Medication for Muscle Twitching, Spasticity and Fasciculation Received a Setback

Phase 2 Trial of FLX-787 has stopped, but there is still hope for those suffering from muscle cramps!

About a year ago, the U.S. Food and Drug Administration granted fast track status to Flex Pharma’s treatment for severe muscle cramps in ALS, FLX-787. Flex Pharma has just announced the cease of research and clinical trials of FLX-787.

The Phase 2 trial in the US was evaluating the effectiveness of FLX-787 administered at 30mg three times a day in comparison to placebo. The desired result is an overall reduction in muscle cramps.

Although there were some promising results, there were tolerability issues with the formulation and dosage. Now Flex Pharma is restructuring to lower costs and cutting its workforce by nearly 60 percent. The future is on hold and uncertain with FLX-787.

Other solutions exist. There is still hope to diminish or eliminate some of the musculature symptoms that accompany ALS. The Deanna Protocol by Dr. Vincent Tedone has demonstrated numerous cases of anecdotal evidence that decreases the overall symptoms of spasticity and fasciculation. Not only does it help motor neurons function properly, but has shown promising results in helping the body delay the advancement of the disease by reducing cell death.

In addition, existing ALS clients adhering to the Deanna Protocol, as formulated by Simplesa Nutrition, have reported very good tolerability of the supplements with little to no discomfort or side effects. It would seem that the strategy to help your body heal itself (or at least help it fight a better fight) by providing it with the necessary nutritional supplements is still a worthwhile option.

The moral of the story is to stay in the fight and seek alternative treatments. There are existing and continuously evolving solutions out there to help improve the quality of life of those suffering from ALS and other neurodegenerative diseases.

Sources:
1. ALS News Today: Flex Pharma Stops Phase 2 Trial of FLX-787 to Ease Muscle Cramps in ALS Patients. June 15, 2018 by Jose Marques Lopes, PHD
2. ALS News Today: FLX-787, Which Treats ALS-Associated Muscle Cramps, Wins FDA Fast Track Status. July 26, 2017 by Carolina Henriques
3. Tedone M.D., V.M., Tedone-Gage, D., & Tedone, C. The Deanna Protocol Hope for ALS and Other Neurological Conditions. Tampa: Paradies/ Inspire, LLC, 2015. Print.

The Pros and Cons of the new “Right to Try” Law

On May 30th 2018, the President signed the recently passed Right to Try (RTT) legislation into law. This new law allows patients to receive unapproved medications without FDA notification for up to one year. It also removes the FDA from prohibiting access to an experimental therapy and removes the FDA from advising on dosing, schedule, method of administration or other important safety measures. In short, you’re able to side step the FDA and go directly to the drug manufacturer. You’re basically on your own without the oversight of the FDA. So, Caveat Emptor (buyer beware) and proceed with caution.

Nevertheless, this opens up the door to new possibilities that were simply not available before.

Here’re some of the Pros and Cons as we see them.

PRO’s:

  • Finally, some options. The RTT provides a level of freedom…and hope, that would otherwise be denied patients of terminal diseases.
  • Some of the therapies may prove beneficial and/or point the investigators and drug companies in a better direction.
  • It’s the right of every individual to choose their own destiny.
  • Side stepping Governmental bureaucracy and perhaps accelerating therapies that show promise.
  • Patients can try other drugs, supplements and therapies and report their results to their physicians and drug companies. Now information can flow in more directions.
  • The ALS Association both welcomed and voiced reservations about RTT. The association is aware of and is tracking this new law and will communicate with the ALS community.
  • Since the drugs are experimental and not FDA approved, this MIGHT lower treatment costs, as pharmaceutical companies cannot make a profit on these drugs until they’re FDA approved.
  • Possible access to other treatments and drugs, available outside the US, that have shown promise in other countries.

CON’s:

  • Some medications may not be safe, although they must have passed Phase 1 of clinical trials before patients of RTT can try the drugs.
  • Patients must look out for “bad actors” stepping in now to take advantage of patients vulnerabilities. Check history and reliability of manufacturer.
  • Pharmaceutical companies have very little incentive to provide access or broadly distribute their meds since they cannot make money until the drugs are FDA approved.
  • The RTT law could weaken current patient protection laws enforced by the FDA.
  • The reality is that many experimental drugs have limited access and availability anyway.
  • The RTT law may work as a pressure release valve and may reduce pressure on the FDA to speed up approval of Phase 1, 2 and 3 drugs in the pipeline.
  • Patient has little to no legal safeguards in case therapy produces more harm than good.

All in all, we think that the net effect of the new RTT law will be a positive one. This law opens up the conversation about the FDA’s unjustifiably slow and expensive process and provides the patient with some control over their destiny. That being said, patients need to be careful not to make a bad situation worse and should continue to consult with their physicians before venturing into unexplored territories.

Sources:

Cannabinoids to Treat ALS?

And OTHER Neurodegenerative Conditions

Let’s be honest, when you hear or read the word Cannabis, Hemp, CBD, Marijuana, what comes to mind? Some people giggle, others cringe, some get offended. Now, there’s an increasing group of ex-sceptics, including reputable researchers, who contemplate and study the POSSIBILITIES.

Understanding how marijuana and the brain’s own natural cannabinoid system works is helping researchers design new medicines.

Cannabinoid expert Daniele Piomelli, PhD, of the University of California in Irvine. Says, “It’s believed that the controlled therapies that come out of this research might provide select benefits to patients while avoiding some of the unwanted effects seen with the drug.”

Research from California Pacific Medical Center in San Francisco points to the promise of marijuana-like treatments for those with the fatal brain disorder ALS, also known as Lou Gehrig’s disease.

We all know new treatments for ALS are desperately needed.

ALS wreaks its havoc by harming nerve cells and patients experience progressive muscle weakness that can hinder movement, speech, even swallowing and breathing. The only FDA approved drug for ALS, Riluzole (marketed as Rilutek), extends life on average by about two months,” says Abood. “Evidence from our study suggests that a marijuana-based therapy could create a much greater effect, perhaps extending life by three years or more.”

In the study, ALS mouse models were given either the marijuana compound THC, the marijuana compound cannabidiol, cannabidiol plus THC, or a placebo daily following the onset of disease signs. The researchers measured disease progression by testing how long the mice could stand on a slowly rotating rod. The more severe their nerve cell degeneration, the less time the mice can balance on the rod. In addition, two conditions of ALS, the loss of movement ability and survival time, were analyzed using a mathematical model.

“We found that treatment with THC delayed disease progression by seven days and extended survival by six days in the mouse model,” says Abood. “This corresponds to three years in human terms.”

Another part of the study determined that the marijuana compounds create their benefits by reducing two molecular processes, known as oxidative stress and glutamate excitotoxicity. These processes have been implicated in ALS and are thought to harm nerve cells.

Other Neurodegenerative conditions

Another animal study also indicates that a marijuana-like compound can protect brain cells from the damage produced by the disorder Parkinson’s disease.

“For the first time, our research shows the neuroprotective value of marijuana-like compounds in a well-established animal model of Parkinson’s disease,” says study author Andrea Giuffrida, PhD, of the University of Texas Health Science Center in San Antonio.

As a next step, the researchers are testing whether the marijuana-like compounds have neuroprotective value when brain cell damage is already present and whether they can prevent the progression of brain cell loss. “Learning more about the mechanisms by which marijuana-like compounds may slow down or prevent neurodegeneration in Parkinson’s disease may translate into new pharmacological treatments that could fight this disorder in its earliest stages,” adds Giuffrida.

If you or a loved one could have a better quality of life through your ALS ordeal, would you say yes to Cannabis?

Sources: Science Daily, ALS News Today, Leafly

20 things to know regarding Pharmaceutical vs. Nutraceutical protocols for ALS!

Radicava® vs Deanna Protocol®

To understand what the differences between Pharmaceutical and Nutraceutical are, we should begin with their definitions:

phar·ma·ceu·ti·cal

Adjective

  1. Relating to medicinal drugs, or their preparation, use, or sale.

Noun

  1. a compound manufactured for use as a medicinal drug.

nu·tra·ceu·ti·cal

Noun

Plural noun: nutraceuticals 

a food containing health-giving additives and having medicinal benefit.

Now, let’s compare the new drug approved by the FDA Radicava® vs The Natural alternative for a better quality of life, the Deanna Protocol®.

  • 10 Things to Know About the New ALS Drug Radicava®
  1. It is a Pharmaceutical drug.
  2. The drug underwent a phase 3 clinical trial in Japan and South Korea where 137 ALS patients were given either Radicava® or a placebo. The group given Radicava® experienced a 33 percent reduction in the decline of their physical abilities compared to the placebo group.
  3. Radicava® works by reducing the oxidative stress in the body. People with ALS have high levels of oxidative stress.
  4. Radicava® is administered via intravenous infusions. Initially, patients have a daily infusion for two weeks and then have two weeks’ rest. After that, they need to have 10 consecutive daily infusions followed by two weeks of rest.
  5. Each infusion takes around an hour to complete.
  6. The dosage of each infusion is 60 mg.
  7. The cost of each Radicava® infusion is about $1,000 and it’s reported that the treatment costs about $146,000 annually.
  8. Radicava® should be available to ALS patients in the U.S. by August.
  9. The most common side effects associated with the drug are headaches, bruising and gait problems.
  10. Radicava® infusion contains sodium bisulfite which is known to cause both mild and severe allergic reactions in some people (particularly those with asthma).
  • 10 Things to Know About the Deanna Protocol®
  1. It is a naturally derived Nutraceutical program.
  2. Developed by Doctor Vincent Tedone, a retired physician (Orthopedic Surgeon), for his daughter Deanna who was diagnosed with ALS at the age of 30 in 2007.
  3. The Deanna Protocol® has undergone double blind clinical trials at the University of South Florida in mice models. The Deanna Protocol® has over 1,500 anecdotal case studies from patients with ALS.
  4. The Deanna Protocol® is a blend of nutritional powders and liquids that contain powerful antioxidants and amino acids essential to assist your body in its natural efforts to fight neurodegenerative damage. People suffering from other neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, have also reported improvements.
  5. It is taken in the morning, in the afternoon and at night as part of your regular, at home, breakfast, lunch and dinner routine. No need to go to the clinic.
  6. The Protocol is the same for everyone but the dosages might vary, depending on the person and what their specific needs are. The most common side effect is an upset stomach usually reported during the initial days as the body adjusts to the protocol.
  7. The cost of the Deanna Protocol® starts at $219.99 for the Core Bundle #1. The next most inclusive package is the Plus Bundle #1 at $249.99. And our most inclusive bundle is the Comprehensive Bundle #1 at $349.99. Above prices are for a 1 month supply and include easy-to-follow, step-by-step instructions and an actual human to answer your questions and provide you with the support you need.
  8. Not sure? At Simplesa’s website there’re 330+ reviews with 4.5 stars from verified and satisfied buyers at simplesanutrition.com or call 1-888-578-5528.
  9. Deanna Protocol® has been in the market for almost 4 years. The popularity of the protocol and the positive reports from the clients, speak for themselves.
  10. The freshness of the products used in the Deanna Protocol is guaranteed, these products are naturally derived and are manufactured in a facility that follows strict Current Good Manufacturing Practice (cGMP) (Enforced by the FDA) and is UL (Underwriters Laboratories) certified.

 This Blog is for educational purposes. We hope that the above information helps you make the right decisions to address your neuro-degenerative concerns. And as always consult your physician.

