive difficulties), or memory loss

·         paranoia or hallucinations

·         weakness

·         fatigue

While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.[5]

How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin.  Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.

Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain.  Simplesa Liposomal Vitamin B12   does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.

Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it. [6] Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.

Some of the many benefits of Simplesa Liposomal Vitamin B12:

·         Contributes to normal red blood cell formation

·         Supports the nervous system and mental functions

·         Contributes to a normal, healthy metabolism

·         Is essential for a healthy heart

Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil.  It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.

For more information or to try our new Simplesa Liposomal Vitamin B12 click here.

[1] https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
[2] http://www.health.com/health/gallery/0,,20924065,00.html
[3] http://www.medicalnewstoday.com/articles/219822.php
[4]  http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[5] http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[6] http://www.livestrong.com/article/289321-sublingual-vitamin-b12-vs-injectable-b12/

Lunasin and Its Benefits

ALS, Blog, LunaCell, Lunasin, Supplements, , , , ,

Lunasin has been getting a lot of press, research and attention for benefiting a variety of health conditions. It is important to understand the science behind Lunasin, and how it can help your body.

Lunasin is natural, and found in soy, barley, and rye.  It is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus.

Proteins and peptides are fundamental components of cells that carry out important biological functions. Proteins give cells their shape, for example, and they respond to signals transmitted from the extracellular environment. Certain types of peptides play key roles in regulating the activities of other molecules. Structurally, proteins and peptides are very similar, being made up of chains of amino acids that are held together by peptide bonds (also called amide bonds).

So, what distinguishes a peptide from a protein?

The basic distinguishing factors are size and structure. Peptides are smaller than proteins. Traditionally, peptides are defined as molecules that consist of between 2 and 50 amino acids, whereas proteins are made up of 50 or more amino acids. In addition, peptides tend to be less well defined in structure than proteins, which can adopt complex conformations known as secondary, tertiary, and quaternary structures. [1]

Lunasin is a “bioactive” peptide which means it is a compound that influences living things and their core elements – like tissue and cells. Bioactive compounds have been shown via research and studies to have an influence on health. Areas of Lunasin research have focused on cancer, cholesterol, cardiovascular, inflammation, skin health and anti-aging.  Let’s examine these studies and how the science supports the benefits of Lunasin on your health and well-being.

Cancer

For over a decade research has shown “Lunasin as a cancer-preventive soy peptide.”[2] Memorial Sloan Kettering Cancer Center indicated that:

Studies in animals suggest that soy can prevent or reduce bone loss. In laboratory studies, iso- flavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. Animal studies showed that genistein, one of the isoflavones, may interfere with tamoxifen that is used for breast cancer. But a new study showed that soy foods can benefit women with breast cancer. Patients should consult their physicians about use of soy supplements.[3]

Skin Health

In 2017 a study stated that “The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells” and concluded that “Our studies suggest that Lunasin represents a unique anticancer agent that could be developed to help prevent metastasis and patient relapse by reducing the activity of CICs which are known to be resistant to current chemotherapies.”[4]

Cholesterol & Cardiovascular Health

The 2016 study “Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease” published by American Heart Association, Inc. found that:

Soy protein has an approved FDA health claim for reducing LDL cholesterol and CVD risk but the active component and mechanism of action are unknown. They tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol.

Using a lunasin bioactivity assay, we were able to produce a lunasin-enriched soy extract (LSE) containing 100-200-fold more bioactive lunasin than soy protein isolates. To test the in vivo efficacy of LSE, we conducted a food supplementation experiment on five pigs that have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE every day for eight weeks. Blood draws and lipid panel testing were done at -2w (before casein diet), 0w (2 weeks casein), 4w (4w casein + 250 mg LES) and 8w (8w casein + 250 mg LES). Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in case in diet reduced LDL cholesterol by 8.6% and 6.4% after 4 and 8 weeks of treatment, respectively. These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.[5]

Inflammation

Inflammation has an impact on all areas of health and well-being.

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic diseases such as cancer. Lunasin is a novel peptide that demonstrates potential anticancer activity against mammalian cancer cell lines and may play a role in inflammation. In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced.[6]

Although inflammation is linked in the public mind with chronic health problems such as heart disease, diabetes, and rheumatoid arthritis, de Mejia said it also plays a role in the development of cancer. “We know that chronic inflammation is associated with an increased risk of malignancies, that it’s a critical factor in tumor progression,” she said. “And we can see that daily consumption of lunasin-rich soy protein may help to reduce chronic inflammation.[7]

Obesity

A study in 2017 examined the relationship between inflammation and obesity. The study was called “Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production”.

This study indicated that lunasin is not only effective against inflammatory response of RAW264.7 macrophages, but also highlights this suppressive property on 3T3-L1 adipocytes, and disrupts the crosstalk between macrophages and adipocytes, particularly by inhibiting secretion of pro-inflammatory mediators, might benefit to ameliorate obesity-induced inflammatory diseases.[8]

Anti-Aging

Lunasin has been shown to help with anti-aging. Epigenetics shows the relationship of Lunasin to aging. Epigenetics is the study of long-term changes in chromosomes that don’t involve alterations in the genetic code.

But perhaps the most exciting area of aging epigenetics is the recent notion of an epigenetic clock, called Horvath’s clock, after its discoverer. The gist of it is that there is a strong association between the amount of genome-wide methylation and mortality. A lot of the genome is methylated when we are young but methylation is reduced in a constant clock-like way as we age. Methylation, recall, tends to silence genes. With age, it appears, an increasing number of genes that should be silenced are not, rendering us more susceptible to all manner of ailments. From reading the amount of methylation in the epigenome, scientists can predict an individual’s age with impressive accuracy.[9]

If you can utilize Lunasin to regulate or reset epigenetic implications of aging, then some studies believe we can reverse it.  One such study, examined this aspect of utilizing Lunasin for anti-aging. “Histone Modifications and Epigenetic Regulation Could Hold the Key to Reversing Aging” found that:

Results from a recent study conducted by researchers at the University of Pennsylvania show that yeast could help advance our progress in extending life in human cells. The team of researchers included Shelley Berger, PhD, professor in Cell & Developmental Biology and Biology & Genetics departments at the Perelman School of Medicine, Weiwei Dang, PhD, assistant professor at Baylor College of Medicine and former postdoc fellow at Penn, and Payel Sen, PhD, a current postdoc fellow in Berger’s lab. The study was published in Genes & Development and focused on how a certain epigenetic histone modification could extend yeast’s lifespan.