 If you liked this article, please share with others
that could benefit from this information.
Remember Sharing is Caring!

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any diseases.

Sources:
alsnewstoday.com
winningthefight.org
simplesanutrition.com/deanna-protocol/

 

B12 the Powerhouse Energy Vitamin – Try Simplesa Liposomal

Simplesa B12Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.[1]

What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.

Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.[2]

Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.[3]

Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions.  An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.

As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.[4]

Do I have a B12 deficiency?
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:

·         strange sensations, numbness, or tingling in the hands, legs, or feet

·         difficulty walking (staggering, balance problems)

·         anemia

·         a swollen, inflamed tongue

·         yellowed skin (jaundice)

·         difficulty thinking and reasoning (cognitive difficulties), or memory loss

·         paranoia or hallucinations

·         weakness

·         fatigue

While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.[5]

How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin.  Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.

Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain.  Simplesa Liposomal Vitamin B12   does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.

Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it. [6] Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.

Some of the many benefits of Simplesa Liposomal Vitamin B12:

·         Contributes to normal red blood cell formation

·         Supports the nervous system and mental functions

·         Contributes to a normal, healthy metabolism

·         Is essential for a healthy heart

Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil.  It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.

For more information or to try our new Simplesa Liposomal Vitamin B12 click here.

[1] https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
[2] http://www.health.com/health/gallery/0,,20924065,00.html
[3] http://www.medicalnewstoday.com/articles/219822.php
[4]  http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[5] http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[6] http://www.livestrong.com/article/289321-sublingual-vitamin-b12-vs-injectable-b12/

Lunasin and Its Benefits

Lunasin has been getting a lot of press, research and attention for benefiting a variety of health conditions. It is important to understand the science behind Lunasin, and how it can help your body.

Lunasin is natural, and found in soy, barley, and rye.  It is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus.

Proteins and peptides are fundamental components of cells that carry out important biological functions. Proteins give cells their shape, for example, and they respond to signals transmitted from the extracellular environment. Certain types of peptides play key roles in regulating the activities of other molecules. Structurally, proteins and peptides are very similar, being made up of chains of amino acids that are held together by peptide bonds (also called amide bonds).

So, what distinguishes a peptide from a protein?

The basic distinguishing factors are size and structure. Peptides are smaller than proteins. Traditionally, peptides are defined as molecules that consist of between 2 and 50 amino acids, whereas proteins are made up of 50 or more amino acids. In addition, peptides tend to be less well defined in structure than proteins, which can adopt complex conformations known as secondary, tertiary, and quaternary structures. [1]

Lunasin is a “bioactive” peptide which means it is a compound that influences living things and their core elements – like tissue and cells. Bioactive compounds have been shown via research and studies to have an influence on health. Areas of Lunasin research have focused on cancer, cholesterol, cardiovascular, inflammation, skin health and anti-aging.  Let’s examine these studies and how the science supports the benefits of Lunasin on your health and well-being.

Cancer

For over a decade research has shown “Lunasin as a cancer-preventive soy peptide.”[2] Memorial Sloan Kettering Cancer Center indicated that:

Studies in animals suggest that soy can prevent or reduce bone loss. In laboratory studies, iso- flavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. Animal studies showed that genistein, one of the isoflavones, may interfere with tamoxifen that is used for breast cancer. But a new study showed that soy foods can benefit women with breast cancer. Patients should consult their physicians about use of soy supplements.[3]

Skin Health

In 2017 a study stated that “The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells” and concluded that “Our studies suggest that Lunasin represents a unique anticancer agent that could be developed to help prevent metastasis and patient relapse by reducing the activity of CICs which are known to be resistant to current chemotherapies.”[4]

Cholesterol & Cardiovascular Health

The 2016 study “Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease” published by American Heart Association, Inc. found that:

Soy protein has an approved FDA health claim for reducing LDL cholesterol and CVD risk but the active component and mechanism of action are unknown. They tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol.

Using a lunasin bioactivity assay, we were able to produce a lunasin-enriched soy extract (LSE) containing 100-200-fold more bioactive lunasin than soy protein isolates. To test the in vivo efficacy of LSE, we conducted a food supplementation experiment on five pigs that have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE every day for eight weeks. Blood draws and lipid panel testing were done at -2w (before casein diet), 0w (2 weeks casein), 4w (4w casein + 250 mg LES) and 8w (8w casein + 250 mg LES). Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in case in diet reduced LDL cholesterol by 8.6% and 6.4% after 4 and 8 weeks of treatment, respectively. These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.[5]

Inflammation

Inflammation has an impact on all areas of health and well-being.

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic diseases such as cancer. Lunasin is a novel peptide that demonstrates potential anticancer activity against mammalian cancer cell lines and may play a role in inflammation. In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced.[6]

Although inflammation is linked in the public mind with chronic health problems such as heart disease, diabetes, and rheumatoid arthritis, de Mejia said it also plays a role in the development of cancer. “We know that chronic inflammation is associated with an increased risk of malignancies, that it’s a critical factor in tumor progression,” she said. “And we can see that daily consumption of lunasin-rich soy protein may help to reduce chronic inflammation.[7]

Obesity

A study in 2017 examined the relationship between inflammation and obesity. The study was called “Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production”.

This study indicated that lunasin is not only effective against inflammatory response of RAW264.7 macrophages, but also highlights this suppressive property on 3T3-L1 adipocytes, and disrupts the crosstalk between macrophages and adipocytes, particularly by inhibiting secretion of pro-inflammatory mediators, might benefit to ameliorate obesity-induced inflammatory diseases.[8]

Anti-Aging

Lunasin has been shown to help with anti-aging. Epigenetics shows the relationship of Lunasin to aging. Epigenetics is the study of long-term changes in chromosomes that don’t involve alterations in the genetic code.

But perhaps the most exciting area of aging epigenetics is the recent notion of an epigenetic clock, called Horvath’s clock, after its discoverer. The gist of it is that there is a strong association between the amount of genome-wide methylation and mortality. A lot of the genome is methylated when we are young but methylation is reduced in a constant clock-like way as we age. Methylation, recall, tends to silence genes. With age, it appears, an increasing number of genes that should be silenced are not, rendering us more susceptible to all manner of ailments. From reading the amount of methylation in the epigenome, scientists can predict an individual’s age with impressive accuracy.[9]

If you can utilize Lunasin to regulate or reset epigenetic implications of aging, then some studies believe we can reverse it.  One such study, examined this aspect of utilizing Lunasin for anti-aging. “Histone Modifications and Epigenetic Regulation Could Hold the Key to Reversing Aging” found that:

Results from a recent study conducted by researchers at the University of Pennsylvania show that yeast could help advance our progress in extending life in human cells. The team of researchers included Shelley Berger, PhD, professor in Cell & Developmental Biology and Biology & Genetics departments at the Perelman School of Medicine, Weiwei Dang, PhD, assistant professor at Baylor College of Medicine and former postdoc fellow at Penn, and Payel Sen, PhD, a current postdoc fellow in Berger’s lab. The study was published in Genes & Development and focused on how a certain epigenetic histone modification could extend yeast’s lifespan.

“Researchers have just started to appreciate how these epigenetic histone modifications may be playing essential roles in determining lifespan,” said Berger. She has conducted studies on epigenetic marks for more than 20 years and was one of the first to identify histone modifications that are altered during aging and directly impact longevity.

Dang explained that their study pinpointed a type of abnormal transcription that is significantly increased in older cells and, if reduced, can lengthen lifespan in yeast. He started the research when he was working in Berger’s lab.

He explained that “this longevity effect is mediated through an evolutionarily conserved chemical modification on histones [and] this is the first demonstration that such a mechanism exists to regulate aging.”

Although measuring aging in yeast is quite different from measuring human aging, Sen noted that using a budding yeast single-cell organism model turned out to be surprisingly powerful in their study of aging and epigenetic regulation.[10]

The research, science and benefits of Lunasin are clearly seen in these and many other scientific studies.

lunacell

 

 

Simplesa LunaCell™ is the most advanced Lunasin supplement on the market today. LunaCell has more than twice the concentration of bioavailable Lunasin than any other product available.  If you understand the science, then the choice is clear – choose LunaCell™!!

 

 

 

[1] https://www.britannica.com/demystified/what-is-the-difference-between-a-peptide-and-a-protein

[2] https://www.ncbi.nlm.nih.gov/pubmed/15730231

[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/soy

[4] https://www.ncbi.nlm.nih.gov/pubmed/28424421

[5] http://circ.ahajournals.org/content/126/Suppl_21/A10693

[6] http://www.sciencedirect.com/science/article/pii/S0196978109003416

[7] https://www.sciencedaily.com/releases/2009/12/091202153946.htm

[8] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171969

[9] http://goop.com/understanding-epigenetics-and-what-it-means-for-aging-cancer-and-obesity/

[10] https://www.whatisepigenetics.com/histone-modifications-and-epigenetic-regulation-could-hold-the-key-to-reversing-aging/

In Support of Parkland, Florida

As you may be aware, Simplesa is located in Coral Springs, Florida, the city adjacent to Parkland where the horrific school shooting took place earlier this week. Our thoughts and prayers go out to all those affected by the recent events. In support of our local community, Simplesa will be donating a portion of its proceeds for the rest of February to the victims and support efforts for those tragically affected. We invite you to join us in this cause.

simplesaparkland
In Support of Parkland, FL
For those customers looking to stock up on products before the end of the month, we are offering the following discounts:

Spend $200 during the rest of February and
get $15.00 OFF
use coupon code:
HEARTS4PARKLAND15

Spend $300 during the rest of February and
get $30.00 OFF
use coupon code:
HEARTS4PARKLAND30

Spend $500 during the rest of February and
get $65.00 OFF
use coupon code:
HEARTS4PARKLAND65

Spend $700 during the rest of February and
get $100.00 OFF
use coupon code:
HEARTS4PARKLAND100

parklandpromo

INTRODUCING OUR 2018 LOYALTY PROGRAM

We are pleased to launch our new 2018 Simplesa Loyalty Program. This program will enable you to earn rewards on your Simplesa purchases that can be used for discounts on future orders. Importantly, there is no expiration date on the points you earn. Get points for all your orders, and sometimes we’ll offer special opportunities to earn bonus points. You can keep track of your points by logging into your Simplesa account. Thank you for being a valued customer.

 

Simplesa Rewards Overview

SimplesaLoyalty

175 Points = $5 Voucher


330 Points = $10 Voucher


600 Points = $15 Voucher


900 Points = $25 Voucher


1,100 Points = $35 Voucher


1,500 Points = $50 Voucher


2,100 Points = $75 Voucher



2,600 Points = $100 Voucher


3,750 Points = $150 Voucher


4,000 Points = $200 Voucher


 

Start Earning Points

FREQUENTLY ASKED QUESTIONS
How do I enroll?
To enroll, you just have to create an account at SimplesaNutrition.com
Do I have to enroll if I am already a Customer?
We have already enrolled everyone with an active account and even rewarded you with 50 points to start the New Year.
When does the program begin?
The program begins January 1st, 2018

 

 

 

 

 

 

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Tips for Caregivers

 caregivingCaregiving – It’s one of the hardest, physically and emotionally draining roles anyone can undertake.  In a 2015 survey from AARP and the National Alliance of Caregiving it was found that a third of all Americans are caregivers, providing care to someone who is disabled, ill or elderly.  The same study found that almost 80% of these caregivers stated they needed help.[1] Caregivers can be family members or friends. Many caregivers have jobs, families, and the additional responsibility of the minute to minute needs of the person to whom they are providing care 24/7.  It is not just driving to doctor visits or making meals. Many caregivers are providing nursing care (maintaining Stomas, catheters, or feeding tubes), often without the training or previous experience to do so. Caregivers learn quickly as the lives and well-being of someone they love relies on them. Perhaps the person being cared for is not a good patient, or does not remember you, or has tremendous guilt in being ill or helpless. These are all potential circumstances that many caregivers have to face every day. It’s one of the experiences in life that unless you have done it – you won’t quite understand the demands or the challenges.

Tips for Caregiver:

The first rule of taking care of others: take care of yourself first. Caregiving can be a rewarding experience, but it is also physically and emotionally demanding. The stress of dealing with caregiving responsibilities leads to a higher risk of health issues among the nation’s 90 million family caregivers. So as a family caregiver, remember to pay attention to your own physical and mental wellness, and get proper rest and nutrition. Only by taking care of yourself can you be strong enough to take care of your loved one. You really do need to “take care to give care!”

  • Caregiving can be a stressful job. Most family caregivers say they feel stressed providing care for a loved one. With all of their caregiving responsibilities – from managing medications to arranging doctor appointments to planning meals – caregivers too often put themselves last.
  • The stress of caregiving impacts your own health. One out of five caregivers admit they have sacrificed their own physical health while caring for a loved one. Due to stress, caregivers have a disproportionate number of health and emotional problems. They are twice as likely to suffer depression and are at increased risk for many other chronic conditions.
  • Proper nutrition helps promote good health. Ensuring that you are getting proper nutrition is key to help maintain your strength, energy and stamina, as well as strengthening your immune system. Maintaining a healthy diet is one of the most powerful things you can do to take care of yourself and keep a positive attitude overall.
  • Ensuring good nutrition for your loved one helps make care easier. As many as half of all older adults are at risk for malnutrition. Good nutrition can help maintain muscle health, support recovery, and reduce risk for re-hospitalization – which may help make your care of a loved one easier.
  • Remember: “Rest. Recharge. Respite.” People think of respite as a luxury, but considering caregivers’ higher risk for health issues from chronic stress, those risks can be a lot costlier than some time away to recharge. The chance to take a breather, the opportunity to re-energize, is vital in order for you to be as good a caregiver tomorrow as you were today.[2]

What is Respite?

According to the Lifespan Respite Care Act (PL 109-442), Lifespan Respite is defined as ‘coordinated systems of community-based respite for family caregivers of children or adults regardless of special need.’  For more information, on Respite please visit: https://archrespite.org/index.php

Tips for Others:

As a caregiver your world at times feels like it’s in chaos and out of your control.  Interacting with other people can often be tiresome and difficult as you simply feel too overwhelmed to participate in social settings. Other people often want to help and support you, but struggle with what they can say and do to help.  We have compiled some great suggestions for what to say or not to say to caregivers.  Please feel free to send suggestions we have not mentioned in this blog. Interesting enough, there is some overlap on the advice on what best to say or not to say to caregivers. Bottom line:  speak from the heart and be supportive of their needs.

12 Things You Should Say to a Family Caregiver By Becky Benishek

Keep in mind many caregivers won’t ask for help, so the best way to help someone is to do things for them that they may not have the time, money, or mental energy to do for themselves. Social settings and activities may at times be too draining, or the fear of being a “bummer” or not in “the best mood” can often cause many caregivers to go into recluse mode.

A Dozen Things You Should Never Say to A Caregiver by Ann Brenoff

There is assistance and resources to help caregivers.  Many times a caregiver is so consumed in the day to day tasks of caregiving they don’t have the bandwidth to research tools or support.  One such resource is geared to caregivers of Veterans.  Per the Veteran Benefits: Caregiver Programs and Services on Military.com website:

On May 5, 2010, the Caregivers and Veterans Omnibus Health Services Act of 2010 was signed into law. Title I of the Act will allow VA to provide unprecedented benefits to eligible Caregivers (a parent, spouse, child, step-family member, extended family member, or an individual who lives with the Veteran, but is not a family member) who support the Veterans who have given so much for this Nation. The law distinguishes between Veterans who incurred or aggravated a serious injury in the line of duty on or after Sept. 11, 2001 (post-9/11 Veterans), and those Veterans whose injuries were incurred prior to Sept. 11, 2001 (pre-9/11 Veterans).

Please visit the VA’s caregiver page for more information, and to apply for these services.

 Caregivers Toolbox:

http://caregiveraction.org/family-caregiver-toolbox

http://www.caregiving.org/resources/

http://www.rosalynncarter.org/caregiver_resources/

https://www.medicare.gov/campaigns/caregiver/caregiver.html

http://www.aarp.org/home-family/caregiving/?cmp=RDRCT-CRGNG_APR12_012

http://www.easterseals.com/explore-resources/for-caregivers/understanding-aging-and-caregiving.html

Footnotes:

[1] http://www.huffingtonpost.com/entry/a-dozen-things-you-should-never-say-to-a-caregiver_us_5621409fe4b08589ef474317

[2] http://caregiveraction.org/national-family-caregivers-month-theme/

Complementary Regimes of Lunasin and Deanna Protocol® for Veterans

VeteVrans Day is an important time to raise awareness of the ongoing health, physical and mental issues encountered by veterans during and after service. Recent studies show that veterans have a 60 percent higher risk of getting ALS than the general population.

“We don’t know what about service could lead to increased risk of the disease in veterans,” said Patrick Wildman, vice president of public policy for the ALS Association. “It could be a variety of factors from head trauma and excessive physical activity to exposures. It also could be a combination of a genetic predisposition with an environmental trigger.” The Mayo Clinic surmises that reasons for the connection “may include exposure to certain metals or chemicals, traumatic injuries, viral infections and intense exertion” but says that “exactly what about military service may trigger the development of ALS is uncertain.”[1]

These statistics are so staggering and alarming that Veterans Affairs has made ALS automatically service connected.

It doesn’t matter in which era the veterans served. From World War II through the Gulf War and even in peacetime, multiple studies show that the rate at which vets develop the condition is still twice as high as non-vets. In fact, the evidence is so convincing the Department of Veterans Affairs has assumed since 2008 that a veteran’s ALS is automatically service-connected.[2]

Finding ways to combat the onset or slow the progression of ALS is critical for patients with ALS (PALS) until a cure is found. Improving the quality of life for all those with ALS is a focus for Simplesa®.  The Deanna Protocol® (DP) is an all-natural metabolic program that works to support mitochondria dysfunction with energy production and counteracting oxidative stress. DP helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[3] Lunasin was the first dietary compound with an identified epigenetic mechanism of action. PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals. Research indicates that veterans with ALS and/or similar neurological issues have damage that is receptive to epigenetic therapies like Lunasin.

Dr. Richard Bedlack, Professor and Director of the ALS Clinic at Duke University, is conducting a study on Lunasin in 50 ALS patients. The study is a first of a kind clinical study that is investigating the efficacy of Lunasin in the support of ALS. It’s the fastest enrollment study ever conducted in their history. The clinical trial is based on Mike McDuff, an ALS patient who showed a remarkable reversal after taking bioactive Lunasin. He gained back his weight, went off his feeding tube and could talk again. Not all people will have the same results, but it greatly improved Mike’s quality of life.[4]

 

lunacell

Simplesa® is committed to helping veterans. They have a dedicated customer support staff of veterans to assist with questions about Simplesa’s Lunasin product called LunaCell™ and the Deanna Protocol®.

Simplesa® has always been steadfast to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. These two complementary regimes provide additional choices for PALS to help improve their quality of life.

For additional information on available veteran resources contact: http://www.pva.org

Sources:

[1] http://www.cnn.com/2015/11/11/health/als-and-military-veterans/index.html

[2] www.wearethemighty.com/veterans/military-veterans-are-twice-as-likely-to-get-als-and-no-one-knows-why

[3] www.mndassociation.org/wp-content/uploads/FINAL-WIP-booklet-Dublin-081116.docx

[4] lunasin.com/studies

 

Related Links

Deanna Protocol® Program for ALS

LunaCell

Related Video

http://www.youtube.com/watch?v=tOKoesaCh7M

Simplesa® is now offering the Deanna Protocol® and Lunasin to ALS Patients

Simplesa, a nutrition company established in 2013 after the amyotrophic lateral sclerosis (ALS) community showed its support for a metabolic supplement treatment called the Deanna Protocol (DP), has expanded its products for the Deanna Protocol with the addition of LunaCell™ for consumers.

Patients with ALS (PALS) have been following the Deanna Protocol (DP) since it was first released in 2011. The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone, a retired physician whose daughter, Deanna, was diagnosed with ALS. The Deanna Protocol works to support mitochondria dysfunction with energy production and the counteracting oxidative stress. The Deanna Protocol (DP) helps improve the quality of life for people with ALS. Patients who consistently follow the plan have reported an improvement in energy production, reduction in muscle twitching and cramping, and improved coordination, balance, and limberness.

lunacellLunasin first caught the attention of physicians and the ALS community when Mike McDuff, who was diagnosed with ALS, took the nutrient in 2012 and had a remarkable recovery. Therefore, Lunasin, a soy peptide that may alter histone acetylation, has been associated with ALS reversal.[1] Lunasin was the first dietary compound with an identified epigenetic mechanism of action.  PALS often have elevated levels of free radicals. Lunasin is significant to the ALS population as multiple studies show Lunasin helps reduce free radical production while also scavenging free radicals.    Since that time, Lunasin has caught the attention of many trying to cure and/or treat ALS.  Among those interested in Lunasin and ALS is Dr. Richard Bedlack, Director of the ALS Clinic at Duke University. He started the first of its kind study on Lunasin with reporting conducted through a patient network and real-time research platform called Patients Like Me.

As with the Deanna Protocol, Simplesa saw the potential to help PALS with Lunasin.  Simplesa® recently released its Lunasin product, LunaCell™, which consists of a superior bioavailable form of Lunasin and is priced relatively lower than other Lunasin products. This formulation allows patients to take less capsules and quickly absorb more Lunasin into their system.

Feedback from verified consumers of the products has been very positive:

It seems impossible but after two days my dad muscle movement on leg that is useless for more than a year. – Andrej

 

I only take half of the capsules and it costs half as much as other Lunasin I took. Thank you. – Pedro O.

Simplesa® has always been committed to meeting the unmet needs of its consumers, and they quickly saw the benefit to PALS to provide more options with the Deanna Protocol® products and LunaCell™. This new program is opening doors for additional choices for PALS to try both complimentary regimes and improve their quality of life.

Sources:

  1. Oxidative Stress and Radivcava: 

https://alsnewstoday.com/2017/08/03/nine-things-to-know-about-the-new-als-drug-radicava/

  1. Oxidative Stress and Lunasin:

https://core.ac.uk/download/pdf/3616328.pdf

  1. Oxidative Stress and Deanna protocol: 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103526

https://www.researchgate.net/publication/272828777_ALS_Untangled_No_20_the_Deanna_protocol

[1]www.mndassociation.org%2Fwp-content%2Fuploads%2FFINAL-WIP-booklet-Dublin-081116.docx&usg=AOvVaw0QgHpgvjCAB2Dae8-77Ins

The Science Behind Lunasin and Its Benefits

Lunasin has been getting a lot of press, research and attention for benefiting a variety of health conditions. It is important to understand the science behind Lunasin, and how it can help your body.

Lunasin is natural, and found in soy, barley, and rye.  It is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus.