“Researchers have just started to appreciate how these epigenetic histone modifications may be playing essential roles in determining lifespan,” said Berger. She has conducted studies on epigenetic marks for more than 20 years and was one of the first to identify histone modifications that are altered during aging and directly impact longevity.

Dang explained that their study pinpointed a type of abnormal transcription that is significantly increased in older cells and, if reduced, can lengthen lifespan in yeast. He started the research when he was working in Berger’s lab.

He explained that “this longevity effect is mediated through an evolutionarily conserved chemical modification on histones [and] this is the first demonstration that such a mechanism exists to regulate aging.”

Although measuring aging in yeast is quite different from measuring human aging, Sen noted that using a budding yeast single-cell organism model turned out to be surprisingly powerful in their study of aging and epigenetic regulation.[10]

The research, science and benefits of Lunasin are clearly seen in these and many other scientific studies.

lunacell

 

 

Simplesa LunaCell™ is the most advanced Lunasin supplement on the market today. LunaCell™ has more than twice the concentration of bioavailable Lunasin than any other product available.  If you understand the science, then the choice is clear – choose LunaCell™!!

 

 

 

[1] https://www.britannica.com/demystified/what-is-the-difference-between-a-peptide-and-a-protein

[2] https://www.ncbi.nlm.nih.gov/pubmed/15730231

[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/soy

[4] https://www.ncbi.nlm.nih.gov/pubmed/28424421

[5] http://circ.ahajournals.org/content/126/Suppl_21/A10693

[6] http://www.sciencedirect.com/science/article/pii/S0196978109003416

[7] https://www.sciencedaily.com/releases/2009/12/091202153946.htm

[8] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171969

[9] http://goop.com/understanding-epigenetics-and-what-it-means-for-aging-cancer-and-obesity/

[10] https://www.whatisepigenetics.com/histone-modifications-and-epigenetic-regulation-could-hold-the-key-to-reversing-aging/

In Support of Parkland, Florida

Blog, Support, , ,

As you may be aware, Simplesa is located in Coral Springs, Florida, the city adjacent to Parkland where the horrific school shooting took place earlier this week. Our thoughts and prayers go out to all those affected by the recent events. In support of our local community, Simplesa will be donating a portion of its proceeds for the rest of February to the victims and support efforts for those tragically affected. We invite you to join us in this cause.

simplesaparkland
In Support of Parkland, FL
For those customers looking to stock up on products before the end of the month, we are offering the following discounts:

Spend $200 during the rest of February and
get $15.00 OFF
use coupon code:
HEARTS4PARKLAND15

Spend $300 during the rest of February and
get $30.00 OFF
use coupon code:
HEARTS4PARKLAND30

Spend $500 during the rest of February and
get $65.00 OFF
use coupon code:
HEARTS4PARKLAND65

Spend $700 during the rest of February and
get $100.00 OFF
use coupon code:
HEARTS4PARKLAND100

parklandpromo

INTRODUCING OUR 2018 LOYALTY PROGRAM

Blog, Deanna Protocol, LunaCell, Lunasin, Nutrition, Resources,

We are pleased to launch our new 2018 Simplesa Loyalty Program. This program will enable you to earn rewards on your Simplesa purchases that can be used for discounts on future orders. Importantly, there is no expiration date on the points you earn. Get points for all your orders, and sometimes we’ll offer special opportunities to earn bonus points. You can keep track of your points by logging into your Simplesa account. Thank you for being a valued customer.

 

Simplesa Rewards Overview

SimplesaLoyalty

175 Points = $5 Voucher

330 Points = $10 Voucher

600 Points = $15 Voucher

900 Points = $25 Voucher

1,100 Points = $35 Voucher

1,500 Points = $50 Voucher

2,100 Points = $75 Voucher

2,600 Points = $100 Voucher

3,750 Points = $150 Voucher

4,000 Points = $200 Voucher

 

Start Earning Points

FREQUENTLY ASKED QUESTIONS
● How do I enroll?
To enroll, you just have to create an account at SimplesaNutrition.com
● Do I have to enroll if I am already a Customer?
We have already enrolled everyone with an active account and even rewarded you with 50 points to start the New Year.
● When does the program begin?
The program begins January 1st, 2018

 

 

 

 

 

 

simplesafooteremail

Tips for Caregivers

Deanna Protocol, Nutrition, Resources, Supplements, , , ,

 caregivingCaregiving – It’s one of the hardest, physically and emotionally draining roles anyone can undertake.  In a 2015 survey from AARP and the National Alliance of Caregiving it was found that a third of all Americans are caregivers, providing care to someone who is disabled, ill or elderly.  The same study found that almost 80% of these caregivers stated they needed help.[1] Caregivers can be family members or friends. Many caregivers have jobs, families, and the additional responsibility of the minute to minute needs of the person to whom they are providing care 24/7.  It is not just driving to doctor visits or making meals. Many caregivers are providing nursing care (maintaining Stomas, catheters, or feeding tubes), often without the training or previous experience to do so. Caregivers learn quickly as the lives and well-being of someone they love relies on them. Perhaps the person being cared for is not a good patient, or does not remember you, or has tremendous guilt in being ill or helpless. These are all potential circumstances that many caregivers have to face every day. It’s one of the experiences in life that unless you have done it – you won’t quite understand the demands or the challenges.

Tips for Caregiver:

The first rule of taking care of others: take care of yourself first. Caregiving can be a rewarding experience, but it is also physically and emotionally demanding. The stress of dealing with caregiving responsibilities leads to a higher risk of health issues among the nation’s 90 million family caregivers. So as a family caregiver, remember to pay attention to your own physical and mental wellness, and get proper rest and nutrition. Only by taking care of yourself can you be strong enough to take care of your loved one. You really do need to “take care to give care!”

  • Caregiving can be a stressful job. Most family caregivers say they feel stressed providing care for a loved one. With all of their caregiving responsibilities – from managing medications to arranging doctor appointments to planning meals – caregivers too often put themselves last.
  • The stress of caregiving impacts your own health. One out of five caregivers admit they have sacrificed their own physical health while caring for a loved one. Due to stress, caregivers have a disproportionate number of health and emotional problems. They are twice as likely to suffer depression and are at increased risk for many other chronic conditions.
  • Proper nutrition helps promote good health. Ensuring that you are getting proper nutrition is key to help maintain your strength, energy and stamina, as well as strengthening your immune system. Maintaining a healthy diet is one of the most powerful things you can do to take care of yourself and keep a positive attitude overall.
  • Ensuring good nutrition for your loved one helps make care easier. As many as half of all older adults are at risk for malnutrition. Good nutrition can help maintain muscle health, support recovery, and reduce risk for re-hospitalization – which may help make your care of a loved one easier.
  • Remember: “Rest. Recharge. Respite.” People think of respite as a luxury, but considering caregivers’ higher risk for health issues from chronic stress, those risks can be a lot costlier than some time away to recharge. The chance to take a breather, the opportunity to re-energize, is vital in order for you to be as good a caregiver tomorrow as you were today.[2]

What is Respite?

According to the Lifespan Respite Care Act (PL 109-442), Lifespan Respite is defined as ‘coordinated systems of community-based respite for family caregivers of children or adults regardless of special need.’  For more information, on Respite please visit: https://archrespite.org/index.php

Tips for Others:

As a caregiver your world at times feels like it’s in chaos and out of your control.  Interacting with other people can often be tiresome and difficult as you simply feel too overwhelmed to participate in social settings. Other people often want to help and support you, but struggle with what they can say and do to help.  We have compiled some great suggestions for what to say or not to say to caregivers.  Please feel free to send suggestions we have not mentioned in this blog. Interesting enough, there is some overlap on the advice on what best to say or not to say to caregivers. Bottom line:  speak from the heart and be supportive of their needs.

12 Things You Should Say to a Family Caregiver By Becky Benishek

Keep in mind many caregivers won’t ask for help, so the best way to help someone is to do things for them that they may not have the time, money, or mental energy to do for themselves. Social settings and activities may at times be too draining, or the fear of being a “bummer” or not in “the best mood” can often cause many caregivers to go into recluse mode.

A Dozen Things You Should Never Say to A Caregiver by Ann Brenoff

There is assistance and resources to help caregivers.  Many times a caregiver is so consumed in the day to day tasks of caregiving they don’t have the bandwidth to research tools or support.  One such resource is geared to caregivers of Veterans.  Per the Veteran Benefits: Caregiver Programs and Services on Military.com website:

On May 5, 2010, the Caregivers and Veterans Omnibus Health Services Act of 2010 was signed into law. Title I of the Act will allow VA to provide unprecedented benefits to eligible Caregivers (a parent, spouse, child, step-family member, extended family member, or an individual who lives with the Veteran, but is not a family member) who support the Veterans who have given so much for this Nation. The law distinguishes between Veterans who incurred or aggravated a serious injury in the line of duty on or after Sept. 11, 2001 (post-9/11 Veterans), and those Veterans whose injuries were incurred prior to Sept. 11, 2001 (pre-9/11 Veterans).

Please visit the VA’s caregiver page for more information, and to apply for these services.

 Caregivers Toolbox:

http://caregiveraction.org/family-caregiver-toolbox

http://www.caregiving.org/resources/

http://www.rosalynncarter.org/caregiver_resources/

https://www.medicare.gov/campaigns/caregiver/caregiver.html

http://www.aarp.org/home-family/caregiving/?cmp=RDRCT-CRGNG_APR12_012

http://www.easterseals.com/explore-resources/for-caregivers/understanding-aging-and-caregiving.html

Footnotes:

[1] http://www.huffingtonpost.com/entry/a-dozen-things-you-should-never-say-to-a-caregiver_us_5621409fe4b08589ef474317

[2] http://caregiveraction.org/national-family-caregivers-month-theme/

Complementary Regimes of Lunasin and Deanna Protocol® for Veterans

ALS, Blog, Deanna Protocol, LunaCell, Lunasin, veterans

VeteVrans Day is an important time to raise awareness of the ongoing health, physical and mental issues encountered by veterans during and after service. Recent studies show that veterans have a 60 percent higher risk of getting ALS than the general population.

“We don’t know what about service could lead to increased risk of the disease in veterans,” said Patrick Wildman, vice president of public policy for the ALS Association. “It could be a variety of factors from head trauma and excessive physical activity to exposures. It also could be a combination of a genetic predisposition with an environmental trigger.” The Mayo Clinic surmises that reasons for the connection “may include exposure to certain metals or chemicals, traumatic injuries, viral infections and intense exertion” but says that “exactly what about military service may trigger the development of ALS is uncertain.”[1]

These statistics are so staggering and alarming that Veterans Affairs has made ALS automatically service connected.

It doesn’t matter in which era the veterans served. From World War II through the Gulf War and even in peacetime, multiple studies show that the rate at which vets develop the condition is still twice as high as non-vets. In fact, the evidence is so convincing the Department of Veterans Affairs has assumed since 2008 that a veteran’s ALS is automatically service-connected.[2]

Finding ways to combat the onset or slow the progression of ALS is critical for patients with ALS (PALS) until a cure is found. Improving the quality of life for all those with ALS is a focus for Simplesa®.  The Deanna Protocol® (DP) is an all-natural metabolic program that works to support mitochondria dysfunction with energy production and counteracting oxidative stress. DP helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[3] Lunasin was the first dietary compound with an identified epigenetic mechanism of action. PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals. Research indicates that veterans with ALS and/or similar neurological issues have damage that is receptive to epigenetic therapies like Lunasin.

Dr. Richard Bedlack, Professor and Director of the ALS Clinic at Duke University, is conducting a study on Lunasin in 50 ALS patients. The study is a first of a kind clinical study that is investigating the efficacy of Lunasin in the support of ALS. It’s the fastest enrollment study ever conducted in their history. The clinical trial is based on Mike McDuff, an ALS patient who showed a remarkable reversal after taking bioactive Lunasin. He gained back his weight, went off his feeding tube and could talk again. Not all people will have the same results, but it greatly improved Mike’s quality of life.[4]

 

lunacell

Simplesa® is committed to helping veterans. They have a dedicated customer support staff of veterans to assist with questions about Simplesa’s Lunasin product called LunaCell™ and the Deanna Protocol®.

Simplesa® has always been steadfast to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. These two complementary regimes provide additional choices for PALS to help improve their quality of life.