Proteins and peptides are fundamental components of cells that carry out important biological functions. Proteins give cells their shape, for example, and they respond to signals transmitted from the extracellular environment. Certain types of peptides play key roles in regulating the activities of other molecules. Structurally, proteins and peptides are very similar, being made up of chains of amino acids that are held together by peptide bonds (also called amide bonds).

So, what distinguishes a peptide from a protein?

The basic distinguishing factors are size and structure. Peptides are smaller than proteins. Traditionally, peptides are defined as molecules that consist of between 2 and 50 amino acids, whereas proteins are made up of 50 or more amino acids. In addition, peptides tend to be less well defined in structure than proteins, which can adopt complex conformations known as secondary, tertiary, and quaternary structures. [1]

Lunasin is a “bioactive” peptide which means it is a compound that influences living things and their core elements – like tissue and cells. Bioactive compounds have been shown via research and studies to have an influence on health. Areas of Lunasin research have focused on cancer, cholesterol, cardiovascular, inflammation, skin health and anti-aging.  Let’s examine these studies and how the science supports the benefits of Lunasin on your health and well-being.

Cancer

For over a decade research has shown “Lunasin as a cancer-preventive soy peptide.”[2] Memorial Sloan Kettering Cancer Center indicated that:

Studies in animals suggest that soy can prevent or reduce bone loss. In laboratory studies, iso- flavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. Animal studies showed that genistein, one of the isoflavones, may interfere with tamoxifen that is used for breast cancer. But a new study showed that soy foods can benefit women with breast cancer. Patients should consult their physicians about use of soy supplements.[3]

Skin Health

In 2017 a study stated that “The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells” and concluded that “Our studies suggest that Lunasin represents a unique anticancer agent that could be developed to help prevent metastasis and patient relapse by reducing the activity of CICs which are known to be resistant to current chemotherapies.”[4]

Cholesterol & Cardiovascular Health

The 2016 study “Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease” published by American Heart Association, Inc. found that:

Soy protein has an approved FDA health claim for reducing LDL cholesterol and CVD risk but the active component and mechanism of action are unknown. They tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol.

Using a lunasin bioactivity assay, we were able to produce a lunasin-enriched soy extract (LSE) containing 100-200-fold more bioactive lunasin than soy protein isolates. To test the in vivo efficacy of LSE, we conducted a food supplementation experiment on five pigs that have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE every day for eight weeks. Blood draws and lipid panel testing were done at -2w (before casein diet), 0w (2 weeks casein), 4w (4w casein + 250 mg LES) and 8w (8w casein + 250 mg LES). Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in case in diet reduced LDL cholesterol by 8.6% and 6.4% after 4 and 8 weeks of treatment, respectively. These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.[5]

Inflammation

Inflammation has an impact on all areas of health and well-being.

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic diseases such as cancer. Lunasin is a novel peptide that demonstrates potential anticancer activity against mammalian cancer cell lines and may play a role in inflammation. In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced.[6]

Although inflammation is linked in the public mind with chronic health problems such as heart disease, diabetes, and rheumatoid arthritis, de Mejia said it also plays a role in the development of cancer. “We know that chronic inflammation is associated with an increased risk of malignancies, that it’s a critical factor in tumor progression,” she said. “And we can see that daily consumption of lunasin-rich soy protein may help to reduce chronic inflammation.[7]

Obesity

A study in 2017 examined the relationship between inflammation and obesity. The study was called “Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production”.

This study indicated that lunasin is not only effective against inflammatory response of RAW264.7 macrophages, but also highlights this suppressive property on 3T3-L1 adipocytes, and disrupts the crosstalk between macrophages and adipocytes, particularly by inhibiting secretion of pro-inflammatory mediators, might benefit to ameliorate obesity-induced inflammatory diseases.[8]

Anti-Aging

Lunasin has been shown to help with anti-aging. Epigenetics shows the relationship of Lunasin to aging. Epigenetics is the study of long-term changes in chromosomes that don’t involve alterations in the genetic code.

But perhaps the most exciting area of aging epigenetics is the recent notion of an epigenetic clock, called Horvath’s clock, after its discoverer. The gist of it is that there is a strong association between the amount of genome-wide methylation and mortality. A lot of the genome is methylated when we are young but methylation is reduced in a constant clock-like way as we age. Methylation, recall, tends to silence genes. With age, it appears, an increasing number of genes that should be silenced are not, rendering us more susceptible to all manner of ailments. From reading the amount of methylation in the epigenome, scientists can predict an individual’s age with impressive accuracy.[9]

If you can utilize Lunasin to regulate or reset epigenetic implications of aging, then some studies believe we can reverse it.  One such study, examined this aspect of utilizing Lunasin for anti-aging. “Histone Modifications and Epigenetic Regulation Could Hold the Key to Reversing Aging” found that:

Results from a recent study conducted by researchers at the University of Pennsylvania show that yeast could help advance our progress in extending life in human cells. The team of researchers included Shelley Berger, PhD, professor in Cell & Developmental Biology and Biology & Genetics departments at the Perelman School of Medicine, Weiwei Dang, PhD, assistant professor at Baylor College of Medicine and former postdoc fellow at Penn, and Payel Sen, PhD, a current postdoc fellow in Berger’s lab. The study was published in Genes & Development and focused on how a certain epigenetic histone modification could extend yeast’s lifespan.

“Researchers have just started to appreciate how these epigenetic histone modifications may be playing essential roles in determining lifespan,” said Berger. She has conducted studies on epigenetic marks for more than 20 years and was one of the first to identify histone modifications that are altered during aging and directly impact longevity.

Dang explained that their study pinpointed a type of abnormal transcription that is significantly increased in older cells and, if reduced, can lengthen lifespan in yeast. He started the research when he was working in Berger’s lab.

He explained that “this longevity effect is mediated through an evolutionarily conserved chemical modification on histones [and] this is the first demonstration that such a mechanism exists to regulate aging.”

Although measuring aging in yeast is quite different from measuring human aging, Sen noted that using a budding yeast single-cell organism model turned out to be surprisingly powerful in their study of aging and epigenetic regulation.[10]

The research, science and benefits of Lunasin are clearly seen in these and many other scientific studies.

lunacell

 

 

Simplesa LunaCell™ is the most advanced Lunasin supplement on the market today. LunaCell has more than twice the concentration of bioavailable Lunasin than any other product available.  If you understand the science, then the choice is clear – choose LunaCell™!!

 

 

 

[1] https://www.britannica.com/demystified/what-is-the-difference-between-a-peptide-and-a-protein

[2] https://www.ncbi.nlm.nih.gov/pubmed/15730231

[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/soy

[4] https://www.ncbi.nlm.nih.gov/pubmed/28424421

[5] http://circ.ahajournals.org/content/126/Suppl_21/A10693

[6] http://www.sciencedirect.com/science/article/pii/S0196978109003416

[7] https://www.sciencedaily.com/releases/2009/12/091202153946.htm

[8] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171969

[9] http://goop.com/understanding-epigenetics-and-what-it-means-for-aging-cancer-and-obesity/

[10] https://www.whatisepigenetics.com/histone-modifications-and-epigenetic-regulation-could-hold-the-key-to-reversing-aging/

Simplesa® Announces the Launch of LunaCell™ – Most Advanced Form of Lunasin™

LunaCell™ is the next generation and most bioactive form of Lunasin available

CORAL SPRINGS, Fla., July 13, 2017 /PRNewswire/ — Simplesa® is launching LunaCell™, the next generation of Lunasin developed to have superior bioavailability.  LunaCell™ is the culmination of years of research, studies, patents, and technology that has been invested into making Lunasin more absorbable by the body.  Developed by the original Lunasin Research & Development Team, and now working with Simplesa®, LunaCell™ is produced using the most advanced extraction, processing, and standardizing techniques.  This makes LunaCell™ the most concentrated and efficient form of Lunasin ever produced. LunaCell delivers more bioavailable Lunasin than any other Lunasin supplement on the market today, all in a smaller and easier to swallow capsule.

LunaCell™ is the next generation and most bioactive form of Lunasin available
LunaCell™ is the next generation and most bioactive form of Lunasin available

Lunasin was originally developed as the first dietary compound with an identified epigenetic mechanism of action.  This mechanism (histone acetylation) was identified in 1996 and patented in 1999.  While many other dietary compounds are known to affect gene expression, their exact mechanisms of action (how they work) remain unknown.  The ground-breaking work identifying Lunasin’s epigenetic mechanism of action has been published in Nature Biotechnology and Cancer Research.  Epigenetics affect how genes are interpreted by our cells and subsequently react or reproduce new cells.1 Multiple studies have shown that Lunasin helps reduce oxidation of linoleic acid that produces oxygen radicals and acts as an oxygen radical scavenger (traditional antioxidant mechanism). It also reduces oxygen radicals produced by macrophages.

Free radicals are atoms or molecules that are highly reactive with other cellular structures because they contain unpaired electrons. As free radicals react with cellular structures, they lead to cellular injury and eventually cell death2. Free radicals may also trigger activation of various proteins that in turn activate an inflammatory response. Abnormally activated macrophages are highly specialized cells in our bodies that remove dying or dead cells and cellular debris, causing elevated levels of free radicals. LunaCell™ helps prevent and counteract cell damage and encourages healthy expression of cell growth and activity.

LunaCell™ is the effective and potent combination of Lunasin and protease inhibitors, which together deliver bioavailable Lunasin to the body.  In LunaCell, the Lunasin molecule is encased by protease inhibitors to form a protective shell which serves to prevent premature Lunasin destruction during digestion. As the molecule passes through the small intestine, the protease inhibitors break down to release bioavailable Lunasin for optimal absorption by the body. This is an important and distinctive factor of LunaCell™, as, without this protective coating, the Lunasin will break down too early during digestion, resulting in a loss of potency and maximum intake by the body.  It is the combination of Lunasin and the protease inhibitors in LunaCell™ that makes it the best choice for superior absorption by the body.

Simplesa® vice president Steve Margolis noted that “LunaCell™ is the most advanced Lunasin supplement available on the market today.  We saw LunaCell as an amazing and groundbreaking opportunity. We are always eager to advocate solutions that help people keep their supplemental and nutritional regimes simple.”

Beyond the improved bioavailability and absorption, the practical aspect of LunaCell™ is very important.  It offers more convenience and cost savings compared to other brands of Lunasin on the market. Since LunaCell has twice the potency of the Lunasin as other products, someone only needs to take half the number of capsules.  Moreover, the capsules are now smaller and therefore easier to swallow. LunaCell™ is practical, cost effective, and has easier dosing.

For more product information about LunaCell™ please visit: Simplesa.com/LunaCell

1 http://lunasin.com/lunasin-and-epigenetics

2 http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/?s=inflammation#free-radicals

Lyme Disease and ALS – Summer 2017

There is a lot of controversy regarding the connection between Lyme disease and ALS.

To understand the debate, let’s discuss some basics of both diseases as described by the experts.

lymediseaseimage

What is Lyme Disease:

Most people know that you get Lyme Disease from an infected tick, but many people don’t understand or realize the damage caused by Lyme Disease. If left untreated, the disease can lead to severe and life threatening medical issues.

“Lyme disease, the most common vector-borne illness in the United States, is a multi-system illness usually caused by infection with the spirochete Borrelia burgdorferi and the body’s immune response to the infection.[1] The disease is transmitted to humans via tick bites, from infected ticks of the genus Ixodes.”[1]

What is Amyotrophic Lateral Sclerosis (ALS)?