For additional information on available veteran resources contact: http://www.pva.org

Sources:

[1] http://www.cnn.com/2015/11/11/health/als-and-military-veterans/index.html

[2] www.wearethemighty.com/veterans/military-veterans-are-twice-as-likely-to-get-als-and-no-one-knows-why

[3] www.mndassociation.org/wp-content/uploads/FINAL-WIP-booklet-Dublin-081116.docx

[4] lunasin.com/studies

 

Related Links

Deanna Protocol® Program for ALS

LunaCell

Related Video

http://www.youtube.com/watch?v=tOKoesaCh7M

Simplesa® is now offering the Deanna Protocol® and Lunasin to ALS Patients

ALS, Blog, Deanna Protocol, disability, LunaCell, Lunasin, Supplements

Simplesa, a nutrition company established in 2013 after the amyotrophic lateral sclerosis (ALS) community showed its support for a metabolic supplement treatment called the Deanna Protocol (DP), has expanded its products for the Deanna Protocol with the addition of LunaCell™ for consumers.

Patients with ALS (PALS) have been following the Deanna Protocol (DP) since it was first released in 2011. The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone, a retired physician whose daughter, Deanna, was diagnosed with ALS. The Deanna Protocol works to support mitochondria dysfunction with energy production and the counteracting oxidative stress. The Deanna Protocol (DP) helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

lunacellLunasin first caught the attention of physicians and the ALS community when Mike McDuff, who was diagnosed with ALS, took the nutrient in 2012 and had a remarkable recovery. Therefore, Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[1] Lunasin was the first dietary compound with an identified epigenetic mechanism of action.  PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals.    Since that time, Lunasin has caught the attention of many trying to cure and/or treat ALS.  Among those interested in Lunasin and ALS is Dr. Richard Bedlack, Director of the ALS Clinic at Duke University. He started the first of its kind study on Lunasin with reporting conducted through a patient network and real-time research platform called Patients Like Me.

As with the Deanna Protocol, Simplesa saw the potential to help PALS with Lunasin.  Simplesa® recently released its Lunasin product, LunaCell™, which consists of a superior bioavailable form of Lunasin and is priced relatively lower than other Lunasin products. This formulation allows patients to take less capsules and quickly absorb more Lunasin into their system.

Feedback from verified consumers of the products has been very positive:

It seems impossible but after two days my dad muscle movement on leg that is useless for more than a year. – Andrej

 

I only take half of the capsules and it costs half as much as other Lunasin I took. Thank you. – Pedro O.

Simplesa® has always been committed to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. This new program is opening doors for additional choices for PALS to try both complimentary regimes and improve their quality of life.

Sources:

  1. Oxidative Stress and Radivcava: 

https://alsnewstoday.com/2017/08/03/nine-things-to-know-about-the-new-als-drug-radicava/

  1. Oxidative Stress and Lunasin:

https://core.ac.uk/download/pdf/3616328.pdf

  1. Oxidative Stress and Deanna protocol: 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103526

https://www.researchgate.net/publication/272828777_ALS_Untangled_No_20_the_Deanna_protocol

[1]www.mndassociation.org%2Fwp-content%2Fuploads%2FFINAL-WIP-booklet-Dublin-081116.docx&usg=AOvVaw0QgHpgvjCAB2Dae8-77Ins

The Science Behind Lunasin and Its Benefits

ALS, LunaCell, Lunasin, Supplements, , , , ,

Lunasin has been getting a lot of press, research and attention for benefiting a variety of health conditions. It is important to understand the science behind Lunasin, and how it can help your body.

Lunasin is natural, and found in soy, barley, and rye.  It is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus.

Proteins and peptides are fundamental components of cells that carry out important biological functions. Proteins give cells their shape, for example, and they respond to signals transmitted from the extracellular environment. Certain types of peptides play key roles in regulating the activities of other molecules. Structurally, proteins and peptides are very similar, being made up of chains of amino acids that are held together by peptide bonds (also called amide bonds).

So, what distinguishes a peptide from a protein?

The basic distinguishing factors are size and structure. Peptides are smaller than proteins. Traditionally, peptides are defined as molecules that consist of between 2 and 50 amino acids, whereas proteins are made up of 50 or more amino acids. In addition, peptides tend to be less well defined in structure than proteins, which can adopt complex conformations known as secondary, tertiary, and quaternary structures. [1]

Lunasin is a “bioactive” peptide which means it is a compound that influences living things and their core elements – like tissue and cells. Bioactive compounds have been shown via research and studies to have an influence on health. Areas of Lunasin research have focused on cancer, cholesterol, cardiovascular, inflammation, skin health and anti-aging.  Let’s examine these studies and how the science supports the benefits of Lunasin on your health and well-being.

Cancer

For over a decade research has shown “Lunasin as a cancer-preventive soy peptide.”[2] Memorial Sloan Kettering Cancer Center indicated that:

Studies in animals suggest that soy can prevent or reduce bone loss. In laboratory studies, iso- flavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. Animal studies showed that genistein, one of the isoflavones, may interfere with tamoxifen that is used for breast cancer. But a new study showed that soy foods can benefit women with breast cancer. Patients should consult their physicians about use of soy supplements.[3]

Skin Health

In 2017 a study stated that “The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells” and concluded that “Our studies suggest that Lunasin represents a unique anticancer agent that could be developed to help prevent metastasis and patient relapse by reducing the activity of CICs which are known to be resistant to current chemotherapies.”[4]

Cholesterol & Cardiovascular Health

The 2016 study “Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease” published by American Heart Association, Inc. found that:

Soy protein has an approved FDA health claim for reducing LDL cholesterol and CVD risk but the active component and mechanism of action are unknown. They tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol.

Using a lunasin bioactivity assay, we were able to produce a lunasin-enriched soy extract (LSE) containing 100-200-fold more bioactive lunasin than soy protein isolates. To test the in vivo efficacy of LSE, we conducted a food supplementation experiment on five pigs that have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE every day for eight weeks. Blood draws and lipid panel testing were done at -2w (before casein diet), 0w (2 weeks casein), 4w (4w casein + 250 mg LES) and 8w (8w casein + 250 mg LES). Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in case in diet reduced LDL cholesterol by 8.6% and 6.4% after 4 and 8 weeks of treatment, respectively. These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.[5]

Inflammation

Inflammation has an impact on all areas of health and well-being.

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic diseases such as cancer. Lunasin is a novel peptide that demonstrates potential anticancer activity against mammalian cancer cell lines and may play a role in inflammation. In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced.[6]

Although inflammation is linked in the public mind with chronic health problems such as heart disease, diabetes, and rheumatoid arthritis, de Mejia said it also plays a role in the development of cancer. “We know that chronic inflammation is associated with an increased risk of malignancies, that it’s a critical factor in tumor progression,” she said. “And we can see that daily consumption of lunasin-rich soy protein may help to reduce chronic inflammation.[7]

Obesity

A study in 2017 examined the relationship between inflammation and obesity. The study was called “Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production”.

This study indicated that lunasin is not only effective against inflammatory response of RAW264.7 macrophages, but also highlights this suppressive property on 3T3-L1 adipocytes, and disrupts the crosstalk between macrophages and adipocytes, particularly by inhibiting secretion of pro-inflammatory mediators, might benefit to ameliorate obesity-induced inflammatory diseases.[8]

Anti-Aging

Lunasin has been shown to help with anti-aging. Epigenetics shows the relationship of Lunasin to aging. Epigenetics is the study of long-term changes in chromosomes that don’t involve alterations in the genetic code.

But perhaps the most exciting area of aging epigenetics is the recent notion of an epigenetic clock, called Horvath’s clock, after its discoverer. The gist of it is that there is a strong association between the amount of genome-wide methylation and mortality. A lot of the genome is methylated when we are young but methylation is reduced in a constant clock-like way as we age. Methylation, recall, tends to silence genes. With age, it appears, an increasing number of genes that should be silenced are not, rendering us more susceptible to all manner of ailments. From reading the amount of methylation in the epigenome, scientists can predict an individual’s age with impressive accuracy.[9]

If you can utilize Lunasin to regulate or reset epigenetic implications of aging, then some studies believe we can reverse it.  One such study, examined this aspect of utilizing Lunasin for anti-aging. “Histone Modifications and Epigenetic Regulation Could Hold the Key to Reversing Aging” found that:

Results from a recent study conducted by researchers at the University of Pennsylvania show that yeast could help advance our progress in extending life in human cells. The team of researchers included Shelley Berger, PhD, professor in Cell & Developmental Biology and Biology & Genetics departments at the Perelman School of Medicine, Weiwei Dang, PhD, assistant professor at Baylor College of Medicine and former postdoc fellow at Penn, and Payel Sen, PhD, a current postdoc fellow in Berger’s lab. The study was published in Genes & Development and focused on how a certain epigenetic histone modification could extend yeast’s lifespan.

“Researchers have just started to appreciate how these epigenetic histone modifications may be playing essential roles in determining lifespan,” said Berger. She has conducted studies on epigenetic marks for more than 20 years and was one of the first to identify histone modifications that are altered during aging and directly impact longevity.

Dang explained that their study pinpointed a type of abnormal transcription that is significantly increased in older cells and, if reduced, can lengthen lifespan in yeast. He started the research when he was working in Berger’s lab.

He explained that “this longevity effect is mediated through an evolutionarily conserved chemical modification on histones [and] this is the first demonstration that such a mechanism exists to regulate aging.”

Although measuring aging in yeast is quite different from measuring human aging, Sen noted that using a budding yeast single-cell organism model turned out to be surprisingly powerful in their study of aging and epigenetic regulation.[10]

The research, science and benefits of Lunasin are clearly seen in these and many other scientific studies.

lunacell

 

 

Simplesa LunaCell™ is the most advanced Lunasin supplement on the market today. LunaCell™ has more than twice the concentration of bioavailable Lunasin than any other product available.  If you understand the science, then the choice is clear – choose LunaCell™!!

 

 

 

[1] https://www.britannica.com/demystified/what-is-the-difference-between-a-peptide-and-a-protein

[2] https://www.ncbi.nlm.nih.gov/pubmed/15730231

[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/soy

[4] https://www.ncbi.nlm.nih.gov/pubmed/28424421

[5] http://circ.ahajournals.org/content/126/Suppl_21/A10693

[6] http://www.sciencedirect.com/science/article/pii/S0196978109003416

[7] https://www.sciencedaily.com/releases/2009/12/091202153946.htm

[8] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171969

[9] http://goop.com/understanding-epigenetics-and-what-it-means-for-aging-cancer-and-obesity/

[10] https://www.whatisepigenetics.com/histone-modifications-and-epigenetic-regulation-could-hold-the-key-to-reversing-aging/

Simplesa® Announces the Launch of LunaCell™ – Most Advanced Form of Lunasin™

LunaCell, Lunasin,

LunaCell™ is the next generation and most bioactive form of Lunasin available

CORAL SPRINGS, Fla., July 13, 2017 /PRNewswire/ — Simplesa® is launching LunaCell™, the next generation of Lunasin developed to have superior bioavailability.  LunaCell™ is the culmination of years of research, studies, patents, and technology that has been invested into making Lunasin more absorbable by the body.  Developed by the original Lunasin Research & Development Team, and now working with Simplesa®, LunaCell™ is produced using the most advanced extraction, processing, and standardizing techniques.  This makes LunaCell™ the most concentrated and efficient form of Lunasin ever produced. LunaCell delivers more bioavailable Lunasin than any other Lunasin supplement on the market today, all in a smaller and easier to swallow capsule.

LunaCell™ is the next generation and most bioactive form of Lunasin available
LunaCell™ is the next generation and most bioactive form of Lunasin available

Lunasin was originally developed as the first dietary compound with an identified epigenetic mechanism of action.  This mechanism (histone acetylation) was identified in 1996 and patented in 1999.  While many other dietary compounds are known to affect gene expression, their exact mechanisms of action (how they work) remain unknown.  The ground-breaking work identifying Lunasin’s epigenetic mechanism of action has been published in Nature Biotechnology and Cancer Research.  Epigenetics affect how genes are interpreted by our cells and subsequently react or reproduce new cells.1 Multiple studies have shown that Lunasin helps reduce oxidation of linoleic acid that produces oxygen radicals and acts as an oxygen radical scavenger (traditional antioxidant mechanism). It also reduces oxygen radicals produced by macrophages.

Free radicals are atoms or molecules that are highly reactive with other cellular structures because they contain unpaired electrons. As free radicals react with cellular structures, they lead to cellular injury and eventually cell death2. Free radicals may also trigger activation of various proteins that in turn activate an inflammatory response. Abnormally activated macrophages are highly specialized cells in our bodies that remove dying or dead cells and cellular debris, causing elevated levels of free radicals. LunaCell™ helps prevent and counteract cell damage and encourages healthy expression of cell growth and activity.