ALS is a progressive neurodegenerative disorder for which there is no cure.  Life expectancy following a diagnosis is two to five years.

“Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig’s disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) that are responsible for controlling voluntary muscles (muscle action we are able to control, such as those in the arms, legs, and face). This disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons.”[2]

How are these two diseases different?

ALS is currently an incurable disease. Lyme disease can be treated when discovered in a timely manner by antibiotics. If left untreated, Lyme disease can result in devastating medical problems and death. Lyme disease is known to mimic many of the symptoms of other diseases causing issues on diagnosis and subsequent treatment.

Because ALS and Lyme disease can exhibit similar symptoms, incidents of misdiagnosis of Lyme Disease as ALS have been reported.  This very recent case reported by NBC highlights a misdiagnosis of ALS when the patient actually had Lyme disease. The patient’s doctor insisted he had ALS, and they accepted the reality of this diagnosis.

“Matt remembered.”He said, “Enough’s enough. The reality is, you have ALS, and you know, you really need to embrace what I am telling you.” Matt’s family was told to help him come to terms with his death.

But inside their home, the Slatner family was doing their own research on Lyme symptoms and everything kept pointing to those tick bites.

“Every single thing is a Lyme symptom,” Stephanie said, remembering the long days and nights of research, three busy kids, and a husband who was slowly fading away. “No one would listen. I mean, they made us both feel like we were crazy.”[3]

Does everyone with ALS have Lyme?

“Lyme disease does not cause ALS, and generally in a diagnostic workup, a neurologist can easily separate ALS from Lyme infections, either clinically or with testing.”[4]

Despite the current belief that Lyme disease does not cause ALS, some studies have shown that many PALS do test positively for Lyme. This has caused a lot of disagreement between physicians and patients citing high statistical evidence of Lyme in many patients with ALS as more than just a coincidence.

Lyme Disease mimics other diseases

ALSLYME

( Image Ref: http://lymediseaseguide.org/wp-content/uploads/2011/07/lyme-disease-treatment-diagnosis.gif)

Does Lyme cause ALS? 

Many ALS patients have tested positively for Lyme disease, but not all Lyme patients develop ALS.  Currently, there is no definitive proof that Lyme disease causes ALS. Although often mistaken for ALS with similar symptoms, Lyme can be treated with antibiotics and other protocols dependent on the severity and progression. A cure for ALS still has not been found, but the Deanna Protocol has been shown to help with quality of life.

This topic continues to be a source of debate among physicians and PALS, with controversy evident on the internet and social media. If you are bitten by a tick, please seek medical attention immediately.

For more information on Lyme Disease: visit http://www.cdc.gov/lyme/

For more information on ALS: http://www.alsa.org/about-als/ 

[1] Ref: http://emedicine.medscape.com/article/330178-overview

[2] Ref: http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm

[3] http://m.nbc12.com/nbc12/db/345738/content/i7HSWfXF/gallery

[4] https://www.washingtonpost.com/opinions/five-myths-about-als/2014/08/22/70007ef2-2842-11e4-86ca-6f03cbd15c1a_story.html

Newest Update on Deanna Protocol

A recent article was released in March 2017, that examined an earlier study on the Deanna Protocol (DP).  The newest study concluded:

Targeting energy metabolism with the DP supplement as a metabolic therapy produces a change in the global metabolic profile of ALS mice that support the role of the DP for enhanced mitochondrial energy metabolism and prolongs time to paralysis of ALS C. elegans. (1)

For more information on the original article on please view the original article at:  https://link.springer.com/article/10.1007/s11306-017-1183-1

If you need information on how the Deanna Protocol can help you please contact us today for details and assistance.

Getting PALS the Help They Need FASTER!

ALS is an incurable disease at this time. When a patient and family is dealing with ALS, the last thing they should have to do is wait for financial and medical assistance. Currently, Social Security Disability Insurance (SSDI) has a typical 5-month waiting period for patients with ALS (PALS).

On Thursday, Feb. 16, Congressmen Seth Moulton (D-MA) and Peter King (R-NY) re-introduced The ALS Disability Insurance Access Act, bipartisan legislation they spearheaded to ensure that amyotrophic lateral sclerosis (ALS) patients are provided vital support and benefits in a timelier manner. The legislation would waive the Social Security Disability Insurance (SSDI) five-month waiting period for people living with ALS, commonly referred to as Lou Gehrig’s Disease.[1]

Many PALS are often diagnosed after they experience significant health deterioration and symptoms.  After dealing with the shock of this devastating diagnosis, PALS have to then apply for SSDI, which can be a lengthy and timely process. The ALS Association reports that fifty percent of all PALS succumb to their illness within 16 months of diagnosis.  The waiver of this 5-month waiting period to get sorely needed resources in an expedient and timely manner is critical.  “This legislation is especially important for people with ALS, for whom five months can mean the difference between life and death,” said Barbara Newhouse, President and CEO of The ALS Association.

The waiver implications go beyond just financial support. Medicare coverage is tied to the onset of the approval and start of SSDI.  The waiting period not only stalls much needed financial assistance to PALS and their families but also medical coverage for very costly care and potential medications.

We need your help to get this very important legislation quickly passed. You can send an e-mail to your members of Congress and personalize it with your story. Please urge your members of Congress to co-sponsor H.R. 1171/S. 379!  You can click here to send your support via the ALS Association website.

To track and monitor the status of this very important legislation you can visit the bill status on this website:   https://www.congress.gov/bill/115th-congress/house-bill/1171

Please see an excerpt of the bill here:

Bill History in the Congressional Record

Page numbers for legislative actions on this bill link to the Congressional Record. Learn more about the History of Bills and Resolutions.

From the Congressional Record, Volume 163 (2017)

——————————————————H.R. 1171–A bill to amend title II of the Social Security Act to     eliminate the five month waiting period for disability insurance     benefits for individuals with amyotrophic lateral sclerosis (ALS);     to the Committee on Ways and Means.  By Mr. MOULTON (for himself, Mr. King of New York, Mr. Bilirakis, Mr. Blumenauer, Mr. Cicilline, Ms. Clark of Massachusetts, Mr. Cohen, Mr. Conyers, Mr. DeFazio, Ms. DelBene, Mr. Engel, Mr. Garamendi, Mr. Heck, Mr. Jones, Mr. Keating, Mr. Kilmer, Ms. Michelle Lujan Grisham of New Mexico, Mr. MacArthur, Mr. McGovern, Mr. Peters, Ms. Pingree, Mr. Pocan, Miss Rice of New York, Mr. Richmond, Mr. Ruppersberger, Mr. Ryan of Ohio, Mr. Schiff, Mr. Sessions, Mr. Tonko, Mr. Walz, and Mr. Swalwell of California), H1300 [16FE]

If you need additional information on the bill or getting help read the original article form the ALS Association here:  http://www.alsa.org/news/media/press-releases/als-disability-insurance-access-act-021617.html

Please get involved today to CURE ALS and help PALS and their families improve their quality of lives.

[1] http://beverly.wickedlocal.com/news/20170220/moulton-king-continue-fight-for-als-patients

The Deanna Protocol® Continues to Impress ALS Patients

The Deanna Protocol is an all-natural metabolic program developed by Dr. Vincent Tedone which is continuing to improve the quality of life for people with ALS.

It was just a few years ago that the Ice Bucket Challenge caught everyone’s eye and raised awareness for ALS, or Lou Gehrig ’s disease.  At the time the Deanna Protocol® was relatively new but it was already helping many ALS patient’s lives.  According to a study by Winning the Fight, which researches “The Deanna Protocol,” a metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in an amyotrophic lateral sclerosis (ALS) mouse model.[1] The benefits of the Deanna Protocol to patients with ALS (PALS) is evident in the anecdotal feedback in recent years.

The Deanna Protocol® Metabolic Plan (also known as the DP™Plan) is a natural, drug-free, and inexpensive metabolic program developed for ALS. Scientific studies have proven that the DP™ Plan significantly slows the progression of ALS and extends life span. The DP™Plan is not an ALS treatment drug like Rilutek/Riluzole. It is a list of substances (AAKG, AKG, GABA, CoQ10, Niacin, and 5HTP) that are already found in the body. However, the amounts found in the body are not nearly enough for those who have ALS, so the DP™Plan provides the body and nerve cells with more of these substances to compensate for what they lack.  It is determined that the substances in the DP™ Plan provide energy to cells that are dying and in doing so keeps them alive.  This is very important because when nerve cells die, they release glutamate which kills the contiguous cells.[2]

In 2014 CBN News wrote that ‘Deanna Protocol’ Makes a Splash in ALS Research’. The study found “mice on The Deanna Protocol had improved neurological scores, increased motor function and most importantly, survived longer than the mice who weren’t on it.”[3]  Since this initial article, the Deanna Protocol has evolved in several major ways, in conjunction with assistance from Simplesa’s commitment to the ALS Community.  Simplesa® was founded in 2013 because it saw a need and had a solution.  ALS patients were having success following the Deanna Protocol, but it was too complex and expensive the way it was distributed. Simplesa® formulated products specifically for these ALS patients to simplify their regimen and lower the cost of the metabolic protocol.

Now all of the products needed to follow the protocol are offered in easy to follow combinations. Due to the improved ease of following the Deanna Protocol with the Simplesa products, the number of people following the protocol has increased. As the number of PALS following the Deanna Protocol has increased, Simplesa has also been able to reduce the cost of the protocol.  Additionally, to add further savings and flexibility to PALS, Simplesa® and Winning the Fight® teamed up to break the Deanna Protocol down into three bundled and more personalized options: Deanna Protocol Core, Plus, and Comprehensive Bundles.

The Deanna Protocol Core Bundle focuses on six essential nutrients of the Deanna Protocol. These nutrients primary support providing energy production to the body through the mitochondria of the cells.  The Plus Bundle builds on the Core Bundle by adding in Liposomal Glutathione, which helps the body push out toxins. It is considered the best antioxidant for the nervous system.  The Comprehensive Bundle builds on the Plus Bundle by adding in the AM & PM Blends. These blends come in two powders, one for the morning and one for the evening, and they contain an additional 20 amino acids that support muscle and nerve health. These combinations are based on the research publication by the NIH on nutrients that should be consumed by people who have ALS.

The affirmative feedback and reports from PALS to Simplesa® on the Deanna Protocol® have been very positive in the years since its inception.  PALS have continued to report improvement in quality of life:

“This product has worked wonders helping to reduce my pain, improve energy, lessen the severity muscle spasms, as well as improve balance and vertigo. I notice a day and night difference within taking my morning dose. I recommend taking the AKG throughout the day, not in lump 3 times a day to improve energy life.”

“My husband has been on the Deanna Protocol Products for two months now. He feels he has more energy and strength. We Would recommend these products!”

For more personal accounts on how the Deanna Protocol is helping PALS please click here.

The Deanna Protocol is not a cure for ALS, but it is a natural metabolic protocol that can help PALS improve their quality of life. To find out more about the Deanna Protocol® please contact Simplesa’s support team for information to see how it can help you or someone you know impacted by ALS.

References

*http://www.medicalnewstoday.com/articles/313919.php

[1] https://www.ncbi.nlm.nih.gov/pubmed/25061944
[2] https://www.winningthefight.org/deanna-protocolreg-metabolic-plan-for-als.html
[3] http://www1.cbn.com/cbnnews/healthscience/2014/August/Deanna-Protocol-Gains-Ground-in-ALS-Research

Simplesa Liposomal B12 the Powerhouse Energy Vitamin

Simplesa B12Even when you eat well and have a healthy diet you may still not be getting enough vitamin B12. When you are deficient there are symptoms, health risks, but you can easily address the deficiency with a quality B12 supplement.[1]

What is B12?
One form of Vitamin B12 is Methylcobalamin. It is one of the many B vitamins. Your body needs B12 to facilitate the healthy function of nerve tissue, brain function, and red blood cells.