LunaCell™ is the effective and potent combination of Lunasin and protease inhibitors, which together deliver bioavailable Lunasin to the body.  In LunaCell, the Lunasin molecule is encased by protease inhibitors to form a protective shell which serves to prevent premature Lunasin destruction during digestion. As the molecule passes through the small intestine, the protease inhibitors break down to release bioavailable Lunasin for optimal absorption by the body. This is an important and distinctive factor of LunaCell™, as, without this protective coating, the Lunasin will break down too early during digestion, resulting in a loss of potency and maximum intake by the body.  It is the combination of Lunasin and the protease inhibitors in LunaCell™ that makes it the best choice for superior absorption by the body.

Simplesa® vice president Steve Margolis noted that “LunaCell™ is the most advanced Lunasin supplement available on the market today.  We saw LunaCell as an amazing and groundbreaking opportunity. We are always eager to advocate solutions that help people keep their supplemental and nutritional regimes simple.”

Beyond the improved bioavailability and absorption, the practical aspect of LunaCell™ is very important.  It offers more convenience and cost savings compared to other brands of Lunasin on the market. Since LunaCell has twice the potency of the Lunasin as other products, someone only needs to take half the number of capsules.  Moreover, the capsules are now smaller and therefore easier to swallow. LunaCell™ is practical, cost effective, and has easier dosing.

For more product information about LunaCell™ please visit: Simplesa.com/LunaCell

1 http://lunasin.com/lunasin-and-epigenetics

2 http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/?s=inflammation#free-radicals

Lyme Disease and ALS – Summer 2017

Blog, Uncategorized, ,

There is a lot of controversy regarding the connection between Lyme disease and ALS.

To understand the debate, let’s discuss some basics of both diseases as described by the experts.

lymediseaseimage

What is Lyme Disease:

Most people know that you get Lyme Disease from an infected tick, but many people don’t understand or realize the damage caused by Lyme Disease. If left untreated, the disease can lead to severe and life threatening medical issues.

“Lyme disease, the most common vector-borne illness in the United States, is a multi-system illness usually caused by infection with the spirochete Borrelia burgdorferi and the body’s immune response to the infection.[1] The disease is transmitted to humans via tick bites, from infected ticks of the genus Ixodes.”[1]

What is Amyotrophic Lateral Sclerosis (ALS)?

ALS is a progressive neurodegenerative disorder for which there is no cure.  Life expectancy following a diagnosis is two to five years.

“Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig’s disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) that are responsible for controlling voluntary muscles (muscle action we are able to control, such as those in the arms, legs, and face). This disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons.”[2]

How are these two diseases different?

ALS is currently an incurable disease. Lyme disease can be treated when discovered in a timely manner by antibiotics. If left untreated, Lyme disease can result in devastating medical problems and death. Lyme disease is known to mimic many of the symptoms of other diseases causing issues on diagnosis and subsequent treatment.

Because ALS and Lyme disease can exhibit similar symptoms, incidents of misdiagnosis of Lyme Disease as ALS have been reported.  This very recent case reported by NBC highlights a misdiagnosis of ALS when the patient actually had Lyme disease. The patient’s doctor insisted he had ALS, and they accepted the reality of this diagnosis.

“Matt remembered.”He said, “Enough’s enough. The reality is, you have ALS, and you know, you really need to embrace what I am telling you.” Matt’s family was told to help him come to terms with his death.

But inside their home, the Slatner family was doing their own research on Lyme symptoms and everything kept pointing to those tick bites.

“Every single thing is a Lyme symptom,” Stephanie said, remembering the long days and nights of research, three busy kids, and a husband who was slowly fading away. “No one would listen. I mean, they made us both feel like we were crazy.”[3]

Does everyone with ALS have Lyme?

“Lyme disease does not cause ALS, and generally in a diagnostic workup, a neurologist can easily separate ALS from Lyme infections, either clinically or with testing.”[4]

Despite the current belief that Lyme disease does not cause ALS, some studies have shown that many PALS do test positively for Lyme. This has caused a lot of disagreement between physicians and patients citing high statistical evidence of Lyme in many patients with ALS as more than just a coincidence.

Lyme Disease mimics other diseases

ALSLYME

( Image Ref: http://lymediseaseguide.org/wp-content/uploads/2011/07/lyme-disease-treatment-diagnosis.gif)

Does Lyme cause ALS? 

Many ALS patients have tested positively for Lyme disease, but not all Lyme patients develop ALS.  Currently, there is no definitive proof that Lyme disease causes ALS. Although often mistaken for ALS with similar symptoms, Lyme can be treated with antibiotics and other protocols dependent on the severity and progression. A cure for ALS still has not been found, but the Deanna Protocol has been shown to help with quality of life.

This topic continues to be a source of debate among physicians and PALS, with controversy evident on the internet and social media. If you are bitten by a tick, please seek medical attention immediately.

For more information on Lyme Disease: visit http://www.cdc.gov/lyme/

For more information on ALS: http://www.alsa.org/about-als/ 

[1] Ref: http://emedicine.medscape.com/article/330178-overview

[2] Ref: http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm

[3] http://m.nbc12.com/nbc12/db/345738/content/i7HSWfXF/gallery

[4] https://www.washingtonpost.com/opinions/five-myths-about-als/2014/08/22/70007ef2-2842-11e4-86ca-6f03cbd15c1a_story.html

Newest Update on Deanna Protocol

Uncategorized

A recent article was released in March 2017, that examined an earlier study on the Deanna Protocol (DP).  The newest study concluded:

Targeting energy metabolism with the DP supplement as a metabolic therapy produces a change in the global metabolic profile of ALS mice that support the role of the DP for enhanced mitochondrial energy metabolism and prolongs time to paralysis of ALS C. elegans. (1)

For more information on the original article on please view the original article at:  https://link.springer.com/article/10.1007/s11306-017-1183-1

If you need information on how the Deanna Protocol can help you please contact us today for details and assistance.

Getting PALS the Help They Need FASTER!

Blog, disability, Resources, ssdi, , , , ,

ALS is an incurable disease at this time. When a patient and family is dealing with ALS, the last thing they should have to do is wait for financial and medical assistance. Currently, Social Security Disability Insurance (SSDI) has a typical 5-month waiting period for patients with ALS (PALS).

On Thursday, Feb. 16, Congressmen Seth Moulton (D-MA) and Peter King (R-NY) re-introduced The ALS Disability Insurance Access Act, bipartisan legislation they spearheaded to ensure that amyotrophic lateral sclerosis (ALS) patients are provided vital support and benefits in a timelier manner. The legislation would waive the Social Security Disability Insurance (SSDI) five-month waiting period for people living with ALS, commonly referred to as Lou Gehrig’s Disease.[1]

Many PALS are often diagnosed after they experience significant health deterioration and symptoms.  After dealing with the shock of this devastating diagnosis, PALS have to then apply for SSDI, which can be a lengthy and timely process. The ALS Association reports that fifty percent of all PALS succumb to their illness within 16 months of diagnosis.  The waiver of this 5-month waiting period to get sorely needed resources in an expedient and timely manner is critical.  “This legislation is especially important for people with ALS, for whom five months can mean the difference between life and death,” said Barbara Newhouse, President and CEO of The ALS Association. “

The waiver implications go beyond just financial support. Medicare coverage is tied to the onset of the approval and start of SSDI.  The waiting period not only stalls much needed financial assistance to PALS and their families but also medical coverage for very costly care and potential medications.

We need your help to get this very important legislation quickly passed. You can send an e-mail to your members of Congress and personalize it with your story. Please urge your members of Congress to co-sponsor H.R. 1171/S. 379!  You can click here to send your support via the ALS Association website.

To track and monitor the status of this very important legislation you can visit the bill status on this website:   https://www.congress.gov/bill/115th-congress/house-bill/1171

Please see an excerpt of the bill here:

Bill History in the Congressional Record

Page numbers for legislative actions on this bill link to the Congressional Record. Learn more about the History of Bills and Resolutions.

From the Congressional Record, Volume 163 (2017)

——————————————————H.R. 1171–A bill to amend title II of the Social Security Act to     eliminate the five month waiting period for disability insurance     benefits for individuals with amyotrophic lateral sclerosis (ALS);     to the Committee on Ways and Means.  By Mr. MOULTON (for himself, Mr. King of New York, Mr. Bilirakis, Mr. Blumenauer, Mr. Cicilline, Ms. Clark of Massachusetts, Mr. Cohen, Mr. Conyers, Mr. DeFazio, Ms. DelBene, Mr. Engel, Mr. Garamendi, Mr. Heck, Mr. Jones, Mr. Keating, Mr. Kilmer, Ms. Michelle Lujan Grisham of New Mexico, Mr. MacArthur, Mr. McGovern, Mr. Peters, Ms. Pingree, Mr. Pocan, Miss Rice of New York, Mr. Richmond, Mr. Ruppersberger, Mr. Ryan of Ohio, Mr. Schiff, Mr. Sessions, Mr. Tonko, Mr. Walz, and Mr. Swalwell of California), H1300 [16FE]

If you need additional information on the bill or getting help read the original article form the ALS Association here:  http://www.alsa.org/news/media/press-releases/als-disability-insurance-access-act-021617.html

Please get involved today to CURE ALS and help PALS and their families improve their quality of lives.

[1] http://beverly.wickedlocal.com/news/20170220/moulton-king-continue-fight-for-als-patients

The Deanna Protocol® Continues to Impress ALS Patients

Blog, Deanna Protocol, Nutrition, , ,

The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone which is continuing to improve the quality of life for people with ALS.

It was just a few years ago that the Ice Bucket Challenge caught everyone’s eye and raised awareness for ALS, or Lou Gehrig ’s disease.  At the time the Deanna Protocol® was relatively new but it was already helping many ALS patient’s lives.  According to a study by Winning the Fight, which researches “The Deanna Protocol,” a metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in an amyotrophic lateral sclerosis (ALS) mouse model.[1] The benefits of the Deanna Protocol to patients with ALS (PALS) is evident in the anecdotal feedback in recent years.

The Deanna Protocol® Metabolic Plan (also known as the DP™Plan) is a natural, drug-free, and inexpensive metabolic program developed for ALS. Scientific studies have proven that the DP™ Plan significantly slows the progression of ALS and extends life span. The DP™Plan is not an ALS treatment drug like Rilutek/Riluzole. It is a list of substances (AAKG, AKG, GABA, CoQ10, Niacin, and 5HTP) that are already found in the body. However, the amounts found in the body are not nearly enough for those who have ALS, so the DP™Plan provides the body and nerve cells with more of these substances to compensate for what they lack.  It is determined that the substances in the DP™ Plan provide energy to cells that are dying and in doing so keeps them alive.  This is very important because when nerve cells die, they release glutamate which kills the contiguous cells.[2]

In 2014 CBN News wrote that ‘Deanna Protocol’ Makes a Splash in ALS Research’. The study found “mice on The Deanna Protocol had improved neurological scores, increased motor function and most importantly, survived longer than the mice who weren’t on it.”[3]  Since this initial article, the Deanna Protocol has evolved in several major ways, in conjunction with assistance from Simplesa’s commitment to the ALS Community.  Simplesa® was founded in 2013 because it saw a need and had a solution.  ALS patients were having success following the Deanna Protocol, but it was too complex and expensive the way it was distributed. Simplesa® formulated products specifically for these ALS patients to simplify their regimen and lower the cost of the metabolic protocol.

Now all of the products needed to follow the protocol are offered in easy to follow combinations. Due to the improved ease of following the Deanna Protocol with the Simplesa products, the number of people following the protocol has increased. As the number of PALS following the Deanna Protocol has increased, Simplesa has also been able to reduce the cost of the protocol.  Additionally, to add further savings and flexibility to PALS, Simplesa® and Winning the Fight® teamed up to break the Deanna Protocol down into three bundled and more personalized options: Deanna Protocol Core, Plus, and Comprehensive Bundles.

The Deanna Protocol Core Bundle focuses on six essential nutrients of the Deanna Protocol. These nutrients primary support providing energy production to the body through the mitochondria of the cells.  The Plus Bundle builds on the Core Bundle by adding in Liposomal Glutathione, which helps the body push out toxins. It is considered the best antioxidant for the nervous system.  The Comprehensive Bundle builds on the Plus Bundle by adding in the AM & PM Blends. These blends come in two powders, one for the morning and one for the evening, and they contain an additional 20 amino acids that support muscle and nerve health. These combinations are based on the research publication by the NIH on nutrients that should be consumed by people who have ALS.