Vitamin B12 is a powerhouse. Your metabolism wouldn’t run smoothly without it. But B12 isn’t like other vitamins. It’s only found in animal products like eggs, meat, shellfish and dairy. Up to 15% of people don’t get enough B12, and they’re more likely to be vegetarians, have celiac disease or other digestion problems, or be an adult over 50. The signs of vitamin B12 deficiency include exhaustion, rapid heartbeat, brain fog, and other symptoms, says Maggie Moon, RD, a Los Angeles–based nutritionist and owner of Everyday Healthy Eating.[2]

Like all B vitamins, vitamin B12 is a water-soluble vitamin. The human body does not store it. Any excess or unwanted amounts are excreted through urine. Structurally, vitamin B12 is the most complicated vitamin. It is also the largest.[3]

Why is Vitamin B12 so Important to our body?
Our bodies need vitamin B12 but do not make it and have to acquire it via proper nutrition and/or supplementation. Vitamin B12 is critical in the production of DNA, nerves, red blood cells, and to carry out other metabolic functions.  An average healthy adult requires approximately 2.4 micrograms a day, which can be an issue if you’re not consuming enough to meet your bodily needs. Some people may have an adequate intake of the appropriate nutrition, but malabsorption prevents them from utilizing it no matter how much they consume.

As a result, vitamin B12 deficiency is relatively common, especially among older people. The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency.[4]

Do I have a B12 deficiency?
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms it can cause; the condition can be overlooked or confused with something else. Symptoms may include:

·         strange sensations, numbness, or tingling in the hands, legs, or feet

·         difficulty walking (staggering, balance problems)

·         anemia

·         a swollen, inflamed tongue

·         yellowed skin (jaundice)

·         difficulty thinking and reasoning (cognitive difficulties), or memory loss

·         paranoia or hallucinations

·         weakness

·         fatigue

While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition. Early detection and treatment is important. “If left untreated, the deficiency can cause severe neurologic problems and blood diseases,” says Dr. Bruce Bistrian, chief of clinical nutrition at Harvard-affiliated Beth Israel Deaconess Medical Center.[5]

How can I avoid B12 Deficiency?
Simplesa® has just introduced its newest powerhouse supplement and high quality Liposomal Vitamin B12! Not all B12 vitamins are the same, Simplesa Liposomal Vitamin B12 boasts Methylcobalamin, the active form of vitamin B12 that supports brain and nerve health. With other forms of B12 your liver has to convert cyanocobalamin, another form of B12, into methylcobalamin.  Simplesa Liposomal Vitamin B12 is formulated for maximum and rapid absorption.

Simplesa Liposomal Vitamin B12 supports brain and nerve health with increased energy levels by providing methylcobalamin, the only form of vitamin B12 found in the brain.  Simplesa Liposomal Vitamin B12   does NOT contain soy ingredients, and the flavors are completely natural and delicious. The liposomes are gluten-free, alcohol-free, vegan, and tested non-GMO.

Simplesa Liposomal Vitamin B12 Benefit vs. Injectable B12
While injectable B12 is a commonly prescribed treatment for vitamin B12 deficiency, it does have some notable drawbacks. Because vitamin B12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician’s office for injection administration or affording the treatment if they don’t have insurance to cover it. [6] Additionally, the ease and cost savings is substantial via Simplesa Vitamin B12 as it can be easily self-administered at home and has a pleasant taste. One bottle will provide approximately 60 servings at ½ ml (approx. 3 pumps into the mouth) or 1000 mcg per serving.

Some of the many benefits of Simplesa Liposomal Vitamin B12:

·         Contributes to normal red blood cell formation

·         Supports the nervous system and mental functions

·         Contributes to a normal, healthy metabolism

·         Is essential for a healthy heart

Simplesa Liposomal Vitamin B12 uses natural non-hydrogenated sunflower phosphatidylcholine, derived from non-GMO certified oil.  It undergoes a several-step solvent-free purification and filtration process to ensure the utmost purity. The manufacturing facility is cGMP certified, following the same standards of sanitation and documentation as pharmaceutical companies. Each ingredient has been carefully sourced and tested in-house and by a third-party certified lab. The water is classified as Ultrapure Water, exceeding pharmaceutical grade standards.

For more information or to try our new Simplesa Liposomal Vitamin B12 click here.

[1] https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
[2] http://www.health.com/health/gallery/0,,20924065,00.html
[3] http://www.medicalnewstoday.com/articles/219822.php
[4]  http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[5] http://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780
[6] http://www.livestrong.com/article/289321-sublingual-vitamin-b12-vs-injectable-b12/

Holidays and Your Health

The holidays are frantic and stressful for everyone. If you are disabled or chronically ill, the holidays can present additional stress and potential health risks for you. For the caretaker of a chronically ill person the holiday can add another level of complexity and stress to your already busy life. No one wants to be a Grinch during this time of the year, but it is important to take some extra precautions and preparation to cope.

 

disabledchristmas

Per a recent article in the Huffington Post called “5 Ways the Holidays Are Hard on Those with a Chronic Disease (and 10 Ways to Cope)” the author provides advice on how to deal with the barrage of food, activity and traveling that may occur.

Food: Food is at the heart of nearly all holiday celebrations, and usually steaming mounds of not-so-healthy foods like sugary sweet potatoes. Desserts and sweet drinks are in abundance. For a person with a chronic disease, the variety of foods may be tempting or forbidden, or may just strike terror in our hearts or feelings of being bothered. If you’re staying in a hotel, you might be relegated to eating the in-house free breakfast that doesn’t accommodate your diet.

Traveling: Sitting in a car or on a plane for long periods of time can be the breeding ground for physical pain or, at minimum, provide ample time to worry about one’s disease. Traveling also means a change of routine and a lot of unpredictability and extra stress. For example, flying means I have to go through security at the airport, go through a pat-down while the rest of my family stands by waiting, and explain to multiple personnel what my disease is, what my devices do, and no, they cannot be removed from my body for inspection. Time zone and altitude changes can also be difficult.

Activity: Some holiday celebrations include activities which might be out of your typical routine: skiing, going from house-to-house visiting relatives, power-shopping with your mom on Black Friday. These activities can cause your disease to flare-up in undesirable ways, zapping your energy and bringing down your mood. [1]

For the caregiver who is constantly on call, the holidays just might seem like too much. If you know a caregiver the best thing to do this time of year is help. Perhaps offer to cook, shop, or just spend time with them. Many caregivers get burned out and need a break. Some suggestions for caregivers on how to avoid burnout this time of year are found in a great article by Empowher.com called “3 Steps to Avoiding Caregiver Burnout during the Holidays.”[2] The three biggest things to remember is know the signs of when you need a break, take care of yourself, and remember to ask for help. This is often easier said than done for many caregivers. Resources for help can be found at “The National Family Caregiver Association offers many tips and guides on how to take charge and effectively communicate with caregivers.  Log on to www.thefamilycaregiver.org or call them at 800-896-3650.”[3] The following great tips were found on Everydayhealth.com[4]:

*Eat healthy and try to exercise every day.

*Indulge in an enjoyable activity as often as you can – read a book, work on a hobby, or watch a movie.

*Pamper yourself with a massage or manicure.

*Keep a journal to record your thoughts and feelings.  This can be a good outlet for
frustrations.

* Be in touch with your own body and know when you are becoming ill or run down;
seek medical advice in a timely manner.

*If applicable seek support from your church or synagogue. Besides spiritual support, they often have programs to help caregivers.

*Remember that “laughter is the best medicine.”  Try to find some humor in daily situations.

*Join a support group.  If you can’t leave the house explore Internet options.

If you know a caregiver or chronically ill person, please remember that one of the best things you can offer this holiday season is love, support, time and help.

 

[1] http://www.huffingtonpost.com/rachel-garlinghouse/5-ways-the-holidays-are-hard-on-those-with-a-chronic-disease-and-10-ways-to-cope_b_8435494.html

[2] http://www.empowher.com/caregiving/content/3-steps-avoiding-caregiver-burnout-during-holidays

[3] http://www.everydayhealth.com/columns/lynda-shrager-the-organized-caregiver/how-to-avoid-caregiver-burnout-this-holiday-season/

[4] http://www.everydayhealth.com/columns/lynda-shrager-the-organized-caregiver/how-to-avoid-caregiver-burnout-this-holiday-season/

Metabolics and ALS

We often hear that we are what we eat.  Most people know how important it is to eat balanced healthy foods to stay healthy, but the importance of diet and nutrients is increased when you are ill. Often the symptoms or side effects of the disease are impaired metabolic function. Even eating a healthy diet won’t completely rectify this concern. Chronically ill patients sometimes can’t obtain the nutrients they require and/or the metabolizing process of nutrients has broken down. This breakdown impacts other critically important bodily functions.

Basics of Nutrition and Metabolism

Figure 1 – https://prezi.com/j5mbaoirevn1/copy-of-nutrition-vs-metabolism/#

In the recent article from National Institute of Health in November 2016 researchers found in the study “Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis”:

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers. Metabolomics is a postgenomics field that offers fresh insights for biomarkers of common complex as well as rare diseases. Using data on metabolite-disease associations published in the previous decade (2006-2016) in PubMed, ScienceDirect, Scopus, and Web of Science, we identified 101 metabolites as putative biomarkers for these three neurodegenerative diseases. Notably, uric acid, choline, creatine, L-glutamine, alanine, creatinine, and N-acetyl-L-aspartate were the shared metabolite signatures among the three diseases. The disease-metabolite-pathway associations pointed out the importance of membrane transport (through ATP binding cassette transporters), particularly of arginine and proline amino acids in all three neurodegenerative diseases. When disease-specific and common metabolic pathways were queried by using the pathway enrichment analyses, we found that alanine, aspartate, glutamate, and purine metabolism might act as alternative pathways to overcome inadequate glucose supply and energy crisis in neurodegeneration. These observations underscore the importance of metabolite-based biomarker research in deciphering the elusive pathophysiology of neurodegenerative diseases. Future research investments in metabolomics of complex diseases might provide new insights on AD, PD, and ALS that continue to place a significant burden on global health.[1]

A year earlier, another study published in JAMA, October 2015, “Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis” concluded:

 that Antioxidants, carotenes, fruits, and vegetables were associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis. We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes.[2]

Nutrition is especially important for ALS patients, and following the Deanna Protocol™ “supercharges” the right nutrition for patients with ALS (PALS). It also aids as a metabolic therapy and supports energy metabolism. A study published in 2014 by the National Institute of Health investigated and found that the Deanna Protocol® (DP):

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. There is currently no cure or effective treatment for ALS. Besides motor neuron degeneration, ALS is associated with impaired energy metabolism, which is pathophysiologically linked to mitochondrial dysfunction and glutamate excitotoxicity. The Deanna Protocol (DP) is a metabolic therapy that has been reported to alleviate symptoms in patients with ALS. In this study we hypothesized that alternative fuels in the form of TCA cycle intermediates, specifically arginine-alpha-ketoglutarate (AAKG), the main ingredient of the DP, and the ketogenic diet (KD), would increase motor function and survival in a mouse model of ALS (SOD1-G93A). ALS mice were fed standard rodent diet (SD), KD, or either diets containing a metabolic therapy of the primary ingredients of the DP consisting of AAKG, gamma-aminobutyric acid, Coenzyme Q10, and medium chain triglyceride high in caprylic triglyceride. Assessment of ALS-like pathology was performed using a pre-defined criteria for neurological score, accelerated rotarod test, paw grip endurance test, and grip strength test. Blood glucose, blood beta-hydroxybutyrate, and body weight were also monitored. SD+DP-fed mice exhibited improved neurological score from age 116 to 136 days compared to control mice. KD-fed mice exhibited better motor performance on all motor function tests at 15 and 16 weeks of age compared to controls. SD+DP and KD+DP therapies significantly extended survival time of SOD1-G93A mice by 7.5% (p = 0.001) and 4.2% (p = 0.006), respectively. Sixty-three percent of mice in the KD+DP and 72.7% of the SD+DP group lived past 125 days, while only 9% of the control animals survived past that point. Targeting energy metabolism with metabolic therapy produces a therapeutic effect in ALS mice which may prolong survival and quality of life in ALS patients.[3]

One thing shown over and over via these studies and anecdotal reports from PALS is that the Deanna Protocol® Metabolic Therapy is helping many PALS with quality of Life.