The affirmative feedback and reports from PALS to Simplesa® on the Deanna Protocol® have been very positive in the years since its inception.  PALS have continued to report improvement in quality of life:

“This product has worked wonders helping to reduce my pain, improve energy, lessen the severity muscle spasms, as well as improve balance and vertigo. I notice a day and night difference within taking my morning dose. I recommend taking the AKG throughout the day, not in lump 3 times a day to improve energy life.”

“My husband has been on the Deanna Protocol Products for two months now. He feels he has more energy and strength. We Would recommend these products!”

For more personal accounts on how the Deanna Protocol is helping PALS please click here.

The Deanna Protocol is not a cure for ALS, but it is a natural metabolic protocol that can help PALS improve their quality of life. To find out more about the Deanna Protocol® please contact Simplesa’s support team for information to see how it can help you or someone you know impacted by ALS.

References

*http://www.medicalnewstoday.com/articles/313919.php

[1] https://www.ncbi.nlm.nih.gov/pubmed/25061944
[2] https://www.winningthefight.org/deanna-protocolreg-metabolic-plan-for-als.html
[3] http://www1.cbn.com/cbnnews/healthscience/2014/August/Deanna-Protocol-Gains-Ground-in-ALS-Research

Simplesa Liposomal B12 the Powerhouse Energy Vitamin

Blog, Nutrition, Resources, , , , , , , , ,

Simplesa B12Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.[1]

What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.

Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.[2]

Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.[3]

Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions.  An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.

As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.[4]

Do I have a B12 deficiency?
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:

·         strange sensations, numbness, or tingling in the hands, legs, or feet

·         difficulty walking (staggering, balance problems)

·         anemia

·         a swollen, inflamed tongue

·         yellowed skin (jaundice)

·         difficulty thinking and reasoning (cognitive difficulties), or memory loss

·         paranoia or hallucinations

·         weakness

·         fatigue

While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.[5]

How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin.  Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.

Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain.  Simplesa Liposomal Vitamin B12   does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.

Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it. [6] Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.

Some of the many benefits of Simplesa Liposomal Vitamin B12:

·         Contributes to normal red blood cell formation

·         Supports the nervous system and mental functions

·         Contributes to a normal, healthy metabolism

·         Is essential for a healthy heart

Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil.  It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.

For more information or to try our new Simplesa Liposomal Vitamin B12 click here.

[1] https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
[2] http://www.health.com/health/gallery/0,,20924065,00.html
[3] http://www.medicalnewstoday.com/articles/219822.php
[4]  http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[5] http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[6] http://www.livestrong.com/article/289321-sublingual-vitamin-b12-vs-injectable-b12/

Holidays and Your Health

Blog, Resources, , , ,

The holidays are frantic and stressful for everyone. If you are disabled or chronically ill, the holidays can present additional stress and potential health risks for you. For the caretaker of a chronically ill person the holiday can add another level of complexity and stress to your already busy life. No one wants to be a Grinch during this time of the year, but it is important to take some extra precautions and preparation to cope.

 

disabledchristmas

Per a recent article in the Huffington Post called “5 Ways the Holidays Are Hard on Those with a Chronic Disease (and 10 Ways to Cope)” the author provides advice on how to deal with the barrage of food, activity and traveling that may occur.

Food: Food is at the heart of nearly all holiday celebrations, and usually steaming mounds of not-so-healthy foods like sugary sweet potatoes. Desserts and sweet drinks are in abundance. For a person with a chronic disease, the variety of foods may be tempting or forbidden, or may just strike terror in our hearts or feelings of being bothered. If you’re staying in a hotel, you might be relegated to eating the in-house free breakfast that doesn’t accommodate your diet.

Traveling: Sitting in a car or on a plane for long periods of time can be the breeding ground for physical pain or, at minimum, provide ample time to worry about one’s disease. Traveling also means a change of routine and a lot of unpredictability and extra stress. For example, flying means I have to go through security at the airport, go through a pat-down while the rest of my family stands by waiting, and explain to multiple personnel what my disease is, what my devices do, and no, they cannot be removed from my body for inspection. Time zone and altitude changes can also be difficult.

Activity: Some holiday celebrations include activities which might be out of your typical routine: skiing, going from house-to-house visiting relatives, power-shopping with your mom on Black Friday. These activities can cause your disease to flare-up in undesirable ways, zapping your energy and bringing down your mood. [1]

For the caregiver who is constantly on call, the holidays just might seem like too much. If you know a caregiver the best thing to do this time of year is help. Perhaps offer to cook, shop, or just spend time with them. Many caregivers get burned out and need a break. Some suggestions for caregivers on how to avoid burnout this time of year are found in a great article by Empowher.com called “3 Steps to Avoiding Caregiver Burnout during the Holidays.”[2] The three biggest things to remember is know the signs of when you need a break, take care of yourself, and remember to ask for help. This is often easier said than done for many caregivers. Resources for help can be found at “The National Family Caregiver Association offers many tips and guides on how to take charge and effectively communicate with caregivers.  Log on to www.thefamilycaregiver.org or call them at 800-896-3650.”[3] The following great tips were found on Everydayhealth.com[4]:

*Eat healthy and try to exercise every day.

*Indulge in an enjoyable activity as often as you can – read a book, work on a hobby, or watch a movie.

*Pamper yourself with a massage or manicure.

*Keep a journal to record your thoughts and feelings.  This can be a good outlet for
frustrations.

* Be in touch with your own body and know when you are becoming ill or run down;
seek medical advice in a timely manner.

*If applicable seek support from your church or synagogue. Besides spiritual support, they often have programs to help caregivers.

*Remember that “laughter is the best medicine.”  Try to find some humor in daily situations.

*Join a support group.  If you can’t leave the house explore Internet options.

If you know a caregiver or chronically ill person, please remember that one of the best things you can offer this holiday season is love, support, time and help.

 

[1] http://www.huffingtonpost.com/rachel-garlinghouse/5-ways-the-holidays-are-hard-on-those-with-a-chronic-disease-and-10-ways-to-cope_b_8435494.html

[2] http://www.empowher.com/caregiving/content/3-steps-avoiding-caregiver-burnout-during-holidays

[3] http://www.everydayhealth.com/columns/lynda-shrager-the-organized-caregiver/how-to-avoid-caregiver-burnout-this-holiday-season/

[4] http://www.everydayhealth.com/columns/lynda-shrager-the-organized-caregiver/how-to-avoid-caregiver-burnout-this-holiday-season/