New studies are underway. the scientists at University of South Florida (USF) are moving forward with the experiment to determine the efficacy of the Deanna Protocol® Plan when combined with glutamic oxaloacetate transaminase (GOT). [4]

The DP® Plan focuses on cell metabolism. It delivers Alpha-ketoglutarate (AKG) to the Krebs Cycle in the neurons. The increase in AKG enables their mitochondria to produce enough energy to keep cells alive, despite their exposure to an unhealthy amount of extracellular glutamate.  AKG usually does not pass through the cell membranes in normal healthy cells.  Based on our experience, we found that the permeability of the cell membrane in diseased or damaged cells changes and allows AKG to permeate the cells. Due to the fact that AKG only enters diseased cells, the substance only goes where it is needed.

If you need more information on how Simplesa® Deanna Metabolic Plan can help you, please contact us for assistance.

Footnotes:

[1] https://www.ncbi.nlm.nih.gov/pubmed/27828769

[2] http://jamanetwork.com/journals/jamaneurology/fullarticle/2570546

[3] https://www.ncbi.nlm.nih.gov/pubmed/25061944

[4] https://www.winningthefight.org/latest-developments

Caregivers – “Take Care to Give Care”

 caregivingCaregiving – It’s one of the hardest, physically and emotionally draining roles anyone can undertake.  In a 2015 survey from AARP and the National Alliance of Caregiving it was found that a third of all Americans are caregivers, providing care to someone who is disabled, ill or elderly.  The same study found that almost 80% of these caregivers stated they needed help.[1] Caregivers can be family members or friends. Many caregivers have jobs, families, and the additional responsibility of the minute to minute needs of the person to whom they are providing care 24/7.  It is not just driving to doctor visits or making meals. Many caregivers are providing nursing care (maintaining Stomas, catheters, or feeding tubes), often without the training or previous experience to do so. Caregivers learn quickly as the lives and well-being of someone they love relies on them. Perhaps the person being cared for is not a good patient, or does not remember you, or has tremendous guilt in being ill or helpless. These are all potential circumstances that many caregivers have to face every day. It’s one of the experiences in life that unless you have done it – you won’t quite understand the demands or the challenges.

Tips for Caregiver:

The first rule of taking care of others: take care of yourself first. Caregiving can be a rewarding experience, but it is also physically and emotionally demanding. The stress of dealing with caregiving responsibilities leads to a higher risk of health issues among the nation’s 90 million family caregivers. So as a family caregiver, remember to pay attention to your own physical and mental wellness, and get proper rest and nutrition. Only by taking care of yourself can you be strong enough to take care of your loved one. You really do need to “take care to give care!”

  • Caregiving can be a stressful job. Most family caregivers say they feel stressed providing care for a loved one. With all of their caregiving responsibilities – from managing medications to arranging doctor appointments to planning meals – caregivers too often put themselves last.
  • The stress of caregiving impacts your own health. One out of five caregivers admit they have sacrificed their own physical health while caring for a loved one. Due to stress, caregivers have a disproportionate number of health and emotional problems. They are twice as likely to suffer depression and are at increased risk for many other chronic conditions.
  • Proper nutrition helps promote good health. Ensuring that you are getting proper nutrition is key to help maintain your strength, energy and stamina, as well as strengthening your immune system. Maintaining a healthy diet is one of the most powerful things you can do to take care of yourself and keep a positive attitude overall.
  • Ensuring good nutrition for your loved one helps make care easier. As many as half of all older adults are at risk for malnutrition. Good nutrition can help maintain muscle health, support recovery, and reduce risk for re-hospitalization – which may help make your care of a loved one easier.
  • Remember: “Rest. Recharge. Respite.” People think of respite as a luxury, but considering caregivers’ higher risk for health issues from chronic stress, those risks can be a lot costlier than some time away to recharge. The chance to take a breather, the opportunity to re-energize, is vital in order for you to be as good a caregiver tomorrow as you were today.[2]

What is Respite?

According to the Lifespan Respite Care Act (PL 109-442), Lifespan Respite is defined as ‘coordinated systems of community-based respite for family caregivers of children or adults regardless of special need.’  For more information, on Respite please visit: https://archrespite.org/index.php

Tips for Others:

As a caregiver your world at times feels like it’s in chaos and out of your control.  Interacting with other people can often be tiresome and difficult as you simply feel too overwhelmed to participate in social settings. Other people often want to help and support you, but struggle with what they can say and do to help.  We have compiled some great suggestions for what to say or not to say to caregivers.  Please feel free to send suggestions we have not mentioned in this blog. Interesting enough, there is some overlap on the advice on what best to say or not to say to caregivers. Bottom line:  speak from the heart and be supportive of their needs.

12 Things You Should Say to a Family Caregiver By Becky Benishek

Keep in mind many caregivers won’t ask for help, so the best way to help someone is to do things for them that they may not have the time, money, or mental energy to do for themselves. Social settings and activities may at times be too draining, or the fear of being a “bummer” or not in “the best mood” can often cause many caregivers to go into recluse mode.

A Dozen Things You Should Never Say to A Caregiver by Ann Brenoff

There is assistance and resources to help caregivers.  Many times a caregiver is so consumed in the day to day tasks of caregiving they don’t have the bandwidth to research tools or support.  One such resource is geared to caregivers of Veterans.  Per the Veteran Benefits: Caregiver Programs and Services on Military.com website:

On May 5, 2010, the Caregivers and Veterans Omnibus Health Services Act of 2010 was signed into law. Title I of the Act will allow VA to provide unprecedented benefits to eligible Caregivers (a parent, spouse, child, step-family member, extended family member, or an individual who lives with the Veteran, but is not a family member) who support the Veterans who have given so much for this Nation. The law distinguishes between Veterans who incurred or aggravated a serious injury in the line of duty on or after Sept. 11, 2001 (post-9/11 Veterans), and those Veterans whose injuries were incurred prior to Sept. 11, 2001 (pre-9/11 Veterans).

Please visit the VA’s caregiver page for more information, and to apply for these services.

 Caregivers Toolbox:

http://caregiveraction.org/family-caregiver-toolbox

http://www.caregiving.org/resources/

http://www.rosalynncarter.org/caregiver_resources/

https://www.medicare.gov/campaigns/caregiver/caregiver.html

http://www.aarp.org/home-family/caregiving/?cmp=RDRCT-CRGNG_APR12_012

http://www.easterseals.com/explore-resources/for-caregivers/understanding-aging-and-caregiving.html

Footnotes:

[1] http://www.huffingtonpost.com/entry/a-dozen-things-you-should-never-say-to-a-caregiver_us_5621409fe4b08589ef474317

[2] http://caregiveraction.org/national-family-caregivers-month-theme/

Flu Season & Keeping Healthy

The Flu season impacts a lot of people this time of year. There is always a lot of media about getting sick, so we have compiled some useful resources that could come in handy to stay healthy.

When is Flu Season?

The Flu season runs from October into late spring. The CDC says “the flu season begins when certain key flu indicators (for example, levels of influenza-like illness (ILI), hospitalization and deaths) rise and remain elevated for a number of consecutive weeks. Usually ILI increases first, followed by an increase in hospitalizations, which is then followed by increases in flu-associated deaths.” ¹

What is the difference between a Cold and the Flu?
Both a cold and Flu are respiratory illnesses. Typically, a cold is far less severe in nature and duration. Most of us know all too well that a bad cold and related symptoms will usually last for a few days or a week. Lingering symptoms that persist or worsen can indicate you have the Flu or a secondary concern.  Flu symptoms can make you ill for days to even weeks.

Why is the Flu a big deal?
No one likes to get sick, and getting a nasty cold during cold weather seems bad enough. A Flu can often be far worse in symptoms, downtime, and complications than a typical cold.
For those with chronic illness or disabilities it can be an incredibly dangerous. A recent article and video from CNN tells many “It’s time to get your flu shot.” Those who are young, old, or at risk from the complications that might occur from the Flu on a weaker immune system need to be protected.

Fight the Flu
Fight the Flu

How to protect yourself from the Flu?
One suggested precaution is to get the Flu vaccination / shot. The Flu vaccination this year is “expected to be more effective than last season.” ² It is recommended that not only should high risk people get the shot, but also those who spend time around them. Caretakers and family members also have be cautious as they can be contagious and transmit the Flu.

Why do I need a Flu shot every year?
Many wonder why we need to get another Flu vaccination every year. The reason is simple: the virus changes. A recent article in USA Today states that doctors are anticipating this to be a tough season and a nasty Flu. “Dr. Robin Altman, chief of general pediatrics for Children’s & Women’s Physicians of Westchester, suspects this may be another tough battle with the virus. Altman is urging patients to get vaccinated now, since it takes two weeks for the body to build up immunity. The flu vaccine remains the best protection against the virus.”³

I have ALS should I get the Flu Shot?
Protecting those with ALS from the Flu is very important. The ALS Association wrote a recent article about what you need to know to protect people with ALS from the Flu. Avoiding crowded places or people who are sick with either a cold or Flu is recommended. Some common sense and good hygiene are suggested. Caretakers and family members of those with ALS may want to get vaccinated.  ALS patients should always discuss the benefits and risks of getting vaccinated with their doctor. 4

A Flu for a person with weak swallowing and respiratory processes represents a significant health issue. Additional information on the Flu Virus and protecting your family and yourself this Flu season can also be found on: http://www.earlydetectionplan.org/

SOURCES

[1] http://www.cdc.gov/flu/about/season/flu-season-2015-2016.htm

[2] http://www.cnn.com/2015/10/07/health/flu-shot-vaccine-2015/

[3] http://www.usatoday.com/story/news/nation-now/2015/10/05/flu-season-underway/73383394/

[4] http://www.alsa.org/news/vision-express/articles/october-2015/flu-season.html

Managing Quality of Life for ALS Patients

Winning the Fight is a mostly volunteer 501(c)3 non-profit organization that develops and studies nutritional therapies for ALS (Amyotrophic Lateral Sclerosis). They developed a metabolic program for ALS called the Deanna Protocol®  and scientific studies show that the program is indeed effective! Winning the Fight posted a very interesting article on their site and we wanted to share it with you.

Management Versus Cure
Scientists have been seeking a cure for ALS for over 130 years and none has been found. While scientists look for a cure for future ALS patients, thousands of patients currently suffering from ALS die as they wait for that cure to come. The life expectancy for those with ALS is so short that those living with the disease today most likely will not be alive to witness the discovery of a cure. Even if they would be alive when a cure is discovered, the chance of them remaining alive to see that cure gain FDA approval and become readily available to the public is slim.

As you can see, any cure that is found will benefit those diagnosed in the future, not those who have ALS now and are facing a life expectancy of two to five years. Who in the medical community is focusing them? Who is trying to keep them alive and well long enough for a cure to be found?

Winning the Fight, Inc. is the only organization that has bee focusing its research on prolonging the lives of those who have ALS now, improving their quality of life, and maintaining their physical function until a cure is found. This cause is just as worthy as the mission to find a cure, yet Winning the Fight’s research only received .009% of the total funding from last year’s Ice Bucket Challenge. (We received $10,000 and ALS Association received $110,000,000.) Those who are suffering and dying now deserve more than .009% of the nation’s financial commitment to ALS during this year’s ice bucket challenge. Wouldn’t you agree?

If you’d like to donate to organizations looking for a cure, great! You should. Please consider splitting your funds between Winning the Fight and those organizations. There are ALS patients who need you now. Please, give them more than .009%.

You Can Help Improve the Deanna Protocol® by Purchasing from Simplesa!

Simplesa will donate a portion of the proceeds of all sales of Deanna Protocol® products to Winning the Fight and Winning the Fight will use these donations to fund research to optimise the Deanna Protocol®.

About Winning the Fight, Inc. (WFND) 

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Getting Fishy with Omega-3s

For a long time, there has been a lot of debate over healthy and unhealthy fats. But it “was the Omega-3 fats that made fish famous.”[1]  Fatty Acids are required by our body. Our body does not make Omega -3 and it can only be obtained by certain foods or supplements.

The human body can make most of the types of fats it needs from other fats or raw materials. That isn’t the case for omega-3 fatty acids (also called omega-3 fats and n-3 fats). These are essential fats—the body can’t make them from scratch but must get them from food. Foods high in Omega-3 include fish, vegetable oils, nuts (especially walnuts), flax seeds, flaxseed oil, and leafy vegetables.[2]

Source http://newhope.com/news-analysis/share-educational-omega-3-infographic
Source http://newhope.com/news-analysis/share-educational-omega-3-infographic

Many people, either through poor dietary habits or health concerns, cannot eat the required foods to obtain these critical fats.  But remember, not all fats are created equal. Omega-3 fats have been revealed to assist with many of the essential processes of the body and deter health concerns.

Omega-3 fats provide the starting point for making hormones that regulate blood clotting, contraction and relaxation of artery walls, and inflammation. They also bind to receptors in cells that regulate genetic function. Likely due to these effects, omega-3 fats have been shown to help prevent heart disease and stroke, may help control lupus, eczema, and rheumatoid arthritis, and may play protective roles in cancer and other conditions.[3]

Simplesa® has just introduced its newest product, Omega 3 EFA (Essential Fatty Acids) which contains 1500 mg of Omega-3 Fatty Acids, 800 mg of EPA (Eicosapentaenoic Acid), 600 mg of DHA (Docosohexanoic Acid) and 100 mg of other Omega-3 Fatty Acids per two soft gel serving.   It contains the three main Omega-3 fats in the family of polyunsaturated fats.  The blend contains Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and other Omega-3 acids.  Simplesa has created a trifecta for one of the highest quality fish oil products on the market. The lemon flavored enteric coated soft gel allows for maximum absorption without the “fish burps” of some other Omega 3 supplements. It is perfect for those who are sensitive to the smell of the fish oil tablets. This super concentrated Omega-3 fish oil is an excellent source of Omega-3 fatty acids.

  • High quality lemon flavor fish oil for those who are sensitive to the taste of the fish oil tablets.
  • Multi-stage molecular distillation process that both concentrates the Omega 3 EPA and DHA and removes environmental toxins.
  • Concentrated Omega-3 provides an excellent source of Omega-3 fatty acids.

The timing of the launch of this new product aligns with a recent JAMA study published on Time.com that was released in June 2016.  This study supports the health benefits of Omega-3s.

Recently, a large study led by researchers at Tufts University and published in JAMA Internal Medicine added to the weight of evidence in favor of the fatty acids for heart health. The researchers looked at levels of omega-3s in the blood and tissue of 45,637 healthy people, using data from 19 prospective and retrospective studies, to see if there was a connection to coronary heart disease. They didn’t find a link between omega-3s and heart attacks in general, but they did find that people who had diets rich in fish-derived omega-3s had a lower risk of fatal heart attacks. How impressive the association depended on their omega-3 consumption. For every extra serving or so of fish a week, they saw about a 10% reduction in risk, and people who ate the most fish had about a 24% lower risk of fatal heart attack than people who ate the least.  “Evidence from experimental models and animal studies show that a major effect of these omega-3 fatty acids is to stabilize heart membranes,” says Liana Del Gobbo, lead author of the study who is now a research fellow at Stanford University. Stable heart membranes means the heart is less likely to go into life-threatening dangerous rhythms, adds O’Keefe (who was not involved with the study).[4]

Although consumption of important nutrients via diet is always ideal, not everyone can consistently consume the quantities recommended to benefit health. Also, some people just don’t like to eat fish, so finding a quality effective “non” fishy supplement is very important.  For more information on Simplesa® Omega 3 please click here.

.[1] http://time.com/4396909/omega-3s-heart-health-fish-oil/?xid=newsletter-brief

[2] https://www.hsph.harvard.edu/nutritionsource/omega-3-fats/

[3] https://www.hsph.harvard.edu/nutritionsource/omega-3-fats/

[4] http://time.com/4396909/omega-3s-heart-health-fish-oil/?xid=newsletter-brief

Sleep Well and Feel Better – Sleep Complex

When did getting enough sleep become such a challenge and complex?  For many people, sleeping well is a frustrating and debilitating part of their life.  What do you do to help you fall and stay asleep?

Everyone needs differing amounts of sleep to feel rested and maintain their physical and mental well-being. Without the appropriate length and quality of sleep, a person can suffer in how they think, react, and feel.  Everyone needs “healthy” sleep.  Lack of sleep has been shown to be a factor in “cardiovascular health, obesity, diabetes, and psychological wellbeing.”[1]  Lack of sleep is not only an issue for adults but recent studies have found too little sleep can be an issue in children as well.  Generally, if our kids are not sleeping neither are the parents.  In a recent article on Reuters Health, the dangers of children and teens getting too little sleep are discussed, and it notes new recommendations by the American Academy of Sleep Medicine (AASM) guidelines.

“At least 25 percent of 12-year-olds get less than the recommended nine hours of sleep per night and there is increasing evidence that this impacts learning and memory,” said Dr. Stuart F. Quan of Brigham and Women’s Hospital, Boston, a coauthor of the new American Academy of Sleep Medicine (AASM) guidelines.[2]

During different parts of your life, you need to sleep to grow, recover from illness, and also maintain the equilibrium of your body’s natural resources.  For those with chronic pain from injury or who have a chronic illness, adequate sleep can actually improve the degree of pain.  Understandably, that proves to be a catch 22 as many with chronic pain just cannot sleep.  Many times, not sleeping is also an indicator of a bigger health issue.  If you have always slept well, then suddenly are experiencing problems, looking at your overall health and stress level is important to determine the cause and find a solution.

There is abundant scientific data and links between the lack of sleep as a factor or sign of serious health problems.  Sleep deprivation impacts your mind and body on every level. When you are over-tired you’re more likely to get injured, pay less attention to details or safety, your memory is impaired, become more easily angered, and are at a heightened risk to injury and/or accident.  You may become unable to focus, very irritable, and or in some severe cases become irrational.

Studies have also shown a direct correlation to sleep deprivation and weight control.  This makes sense, as being very tired will discourage you from regular exercise or you may eat unhealthy foods for a quick boost of energy or comfort.

The other part is physiological. The hormone leptin plays a key role in making you feel full. When you don’t get enough sleep, leptin levels drop. Result: people who are tired are just plain hungrier — and they seem to crave high-fat and high-calorie foods specifically.[3]Your Immunity seems impacted by lack of sleep.

There are a lot of myths that suggest what you can or cannot do to fall and stay asleep.  Some suggestions to getting more sleep:

  1. Regular Exercise – but not too close to bedtime.
  2. Don’t use television for “white noise” – try relaxing timed music instead.
  3. Avoid prescribed or narcotic sleep aids as they can often can become addictive, and can relieve insomnia but don’t cure it.
  4. Try natural supplements that are healthy and non-addictive.

Sleep ComplexSimplesa® has a new product that combines all the best herbal and natural ingredients to aid in a healthy and natural sleep.  Sleep Complex is a unique dietary sleep supplement with multi-nutrient & herb complex. Simplesa Sleep Complex combines the natural, powerful combination of B-6 (pyridoxine hydrochloride), Magnesium (gluconate), Melatonin, Valerian Root Powder, Hops Flower Powder, Passion Flower Powder, and Chamomile Flower Powder. This propriety blend leverages traditional herbalism in a propriety formula. It is recommended to take one to two capsules per evening of the natural sleep supplement, and it will soothe your mind and encourage a natural sleep cycle.  Highlights of this natural sleep aid are:

  • High Absorption Melatonin promotes the body’s natural sleep cycle in a non-addictive sleep aid.
  • Herbal sleep supplement triggers important natural sleep transmitters within the body and helps to balance hormonal function and the musculoskeletal system.
  • Proprietary Herbal Sleep Formula eases and calms your body into a natural sleep cycle for a restful night.

These various natural ingredients are known to help sleep:

Calcium is a natural sleep aid that can help you fall asleep and have a restful sleep. The mineral contains tryptophan, an amino acid the body uses to produce melatonin, a natural hormone that helps induce and maintain sleep, the National Sleep Foundation reports. Research shows low calcium levels are associated with disturbed sleep patterns, including the lack of a deep REM sleep phase, according to Medical News Today. When levels of calcium are inadequate, you may wake up soon after falling asleep and have trouble getting back to sleep.[4]

Magnesium is well known for its ability to relieve insomnia. One study found that it helps decrease cortisol, the “stress hormone” that can keep you up at night. It also helps muscles relax, to give you that calm “sleepy” feeling and help you unwind after a long day. On top of helping you get a good night of sleep, it also shows potential as a therapy for depression and other mood disorders.[5]

Melatonin – Your body [naturally] makes melatonin, which helps create the urge to fall asleep,” says Sanjeev Kothare, M.D., director of the pediatric sleep program at NYU Langone Medical Center. “We call it ‘the hormone of the dark’ because it starts rising as it gets late and the light intensity [of the day] goes down.” Melatonin is key in regulating your body’s internal clock, also known as your circadian rhythm, says Andrew Westwood, M.D., a board-certified sleep physician and assistant professor at Columbia University.[6]

Getting a good night sleep just got easier with Simplesa Sleep Complex!  For more information on Sleep Complex please click here.

[1] http://www.sleephealthresearch.com/shrp/index.html

[2] http://www.reuters.com/article/us-health-kids-sleep-idUSKCN0YZ2DN

[3] http://www.webmd.com/sleep-disorders/features/9-reasons-to-sleep-more?page=2

[4] http://www.livestrong.com/article/547625-benefits-of-calcium-before-bed/

[5] http://paleoleap.com/magnesium/

[6] http://dailyburn.com/life/lifestyle/sleep-what-is-melatonin/